Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury
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Junwei Yang | C. Dai | Weichun He | A. Zhao | Yuan Gui | Qingmiao Lu | Xiaoli Sun | Yan Liang | M. Gu | Xian Xue | Bo Xiao | Mingjie Wang | Xingwen Zhu | Mengru Gu
[1] Xiaohui Li,et al. Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function , 2018, Nature Communications.
[2] H. Castrop,et al. Renal Interstitial Platelet-Derived Growth Factor Receptor-β Cells Support Proximal Tubular Regeneration. , 2018, Journal of the American Society of Nephrology : JASN.
[3] Youhua Liu,et al. Fibroblast-Specific β-Catenin Signaling Dictates the Outcome of AKI. , 2018, Journal of the American Society of Nephrology : JASN.
[4] L. Lau,et al. Resolution of organ fibrosis , 2018, Journal of Clinical Investigation.
[5] R. Kramann,et al. Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury. , 2017, Journal of the American Society of Nephrology : JASN.
[6] K. Yokote,et al. Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells , 2016, Nature Communications.
[7] Raymond Vanholder,et al. International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology , 2015, The Lancet.
[8] Lei Jiang,et al. Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis , 2015, Kidney international.
[9] Weizhen Zhang,et al. Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway , 2014, Proceedings of the National Academy of Sciences.
[10] Lei Jiang,et al. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. , 2014, Kidney international.
[11] M. Boerries,et al. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress , 2014, Proceedings of the National Academy of Sciences.
[12] Dudley Lamming,et al. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2) , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[13] S. Gygi,et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis , 2013, Nature Cell Biology.
[14] L. Platanias,et al. The evolution of the TOR pathway and its role in cancer , 2013, Oncogene.
[15] W. Liu,et al. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis. , 2013, Journal of the American Society of Nephrology : JASN.
[16] Youhua Liu,et al. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury , 2013, Kidney international.
[17] P. Rabinovitch,et al. mTOR is a key modulator of ageing and age-related disease , 2013, Nature.
[18] P. Igarashi,et al. Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice , 2012, Kidney international.
[19] J. Bonventre,et al. Cellular pathophysiology of ischemic acute kidney injury. , 2011, The Journal of clinical investigation.
[20] J. Bonventre,et al. Repair of injured proximal tubule does not involve specialized progenitors , 2011, Proceedings of the National Academy of Sciences.
[21] B. Molitoris,et al. Pathophysiology of ischemic acute kidney injury , 2011, Nature Reviews Nephrology.
[22] P. Worley,et al. Rheb1 is required for mTORC1 and myelination in postnatal brain development. , 2011, Developmental cell.
[23] B. Kennedy,et al. The TOR pathway comes of age. , 2009, Biochimica et biophysica acta.
[24] D. Sabatini,et al. DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival , 2009, Cell.
[25] A. Cohen,et al. Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. , 2009, Stem cells and development.
[26] M. Le Hir,et al. The renal cortical interstitium: morphological and functional aspects , 2008, Histochemistry and Cell Biology.
[27] A. McMahon,et al. Intrinsic epithelial cells repair the kidney after injury. , 2008, Cell stem cell.
[28] G. Remuzzi,et al. Insulin-like growth factor-1 sustains stem cell mediated renal repair. , 2007, Journal of the American Society of Nephrology : JASN.
[29] N. Lloberas,et al. HGF gene therapy attenuates renal allograft scarring by preventing the profibrotic inflammatory-induced mechanisms. , 2006, Kidney international.
[30] P. Devarajan. Update on mechanisms of ischemic acute kidney injury. , 2006, Journal of the American Society of Nephrology : JASN.
[31] Kebin Hu,et al. Hepatocyte Growth Factor Is a Downstream Effector that Mediates the Antifibrotic Action of Peroxisome Proliferator–Activated Receptor-γ Agonists , 2005 .
[32] A. Hishida,et al. Transient myofibroblast differentiation of interstitial fibroblastic cells relevant to tubular dilatation in uranyl acetate-induced acute renal failure in rats , 2005, Virchows Archiv.
[33] Jie Chen,et al. regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. , 2004, Diabetes.
[34] A. Joyner,et al. Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning , 2004, Cell.
[35] D. Guertin,et al. Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton , 2004, Current Biology.
[36] Youhua Liu. Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. , 2004, American journal of physiology. Renal physiology.
[37] J. Blenis,et al. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb , 2003, Current Biology.
[38] B. Edgar,et al. Rheb promotes cell growth as a component of the insulin/TOR signalling network , 2003, Nature Cell Biology.
[39] J. Bonventre. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. , 2003, Journal of the American Society of Nephrology : JASN.
[40] K. Inoki,et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling , 2002, Nature Cell Biology.
[41] Junwei Yang,et al. Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice. , 2002, Journal of the American Society of Nephrology : JASN.
[42] Youhua Liu. Hepatocyte growth factor and the kidney , 2002, Current opinion in nephrology and hypertension.
[43] K. Matsumoto,et al. Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases. , 2001, Kidney international.
[44] A. Hishida,et al. Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats. , 2000, The American journal of pathology.
[45] A. Hoeflich,et al. Hepatocyte growth factor in renal failure: promise and reality. , 2000, Kidney international.
[46] W. Lieberthal,et al. Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury. , 1996, The American journal of physiology.
[47] C. Barnes,et al. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. , 1994, The Journal of biological chemistry.
[48] H. Takahashi-Iwanaga. The three-dimensional cytoarchitecture of the interstitial tissue in the rat kidney , 1991, Cell and Tissue Research.
[49] J. Bonventre,et al. Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. , 2011, Contributions to nephrology.
[50] Junwei Yang,et al. Role of Bcl-xL induction in HGF-mediated renal epithelial cell survival after oxidant stress. , 2008, International journal of clinical and experimental pathology.
[51] Kebin Hu,et al. hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists. , 2006, Journal of the American Society of Nephrology : JASN.