The association of alkaline phosphatase with fibrogenesis.

In a recent study of the healing of lesions in the gall-bladder of the cat, McMinn & Johnson (1957) were unable to demonstrate alkaline phosphatase in the new connective tissue that was formed during the repair process. This negative finding for phosphatase in new connective tissue is at variance with the results of Fell & Danielli (1943), who showed that there was a considerable increase in the amount of alkaline phosphatase associated with maturing granulation tissue during the healing of skin wounds in the rat. The present study was undertaken to determine whether these contrasting results in wound healing were due either to an organ difference, a species difference, or to some artefact arising during the carrying out of the histochemical technique.

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