Even low‐dose aspirin inhibits arachidonic acid–induced vasodilation in heart failure

There is some evidence that aspirin may be harmful to patients with congestive heart failure treated with angiotensin‐converting enzyme (ACE) inhibitors, but there has never been any direct examination of the vascular effects of aspirin in these patients. We sought to determine whether there is an arachidonic acid–dependent vasodilator pathway in resistance arteries in humans, whether it is affected by congestive heart failure, and whether it is inhibited by low‐dose aspirin.

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