Molecular Dissection of CD8+ T-Cell Dysfunction.
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[1] Todd M. Allen,et al. Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence , 2012, The Journal of experimental medicine.
[2] J. Altman,et al. Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function , 1998, The Journal of experimental medicine.
[3] Maxim N. Artyomov,et al. Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens , 2014, Nature.
[4] P. Sharma,et al. Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential , 2015, Cell.
[5] A. Regev,et al. Revealing the vectors of cellular identity with single-cell genomics , 2016, Nature Biotechnology.
[6] R. Bhadra,et al. Blimp-1–mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis , 2016, The Journal of experimental medicine.
[7] C. Sautès-Fridman,et al. Tertiary lymphoid structures in cancer and beyond. , 2014, Trends in immunology.
[8] Z. Trajanoski,et al. Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability. , 2016, Immunity.
[9] E. Zúñiga,et al. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. , 2009, Immunity.
[10] Ash A. Alizadeh,et al. Robust enumeration of cell subsets from tissue expression profiles , 2015, Nature Methods.
[11] E John Wherry,et al. Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection. , 2014, Immunity.
[12] E. Wherry,et al. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells , 2015, The Journal of experimental medicine.
[13] T. Graeber,et al. Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma. , 2016, The New England journal of medicine.
[14] L. Teyton,et al. Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection , 2005, Journal of Virology.
[15] E. Wherry,et al. Molecular and cellular insights into T cell exhaustion , 2015, Nature Reviews Immunology.
[16] Charles H. Yoon,et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.
[17] D. Speiser,et al. Regulatory circuits of T cell function in cancer , 2016, Nature Reviews Immunology.
[18] D. Brooks,et al. The role of IL-10 in regulating immunity to persistent viral infections. , 2011, Current topics in microbiology and immunology.
[19] B. Pulendran,et al. Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults , 2011, The Journal of Immunology.
[20] John T. Chang,et al. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA-seq , 2017, Nature Immunology.
[21] A. Zajac,et al. T‐cell exhaustion: characteristics, causes and conversion , 2010, Immunology.
[22] E. Wherry,et al. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. , 2009, Immunity.
[23] R. Zinkernagel,et al. Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection. , 1998, Immunity.
[24] G. Freeman,et al. Restoring function in exhausted CD8 T cells during chronic viral infection , 2006, Nature.
[25] Ludmila V. Danilova,et al. The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma , 2016, Cancer Immunology Research.
[26] Burton E. Barnett,et al. Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection , 2012, Science.
[27] Jedd D. Wolchok,et al. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy , 2016, Nature Reviews Clinical Oncology.
[28] T. Mak,et al. IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV , 2014, Cell Death and Differentiation.
[29] Susan M. Kaech,et al. Transcriptional control of effector and memory CD8+ T cell differentiation , 2012, Nature Reviews Immunology.
[30] W. Lim,et al. The Principles of Engineering Immune Cells to Treat Cancer , 2017, Cell.
[31] Pedro Romero,et al. Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. , 2011, The Journal of clinical investigation.
[32] Todd M. Allen,et al. The epigenetic landscape of T cell exhaustion , 2016, Science.
[33] Di Wu,et al. CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles , 2016, Nature Immunology.
[34] D. McGavern,et al. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells , 2011, The Journal of experimental medicine.
[35] Ting Ni,et al. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection , 2016, Nature.
[36] E. Wherry,et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. , 2007, Immunity.
[37] L. Berg,et al. IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection , 2015, PloS one.
[38] H. Lähdesmäki,et al. The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. , 2015, Immunity.
[39] Sandra P. Calderon-Copete,et al. T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. , 2016, Immunity.
[40] D. Speiser,et al. Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion , 2015, The EMBO journal.
[41] Le Cong,et al. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells , 2017, Cell.
[42] J. Sosman,et al. Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma , 2016, Cell.
[43] Benjamin Haibe-Kains,et al. CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. , 2013, The Journal of clinical investigation.
[44] S. Rosenberg,et al. Prospects for gene-engineered T cell immunotherapy for solid cancers , 2016, Nature Medicine.
[45] E John Wherry,et al. Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. , 2012, Immunity.
[46] K. Sauer,et al. IL-21 Is Required to Control Chronic Viral Infection , 2009, Science.
[47] T. Holderried,et al. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios , 2015, Science.
[48] スティーブン ジェイ. ブレイクモア,,et al. How to treat cancer , 2013 .
[49] Evan Z. Macosko,et al. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics , 2016, Cell.
[50] J. Ochando,et al. IL-6 Plays a Unique Role in Initiating c-Maf Expression during Early Stage of CD4 T Cell Activation1 , 2005, The Journal of Immunology.
[51] O. Lund,et al. T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection , 2014, PLoS pathogens.
[52] R. Ahmed,et al. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. , 2011, Immunity.
[53] G. Freeman,et al. Combination cancer immunotherapy and new immunomodulatory targets , 2015, Nature Reviews Drug Discovery.
[54] Björn Nilsson,et al. Integrative genomic analysis of HIV-specific CD8+ T cells reveals that PD-1 inhibits T cell function by upregulating BATF , 2010, Nature Medicine.
[55] S. Berger,et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade , 2016, Science.
[56] N. Pavlidis,et al. Improved outcome of high-risk early HER2 positive breast cancer with high CXCL13-CXCR5 messenger RNA expression. , 2012, Clinical breast cancer.
[57] A. Zajac,et al. A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection , 2009, Science.
[58] A. Snyder,et al. Acquired resistance to immunotherapy and future challenges , 2016, Nature Reviews Cancer.
[59] Matheus C. Bürger,et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy , 2016, Nature.
[60] Rolf M. Zinkernagel,et al. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells , 1993, Nature.
[61] N. Hiraoka,et al. Tertiary Lymphoid Organs in Cancer Tissues , 2016, Front. Immunol..
[62] J. Weber,et al. IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection , 2009, Science.
[63] Michael R. Speicher,et al. The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis , 2016, Science Translational Medicine.