The endocardial extent of reperfused first‐time myocardial infarction is more predictive of pathologic Q waves than is infarct transmurality: a magnetic resonance imaging study

Background  Historically, Q‐wave myocardial infarction (MI) has been equated with transmural MI. This association have, however, recently been rejected. The endocardial extent of MI is another potential determinant of pathological Q waves, since the first part of the QRS complex where the Q wave appears reflects depolarization of subendocardial myocardium. Therefore, the aim of the present study was to test the hypothesis that endocardial extent of MI is more predictive of pathological Q waves than is MI transmurality and to investigate the relationship between QRS scoring of the ECG and MI characteristics.

[1]  P. Kellman,et al.  Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm , 2006, Journal of magnetic resonance imaging : JMRI.

[2]  Einar Heiberg,et al.  Size and transmural extent of first-time reperfused myocardial infarction assessed by cardiac magnetic resonance can be estimated by 12-lead electrocardiogram. , 2005, American heart journal.

[3]  O. Pahlm,et al.  The relationship between electrical axis by 12-lead electrocardiogram and anatomical axis of the heart by cardiac magnetic resonance in healthy subjects. , 2005, American heart journal.

[4]  Jeroen J. Bax,et al.  Which parameters on magnetic resonance imaging determine Q waves on the electrocardiogram? , 2005, The American journal of cardiology.

[5]  J. Engvall,et al.  Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging , 2005, Scandinavian cardiovascular journal : SCJ.

[6]  P. Poole‐Wilson,et al.  The pathologic basis of Q-wave and non-Q-wave myocardial infarction: a cardiovascular magnetic resonance study. , 2004, Journal of the American College of Cardiology.

[7]  L. Shaw,et al.  Journal of Cardiovascular Magnetic Resonance Clinical Indications for Cardiovascular Magnetic Resonance (cmr): Consensus Panel Report , 2022 .

[8]  Richard D. White,et al.  Quantitative clinical assessment of chronic anterior myocardial infarction with delayed enhancement magnetic resonance imaging and QRS scoring. , 2003, American heart journal.

[9]  J. Oshinski,et al.  Imaging Time After Gd-DTPA Injection Is Critical in Using Delayed Enhancement to Determine Infarct Size Accurately With Magnetic Resonance Imaging , 2001, Circulation.

[10]  C. Lorenz,et al.  Measurement of the gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction. , 2001, Radiology.

[11]  Edwin Wu,et al.  Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction , 2001, The Lancet.

[12]  O. Simonetti,et al.  An improved MR imaging technique for the visualization of myocardial infarction. , 2001, Radiology.

[13]  O. Simonetti,et al.  Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. , 1999, Circulation.

[14]  C. Higgins,et al.  Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar MR imaging to quantify myocardial infarction: comparison with 99mTc-DTPA autoradiography in rats. , 1999, Radiology.

[15]  A. Moss,et al.  Q-wave versus non-Q wave myocardial infarction: a meaningless distinction. , 1999, Journal of the American College of Cardiology.

[16]  P M Rautaharju,et al.  Comparison of the various electrocardiographic scoring codes for estimating anatomically documented sizes of single and multiple infarcts of the left ventricle. , 1998, The American journal of cardiology.

[17]  K. Simon,et al.  Early and 1-year clinical outcome of patients evolving non-Q-wave versus Q-wave myocardial infarction after thrombolysis: results from the TIMI II study. , 1995, Circulation.

[18]  Maythem Saeed,et al.  Reperfused myocardial infarctions on T1‐ and susceptibility‐enhanced MRI: Evidence for loss of compartmentalization of contrast media , 1994, Magnetic resonance in medicine.

[19]  F. Prato,et al.  Measurement of the extraction efficiency and distribution volume for Gd‐DTPA in normal and diseased canine myocardium , 1993, Magnetic resonance in medicine.

[20]  T Nakatani,et al.  Determination of infarct size of acute myocardial infarction in dogs by magnetic resonance imaging and gadolinium-DTPA: comparison with indium-111 antimyosin imaging. , 1987, American journal of physiologic imaging.

[21]  Dwight E. Peake,et al.  Thrombolysis in myocardial infarction (TIMI) trial: Phase I. A comparison between intravenous tissue plasminogen activator and intravenous streptokinase , 1988 .

[22]  R Roberts,et al.  Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. , 1987, Circulation.

[23]  R E Ideker,et al.  Evaluation of a QRS scoring system for estimating myocardial infarct size. V. Specificity and method of application of the complete system. , 1985, The American journal of cardiology.

[24]  R E Ideker,et al.  Evaluation of a QRS scoring system for estimating myocardial infarct size. IV. Correlation with quantitative anatomic findings for posterolateral infarcts. , 1983, The American journal of cardiology.

[25]  R. Ideker,et al.  Evaluation of a QRS scoring system for estimating myocardial infarct size. III. Correlation with quantitative anatomic findings for inferior infarcts. , 1984, The American journal of cardiology.

[26]  D. Spodick PTCA: need for prospective randomized controlled trials. , 1983, The American journal of cardiology.

[27]  D. Spodick Q-wave infarction versus S-T infarction. Nonspecificity of electrocardiographic criteria for differentiating transmural and nontransmural lesions. , 1983, The American journal of cardiology.

[28]  B. Phibbs "Transmural" versus "subendocardial" myocardial infarction: an electrocardiographic myth. , 1983, Journal of the American College of Cardiology.

[29]  R. Ideker,et al.  Evaluation of a QRS scoring system for estimating myocardial infarct size. II. Correlation with quantitative anatomic findings for anterior infarcts. , 1982, The American journal of cardiology.

[30]  H. Pipberger,et al.  "Silent" subendocardial infarcts: fact or fiction? , 1980, American heart journal.

[31]  D. Durrer,et al.  Total Excitation of the Isolated Human Heart , 1970, Circulation.

[32]  M. Maxwell,et al.  Studies on the mechanism of ventricular activity. VI. The depolarization complex in pure subendocardial infarction; role of the subendocardial region in the normal electrocardiogram. , 1954, The American journal of medicine.