Nanobubbles for therapeutic delivery: Production, stability and current prospects

[1]  E Stride,et al.  Microbubble ultrasound contrast agents: A review , 2003, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[2]  Jürgen K Willmann,et al.  Acoustic and Photoacoustic Molecular Imaging of Cancer , 2013, The Journal of Nuclear Medicine.

[3]  A. Exner,et al.  Porphyrin-Loaded Pluronic Nanobubbles: A New US-Activated Agent for Future Theranostic Applications. , 2018, Bioconjugate chemistry.

[4]  Muhammad Saad Khan,et al.  Engineering oxygen nanobubbles for the effective reversal of hypoxia , 2018, Artificial cells, nanomedicine, and biotechnology.

[5]  D. Staub,et al.  Contrast-enhanced ultrasound: clinical applications in patients with atherosclerosis , 2015, The International Journal of Cardiovascular Imaging.

[6]  L. Kong,et al.  Regulation of HbPIP2;3, a Latex-Abundant Water Transporter, Is Associated with Latex Dilution and Yield in the Rubber Tree (Hevea brasiliensis Muell. Arg.) , 2015, PloS one.

[7]  Sarah B. Murthi,et al.  Ultrasound Physics and Equipment , 2010 .

[8]  M. Longo,et al.  Dissolution behavior of lipid monolayer-coated, air-filled microbubbles: Effect of lipid hydrophobic chain length , 2002 .

[9]  J. Bamber,et al.  Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging , 2017, 2017 IEEE International Ultrasonics Symposium (IUS).

[10]  H. Yoshikawa,et al.  Oxygen and Air Nanobubble Water Solution Promote the Growth of Plants, Fishes, and Mice , 2013, PloS one.

[11]  J. Swenson,et al.  Differentiating bulk nanobubbles from nanodroplets and nanoparticles , 2021, Current Opinion in Colloid & Interface Science.

[12]  T. Tuziuti,et al.  Mysteries of bulk nanobubbles (ultrafine bubbles); stability and radical formation. , 2018, Ultrasonics sonochemistry.

[13]  Richard Manasseh,et al.  Cavitation microstreaming and stress fields created by microbubbles. , 2010, Ultrasonics.

[14]  G. Winter,et al.  New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: in-vivo characterization. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[15]  G. Baronzio,et al.  Overview of Methods for Overcoming Hindrance to Drug Delivery to Tumors, with Special Attention to Tumor Interstitial Fluid , 2015, Front. Oncol..

[16]  R. Cavalli,et al.  Ultrasound-mediated oxygen delivery from chitosan nanobubbles. , 2009, International journal of pharmaceutics.

[17]  M. Borden,et al.  Lipid monolayer collapse and microbubble stability. , 2012, Advances in colloid and interface science.

[18]  A. Exner,et al.  Concurrent visual and acoustic tracking of passive and active delivery of nanobubbles to tumors , 2020, Theranostics.

[19]  Li Zhang,et al.  The Optimized Fabrication of a Novel Nanobubble for Tumor Imaging , 2019, Front. Pharmacol..

[20]  Daijia Shen,et al.  Preparation Of Nanobubbles Modified With A Small-Molecule CXCR4 Antagonist For Targeted Drug Delivery To Tumors And Enhanced Ultrasound Molecular Imaging , 2019, International journal of nanomedicine.

[21]  Nicola Ingram,et al.  Organ on chip models for the evaluation of microbubble based therapeutic delivery , 2020, BiOS.

[22]  Paul S. Sheeran,et al.  Imaging Methods for Ultrasound Contrast Agents. , 2019, Ultrasound in medicine & biology.

[23]  Rajeet Chandan,et al.  Pro-apoptotic liposomes-nanobubble conjugate synergistic with paclitaxel: a platform for ultrasound responsive image-guided drug delivery , 2018, Scientific Reports.

[24]  J. Bosch,et al.  Microbubble Composition and Preparation for High-Frequency Contrast-Enhanced Ultrasound Imaging: In Vitro and In Vivo Evaluation , 2017, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[25]  Chunxiang Xu,et al.  Dynamic tracking of bulk nanobubbles from microbubbles shrinkage to collapse , 2020 .

[26]  Nico de Jong,et al.  Basic Acoustic Properties of Microbubbles , 2002, Echocardiography.

[27]  A. Garnier-Suillerot,et al.  Comparison of the interaction of doxorubicin, daunorubicin, idarubicin and idarubicinol with large unilamellar vesicles. Circular dichroism study. , 1998, Biochimica et biophysica acta.

[28]  R. D. Venter,et al.  THE STABILITY OF GAS BUBBLES IN LIQUID‐GAS SOLUTIONS * , 1983 .

[29]  A. Exner,et al.  Time-intensity-curve Analysis and Tumor Extravasation of Nanobubble Ultrasound Contrast Agents. , 2019, Ultrasound in medicine & biology.

[30]  Dong Wang,et al.  Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2 aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer , 2018, Drug delivery.

[31]  D. Lohse,et al.  Diffusive shielding stabilizes bulk nanobubble clusters. , 2011, Chemphyschem : a European journal of chemical physics and physical chemistry.

[32]  A. Exner,et al.  Increasing Doxorubicin Loading in Lipid-Shelled Perfluoropropane Nanobubbles via a Simple Deprotonation Strategy , 2020, Frontiers in Pharmacology.

[33]  S. Peyman,et al.  Evaluation of lipid-stabilised tripropionin nanodroplets as a delivery route for combretastatin A4. , 2017, International journal of pharmaceutics.

[34]  P. Giustetto,et al.  Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents. , 2015, Colloids and surfaces. B, Biointerfaces.

[35]  Wei Wang,et al.  pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment , 2014, Cancer biology & medicine.

[36]  Ding Ding,et al.  Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors. , 2018, ACS nano.

[37]  R. Sullivan,et al.  Immune Effects of Chemotherapy, Radiation, and Targeted Therapy and Opportunities for Combination With Immunotherapy. , 2015, Seminars in oncology.

[38]  R. Zheng,et al.  Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. , 2013, Biomaterials.

[39]  Jiajia Xue,et al.  A Colorimetric Enzyme-Linked Immunosorbent Assay with CuO Nanoparticles as Signal Labels Based on the Growth of Gold Nanoparticles In Situ , 2018, Nanomaterials.

[40]  M. Lazdunski,et al.  The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia , 2018, Scientific Reports.

[41]  M. Alheshibri,et al.  A History of Nanobubbles. , 2016, Langmuir : the ACS journal of surfaces and colloids.

[42]  Zhigang Wang,et al.  Methotrexate-loaded PLGA nanobubbles for ultrasound imaging and Synergistic Targeted therapy of residual tumor during HIFU ablation. , 2014, Biomaterials.

[43]  G. Gravante,et al.  Targeted microbubbles in the experimental and clinical setting. , 2012, American journal of surgery.

[44]  C. Holland,et al.  Thrombolytic efficacy of tissue plasminogen activator-loaded echogenic liposomes in a rabbit thrombus model. , 2012, Thrombosis research.

[45]  P. Giustetto,et al.  Preparation and characterization of dextran nanobubbles for oxygen delivery. , 2009, International journal of pharmaceutics.

[46]  W. Pitt,et al.  Acoustic Droplet Vaporization in Biology and Medicine , 2013, BioMed research international.

[47]  C. Shapiro,et al.  Side effects of adjuvant treatment of breast cancer. , 2001, The New England journal of medicine.

[48]  Khaled Greish,et al.  Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. , 2010, Methods in molecular biology.

[49]  M. Borden,et al.  Ligand conjugation to bimodal poly(ethylene glycol) brush layers on microbubbles. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[50]  Hong Liu,et al.  Cell-penetrating peptide-siRNA conjugate loaded YSA-modified nanobubbles for ultrasound triggered siRNA delivery. , 2015, Colloids and surfaces. B, Biointerfaces.

[51]  Y. Kono,et al.  Contrast-Enhanced Ultrasound of Focal Liver Masses: A Success Story. , 2020, Ultrasound in medicine & biology.

[52]  Ping Wang,et al.  Nanobubbles for enhanced ultrasound imaging of tumors , 2012, International journal of nanomedicine.

[53]  Pamela F. Jones,et al.  Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues , 2020, Theranostics.

[54]  R. Schubert,et al.  Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient. , 2006, Biochimica et biophysica acta.

[55]  Phoebe L Stewart,et al.  Cryo-EM Visualization of Lipid and Polymer-Stabilized Perfluorocarbon Gas Nanobubbles - A Step Towards Nanobubble Mediated Drug Delivery , 2017, Scientific Reports.

[56]  Jae Young Lee,et al.  Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS. , 2020, Ultrasound in medicine & biology.

[57]  Dan Xu,et al.  Anti-G250 nanobody-functionalized nanobubbles targeting renal cell carcinoma cells for ultrasound molecular imaging , 2020, Nanotechnology.

[58]  Yong Li,et al.  Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression , 2014, Nature Communications.

[59]  C. Holland,et al.  Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression , 2016, Journal of liposome research.

[60]  Michael C. Kolios,et al.  Theoretical and experimental investigation of the nonlinear dynamics of nanobubbles excited at clinically relevant ultrasound frequencies and pressures: The role oflipid shell buckling , 2017, 2017 IEEE International Ultrasonics Symposium (IUS).

[61]  S. Evans,et al.  Poly(ethylene glycol) lipid-shelled microbubbles: abundance, stability, and mechanical properties. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[62]  D. Lohse,et al.  Universal Equations for the Coalescence Probability and Long-Term Size Stability of Phospholipid-Coated Monodisperse Microbubbles Formed by Flow Focusing. , 2017, Langmuir : the ACS journal of surfaces and colloids.

[63]  Yu Wang,et al.  Biosynthetic nanobubbles for targeted gene delivery by focused ultrasound. , 2019, Nanoscale.

[64]  Lianhua Zhu,et al.  Inhibition of prostate cancer growth using doxorubicin assisted by ultrasound-targeted nanobubble destruction , 2016, International journal of nanomedicine.

[65]  Nico de Jong,et al.  Acoustical response of DSPC versus DPPC lipid-coated microbubbles , 2013, 2013 IEEE International Ultrasonics Symposium (IUS).

[66]  K. Tachibana,et al.  Echographic and physical characterization of albumin-stabilized nanobubbles , 2019, Heliyon.

[67]  J. Swenson,et al.  Size and Refractive Index determination of Sub-Wavelength Particles and Air Bubbles by Holographic Nanoparticle Tracking Analysis. , 2019, Analytical chemistry.

[68]  Kristian Pietras,et al.  High interstitial fluid pressure — an obstacle in cancer therapy , 2004, Nature Reviews Cancer.

[69]  Kishan Dholakia,et al.  Membrane disruption by optically controlled microbubble cavitation , 2005 .

[70]  B. Krajewska,et al.  Chitosan as a lipid binder: a langmuir monolayer study of chitosan-lipid interactions. , 2007, Biomacromolecules.

[71]  Ralf Seip,et al.  Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[72]  W. Cheng,et al.  Apatinib-loaded lipid nanobubbles combined with ultrasound-targeted nanobubble destruction for synergistic treatment of HepG2 cells in vitro , 2018, OncoTargets and therapy.

[73]  Tingting Li,et al.  Multifunctional PLGA Nanobubbles as Theranostic Agents: Combining Doxorubicin and P-gp siRNA Co-Delivery Into Human Breast Cancer Cells and Ultrasound Cellular Imaging. , 2015, Journal of biomedical nanotechnology.

[74]  A. Pacek,et al.  On the Existence and Stability of Bulk Nanobubbles. , 2018, Langmuir : the ACS journal of surfaces and colloids.

[75]  Zhanwen Xing,et al.  The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging , 2010, Nanotechnology.

[76]  Nico de Jong,et al.  Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[77]  Sevan Harput,et al.  Increasing the sonoporation efficiency of targeted polydisperse microbubble populations using chirp excitation , 2013, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[78]  Jie. Zhu,et al.  Cleaning with Bulk Nanobubbles. , 2016, Langmuir : the ACS journal of surfaces and colloids.

[79]  A. Exner,et al.  CHAPTER THREE Ultrasound Contrast Agents and Delivery Systems in Cancer Detection and Therapy , 2018, Advances in cancer research.

[80]  Muhammad Saad Khan,et al.  Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications , 2019, Nanomaterials.

[81]  Michael C. Kolios,et al.  Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles. , 2019, Nanoscale.

[82]  John F. Callan,et al.  Gemcitabine loaded microbubbles for targeted chemo‐sonodynamic therapy of pancreatic cancer , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[83]  R. Cavalli,et al.  Doxorubicin-Loaded Nanobubbles Combined with Extracorporeal Shock Waves: Basis for a New Drug Delivery Tool in Anaplastic Thyroid Cancer. , 2016, Thyroid.

[84]  A. Molinari,et al.  Liposomes as nanomedical devices , 2015, International journal of nanomedicine.

[85]  Elisavet D. Michailidi,et al.  Bulk nanobubbles: Production and investigation of their formation/stability mechanism. , 2019, Journal of colloid and interface science.

[86]  P. Laurinmäki,et al.  Gold-embedded photosensitive liposomes for drug delivery: triggering mechanism and intracellular release. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[87]  R K Jain,et al.  Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. , 1990, Cancer research.

[88]  H. Maeda,et al.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. , 1986, Cancer research.

[89]  Damien V. B. Batchelor,et al.  High-throughput microfluidics for evaluating microbubble enhanced delivery of Cancer therapeutics in spheroid cultures. , 2020, Journal of controlled release : official journal of the Controlled Release Society.

[90]  S. Peyman,et al.  On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging. , 2016, Lab on a chip.

[91]  D. Longo,et al.  Bcl-2 – mediated Drug Resistance : Inhibition of Apoptosis by Blocking Nuclear Factor of Activated T Lymphocytes ( NFAT )-induced Fas Ligand Transcription , 1999 .

[92]  Lianhua Zhu,et al.  Construction of ultrasonic nanobubbles carrying CAIX polypeptides to target carcinoma cells derived from various organs , 2017, Journal of Nanobiotechnology.

[93]  A. Pacek,et al.  Interpreting the interfacial and colloidal stability of bulk nanobubbles. , 2018, Soft matter.

[94]  Monika Janda,et al.  Systematic Review of Interventions to Improve the Provision of Information for Adults with Primary Brain Tumors and Their Caregivers , 2014, Front. Oncol..

[95]  Nico de Jong,et al.  Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[96]  F J Ten Cate,et al.  Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter clinical results. , 1990, Journal of the American College of Cardiology.

[97]  Hebao Yuan,et al.  Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations. , 2017, International journal of pharmaceutics.

[98]  H. Harashima,et al.  Liposome Clearance , 2002, Bioscience reports.

[99]  J. Willmann,et al.  Ultrasound-guided drug delivery in cancer , 2017, Ultrasonography.

[100]  Lianhua Zhu,et al.  CAIX aptamer-functionalized targeted nanobubbles for ultrasound molecular imaging of various tumors , 2018, International journal of nanomedicine.

[101]  Jinwoo Cheon,et al.  Recent advances of magneto-thermal capabilities of nanoparticles: From design principles to biomedical applications , 2017 .

[102]  S. Kawakami,et al.  The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection , 2017, Drug delivery.

[103]  B. Basilia,et al.  Nanobubbles from Ethanol-Water Mixtures: Generation and Solute Effects via Solvent Replacement Method , 2018, ChemistrySelect.

[104]  J. Velázquez-Fernández,et al.  Nanomedicine review: clinical developments in liposomal applications , 2019 .

[105]  Lianhua Zhu,et al.  G250 Antigen-Targeting Drug-Loaded Nanobubbles Combined with Ultrasound Targeted Nanobubble Destruction: A Potential Novel Treatment for Renal Cell Carcinoma , 2020, International journal of nanomedicine.

[106]  N. Bunkin,et al.  Nanobubble clusters of dissolved gas in aqueous solutions of electrolyte. II. Theoretical interpretation. , 2012, The Journal of chemical physics.

[107]  D. Rak,et al.  Comment on "Bulk Nanobubbles or Not Nanobubbles: That is the Question". , 2020, Langmuir : the ACS journal of surfaces and colloids.

[108]  Yun-qiang Wang,et al.  Interaction of γ-Fe2O3 nanoparticles with Citrus maxima leaves and the corresponding physiological effects via foliar application , 2017, Journal of Nanobiotechnology.

[109]  François Tranquart,et al.  First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer: A Safety and Feasibility Pilot Study , 2017, Investigative radiology.

[110]  D. Belnap,et al.  Encapsulating nanoemulsions inside eLiposomes for ultrasonic drug delivery. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[111]  R K Jain,et al.  Openings between defective endothelial cells explain tumor vessel leakiness. , 2000, The American journal of pathology.

[112]  Hong Liu,et al.  Cell-penetrating peptide-doxorubicin conjugate loaded NGR-modified nanobubbles for ultrasound triggered drug delivery , 2016, Journal of drug targeting.

[113]  Kazunari Ohgaki,et al.  Physicochemical approach to nanobubble solutions , 2010 .

[114]  S. Wilhelm,et al.  The entry of nanoparticles into solid tumours , 2020, Nature Materials.

[115]  W. Shufang,et al.  Effects of micro-nano bubble aerated irrigation and nitrogen fertilizer level on tillering, nitrogen uptake and utilization of early rice , 2018, Plant, Soil and Environment.

[116]  A. Exner,et al.  Effect of Bubble Concentration on the in Vitro and in Vivo Performance of Highly Stable Lipid Shell-Stabilized Micro- and Nanoscale Ultrasound Contrast Agents. , 2019, Langmuir : the ACS journal of surfaces and colloids.

[117]  A. Exner,et al.  Improving performance of nanoscale ultrasound contrast agents using N,N-diethylacrylamide stabilization. , 2017, Nanomedicine : nanotechnology, biology, and medicine.

[118]  N. de Jong,et al.  20 years of ultrasound contrast agent modeling , 2013, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[119]  Trushar R. Patel,et al.  Dynamic light scattering: a practical guide and applications in biomedical sciences , 2016, Biophysical Reviews.

[120]  I. Tannock,et al.  Drug penetration in solid tumours , 2006, Nature Reviews Cancer.

[121]  R. Müller,et al.  Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. , 2001, Advanced drug delivery reviews.

[122]  Yanli Guo,et al.  Ultrasonic Nanobubbles Carrying Anti-PSMA Nanobody: Construction and Application in Prostate Cancer-Targeted Imaging , 2015, PloS one.

[123]  E. Stride,et al.  Microbubble-Mediated Delivery for Cancer Therapy , 2018, Fluids.

[124]  Damien V. B. Batchelor,et al.  Nested Nanobubbles for Ultrasound-Triggered Drug Release , 2020, ACS applied materials & interfaces.

[125]  Werner Lauterborn,et al.  Physics of bubble oscillations , 2010 .

[126]  Xue Shen,et al.  Charge-reversal-functionalized PLGA nanobubbles as theranostic agents for ultrasonic-imaging-guided combination therapy. , 2018, Biomaterials science.

[127]  Michael C. Kolios,et al.  Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique , 2018, Nanoscale.

[128]  Luis Solorio,et al.  Formulation and characterization of echogenic lipid-Pluronic nanobubbles. , 2009, Molecular pharmaceutics.

[129]  H. Maeda,et al.  Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[130]  S. Yao,et al.  pH-Responsive Oxygen Nanobubbles for Spontaneous Oxygen Delivery in Hypoxic Tumors. , 2019, Langmuir : the ACS journal of surfaces and colloids.

[131]  Li Wang,et al.  Corrigendum: The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes , 2016, Scientific reports.

[132]  Dong-Jin Lim,et al.  Gold Nanoparticles for Photothermal Cancer Therapy , 2019, Front. Chem..

[133]  Vassilis Sboros,et al.  In Vitro Acoustic Characterization of Three Phospholipid Ultrasound Contrast Agents from 12 to 43 MHz , 2014, Ultrasound in medicine & biology.

[134]  Nico de Jong,et al.  Increasing the Endothelial Layer Permeability Through Ultrasound-Activated Microbubbles , 2010, IEEE Transactions on Biomedical Engineering.

[135]  Paul A. Dayton,et al.  Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy , 2018, Theranostics.

[136]  D. Jayne,et al.  Nanoparticle loaded hydrogel for the light-activated release and photothermal enhancement of antimicrobial peptides. , 2020, ACS applied materials & interfaces.

[137]  Damien V. B. Batchelor,et al.  Evaluating Phospholipid-Functionalized Gold Nanorods for In Vivo Applications. , 2021, Small.

[138]  M. Eremets,et al.  Ammonia as a case study for the spontaneous ionization of a simple hydrogen-bonded compound , 2014, Nature Communications.

[139]  S. Peyman,et al.  Characterisation of Liposome-Loaded Microbubble Populations for Subharmonic Imaging. , 2017, Ultrasound in medicine & biology.

[140]  Hong Liu,et al.  Thermosensitive magnetic liposomes with doxorubicin cell-penetrating peptides conjugate for enhanced and targeted cancer therapy , 2016, Drug delivery.

[141]  Muhammad Saad Khan,et al.  Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells , 2019, Cancers.

[142]  T. Tuziuti,et al.  The influence of storage conditions and container materials on the long term stability of bulk nanobubbles — Consideration from a perspective of interactions between bubbles and surroundings , 2020 .

[143]  Haipeng Tong,et al.  Preparation of Nanobubbles Carrying Androgen Receptor siRNA and Their Inhibitory Effects on Androgen-Independent Prostate Cancer when Combined with Ultrasonic Irradiation , 2014, PloS one.

[144]  Nikolay M. Borisov,et al.  Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs , 2019, Front. Pharmacol..

[145]  Collin T. Inglut,et al.  Immunological and Toxicological Considerations for the Design of Liposomes , 2020, Nanomaterials.

[146]  Hailong Liu,et al.  Effectiveness of the Young-Laplace equation at nanoscale , 2016, Scientific Reports.

[147]  Michael C. Kolios,et al.  Theoretical and experimental investigation of the nonlinear dynamics of nanobubbles excited at clinically relevant ultrasound frequencies and pressures: The role of lipid shell buckling , 2017, 2017 IEEE International Ultrasonics Symposium (IUS).

[148]  R. Advíncula,et al.  Role of Surface Tension in Gas Nanobubble Stability Under Ultrasound. , 2018, ACS applied materials & interfaces.

[149]  G. Barratt,et al.  Remote loading of doxorubicin into liposomes by transmembrane pH gradient to reduce toxicity toward H9c2 cells , 2015, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

[150]  William Henry,et al.  III. Experiments on the quantity of gases absorbed by water, at different temperatures, and under different pressures , 1803, Philosophical Transactions of the Royal Society of London.

[151]  E. Reimhult,et al.  Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes , 2016, Materials.

[152]  F. Xing,et al.  Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal , 2020, Frontiers in Pharmacology.

[153]  A. Exner,et al.  Enhancing Tumor Drug Distribution With Ultrasound-Triggered Nanobubbles. , 2019, Journal of pharmaceutical sciences.

[154]  K. Hynynen,et al.  Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation. , 2020, Nano letters.

[155]  Michael C. Kolios,et al.  Theoretical and Experimental Gas Volume Quantification of Micro- and Nanobubble Ultrasound Contrast Agents , 2020, Pharmaceutics.

[156]  S. Esener,et al.  A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[157]  G. Zheng,et al.  Threshold-dependent nonlinear scattering from porphyrin nanobubbles for vascular and extravascular applications , 2018, Physics in medicine and biology.

[158]  S. Evans,et al.  Stimuli-Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle-Associated Drug-Delivery Systems. , 2018, Macromolecular bioscience.

[159]  C. Yeh,et al.  Aptamer-conjugated nanobubbles for targeted ultrasound molecular imaging. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[160]  C. Ohl,et al.  How Bulk Nanobubbles Might Survive. , 2020, Physical review letters.

[161]  S. Evans,et al.  Polyelectrolyte complex templated synthesis of monodisperse, sub-100 nm porous silica nanoparticles for cancer targeted and stimuli-responsive drug delivery. , 2020, Journal of colloid and interface science.

[162]  M. Trotta,et al.  New chitosan nanobubbles for ultrasound-mediated gene delivery: preparation and in vitro characterization , 2012, International journal of nanomedicine.

[163]  S. Andrade,et al.  Colour discrimination thresholds in type 1 Bipolar Disorder: a pilot study , 2017, Scientific Reports.

[164]  R. Zheng,et al.  Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes. , 2014, Biomaterials.

[165]  Hong Liu,et al.  Ultrasound-responsive nanobubbles contained with peptide–camptothecin conjugates for targeted drug delivery , 2016, Drug delivery.

[166]  Steven Freear,et al.  Expanding 3D geometry for enhanced on-chip microbubble production and single step formation of liposome modified microbubbles. , 2012, Lab on a chip.

[167]  Feng Liu,et al.  Folate-conjugated nanobubbles selectively target and kill cancer cells via ultrasound-triggered intracellular explosion. , 2018, Biomaterials.

[168]  R. Banerjee,et al.  Nanobubble Liposome Complexes for Diagnostic Imaging and Ultrasound-Triggered Drug Delivery in Cancers: A Theranostic Approach , 2019, ACS omega.