In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes

[1]  F. Worek,et al.  Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes. , 2013, Chemico-biological interactions.

[2]  J. D. Figueroa-Villar,et al.  The effect of neutral oximes on the reactivation of human acetylcholinesterase inhibited with paraoxon , 2012 .

[3]  F. Worek,et al.  Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships. , 2012, Biochemical pharmacology.

[4]  Yun Chen,et al.  Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies. , 2012, Neurotoxicology.

[5]  F. Worek,et al.  Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase. , 2012, Toxicology letters.

[6]  P. Renard,et al.  Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. , 2012, Accounts of chemical research.

[7]  P. Renard,et al.  Design, Synthesis and Evaluation of New α‐Nucleophiles for the Hydrolysis of Organophosphorus Nerve Agents: Application to the Reactivation of Phosphorylated Acetylcholinesterase. , 2011 .

[8]  F. Worek,et al.  In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species. , 2011, Toxicology letters.

[9]  M. P. Kaushik,et al.  Synthesis and in vitro evaluation of xylene linked carbamoyl bis-pyridinium monooximes as reactivators of organophosphorus (OP) inhibited electric eel acetylcholinesterase (AChE). , 2011, European journal of medicinal chemistry.

[10]  P. Renard,et al.  Design, synthesis and evaluation of new α-nucleophiles for the hydrolysis of organophosphorus nerve agents: application to the reactivation of phosphorylated acetylcholinesterase , 2011 .

[11]  Kibong Kim,et al.  Destruction and detection of chemical warfare agents. , 2011, Chemical reviews.

[12]  J. Cashman,et al.  Amidine-oximes: reactivators for organophosphate exposure. , 2011, Journal of medicinal chemistry.

[13]  A. Srivastava,et al.  In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[14]  V. Dohnal,et al.  Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking. , 2011, Bioorganic & medicinal chemistry.

[15]  V. Dohnal,et al.  Monooxime‐monocarbamoyl Bispyridinium Xylene‐Linked Reactivators of Acetylcholinesterase—Synthesis, In vitro and Toxicity Evaluation, and Docking Studies , 2010, ChemMedChem.

[16]  S. Bharate,et al.  Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. , 2010, Bioorganic & medicinal chemistry.

[17]  K. Kuča,et al.  In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase , 2009, Clinical toxicology.

[18]  M. Prostran,et al.  Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. , 2009, Current medicinal chemistry.

[19]  K. Kuča,et al.  Efficacy of Eight Experimental Bispyridinium Oximes Against Paraoxon-Induced Mortality: Comparison with the Conventional Oximes Pralidoxime and Obidoxime , 2009, Neurotoxicity Research.

[20]  K. Kuča,et al.  Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. , 2008, Chemico-biological interactions.

[21]  K. Kuča,et al.  Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases. , 2008, Chemico-biological interactions.

[22]  G. Petroianu,et al.  Entry of oximes into the brain: a review. , 2008, Current medicinal chemistry.

[23]  A. Gupta,et al.  In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages. , 2008, Toxicology in vitro : an international journal published in association with BIBRA.

[24]  N. Park,et al.  New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase. , 2007, Bioorganic & medicinal chemistry.

[25]  K. Kuča,et al.  Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). , 2007, Journal of medicinal chemistry.

[26]  V. Dohnal,et al.  Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. , 2007, Bioorganic & medicinal chemistry letters.

[27]  Kamil Kuca,et al.  Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction. , 2007, Mini reviews in medicinal chemistry.

[28]  François Terrier,et al.  Revisiting the reactivity of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of sarin, soman and DFP under mild conditions. , 2006, Organic & biomolecular chemistry.

[29]  V. Dohnal,et al.  Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. , 2006, Bioorganic & medicinal chemistry letters.

[30]  K. Kuča,et al.  Structural requirements of acetylcholinesterase reactivators. , 2006, Mini reviews in medicinal chemistry.

[31]  V. Dohnal,et al.  New methods in synthesis of acetylcholinesterase reactivators and evaluation of their potency to reactivate cyclosarin-inhibited AChE , 2006 .

[32]  R. Ramaraj,et al.  Micellar catalysis on the electron transfer reactions of iron(III)-polypyridyl complexes with organic sulfides-importance of hydrophobic interactions. , 2006, Organic & biomolecular chemistry.

[33]  K. Kuča,et al.  New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications. , 2005, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[34]  P. Eyer,et al.  Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. , 2004, Biochemical pharmacology.

[35]  K. Kuča,et al.  Synthesis of a potential reactivator of acetylcholinesterase—1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)propane dibromide , 2003 .

[36]  Franz Worek,et al.  Molar absorption coefficients for the reduced Ellman reagent: reassessment. , 2003, Analytical biochemistry.

[37]  V. Tõugu.  Acetylcholinesterase Mechanism of catalysis and inhibition , 2001 .

[38]  P. Eyer,et al.  Improved determination of acetylcholinesterase activity in human whole blood. , 1999, Clinica chimica acta; international journal of clinical chemistry.

[39]  P. Eyer,et al.  Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases , 1998, Archives of Toxicology.

[40]  P. H. Wang,et al.  Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds. , 1986, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[41]  E. Wang,et al.  Oxime reactivation of diethylphosphoryl human serum cholinesterase. , 1967, The Journal of biological chemistry.

[42]  I. B. Wilson.  Acetylcholinesterase. XI. Reversibility of tetraethyl pyrophosphate. , 1951, Journal of Biological Chemistry.

[43]  J. McDonough,et al.  Treatment with Tertiary Oximes Prevents Seizures and Improves Survival Following Sarin Intoxication , 2009, Journal of Molecular Neuroscience.

[44]  K. Kuča,et al.  Synthesis of Bisquaternary Symmetric - X,δ-Bis(2-Hydroxyiminomethylpyridinium) Alkane Dibromides and Their Reactivation of Cyclosarin-Inhibited Acetylcholinesterase , 2004 .

[45]  J. Kassa,et al.  Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice. , 1996, Acta medica.

[46]  江藤 守総.  Organophosphorus pesticides : organic and biological chemistry , 1974 .

[47]  E. Reiner,et al.  Enzyme inhibitors as substrates : interactions of esterases with esters of organophosphorus and carbamic acids , 1972 .

[48]  A. L. Green,et al.  The reactivation of cholinesterase inhibited with organophosphorus compounds. 2. Reactivation by pyridinealdoxime methiodides. , 1958, The Biochemical journal.

[49]  A. L. Green,et al.  The reactivation of cholinesterase inhibited with organophosphorus compounds. I. Reactivation by 2-oxoaldoximes. , 1958, The Biochemical journal.

[50]  B. Ginsburg,et al.  A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase. , 1955, Biochimica et biophysica acta.