IL‐6 regulates exercise and training‐induced adaptations in subcutaneous adipose tissue in mice

Aim:  The aim of this study was to test the hypothesis that IL‐6 regulates exercise‐induced gene responses in subcutaneous adipose tissue in mice.

[1]  H. Pilegaard,et al.  Interleukin‐6 modifies mRNA expression in mouse skeletal muscle , 2011, Acta physiologica.

[2]  B. Pedersen,et al.  Exercise‐induced liver chemokine CXCL‐1 expression is linked to muscle‐derived interleukin‐6 expression , 2011, The Journal of physiology.

[3]  C. Mantzoros,et al.  Leptin in human physiology and therapeutics , 2010, Frontiers in Neuroendocrinology.

[4]  D. Dyck,et al.  The interaction between adipokines, diet and exercise on muscle insulin sensitivity , 2010, Current opinion in clinical nutrition and metabolic care.

[5]  Zhenggang Yang,et al.  Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1* , 2010, The Journal of Biological Chemistry.

[6]  M. White,et al.  Human IL6 enhances leptin action in mice , 2009, Diabetologia.

[7]  S. Fried,et al.  Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. , 2009, American journal of physiology. Endocrinology and metabolism.

[8]  V. Vieira,et al.  Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. , 2009, American journal of physiology. Endocrinology and metabolism.

[9]  N. Ruderman,et al.  AMPK and the biochemistry of exercise: implications for human health and disease. , 2009, The Biochemical journal.

[10]  E. Ropelle,et al.  Central Exercise Action Increases the AMPK and mTOR Response to Leptin , 2008, PloS one.

[11]  Julie Gehl,et al.  Physiological effects of high- and low-voltage pulse combinations for gene electrotransfer in muscle. , 2008, Human gene therapy.

[12]  D Miklavcic,et al.  Efficiency of high- and low-voltage pulse combinations for gene electrotransfer in muscle, liver, tumor, and skin. , 2008, Human gene therapy.

[13]  M. Febbraio,et al.  Muscle as an endocrine organ: focus on muscle-derived interleukin-6. , 2008, Physiological reviews.

[14]  Y. Hellsten,et al.  Absence of humoral mediated 5′AMP‐activated protein kinase activation in human skeletal muscle and adipose tissue during exercise , 2007, The Journal of physiology.

[15]  F. Dela,et al.  Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. , 2007, European journal of endocrinology.

[16]  A. Petridou,et al.  Long-term exercise increases the DNA binding activity of peroxisome proliferator-activated receptor gamma in rat adipose tissue. , 2007, Metabolism: clinical and experimental.

[17]  J. Balschi,et al.  Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. , 2007, The Biochemical journal.

[18]  B. Pedersen,et al.  The role of IL-6 in mediating the anti-inflammatory effects of exercise. , 2006, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[19]  E. Ropelle,et al.  Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats , 2006, Diabetes.

[20]  V. Vieira,et al.  Exercise, inflammation, and innate immunity. , 2006, Neurologic clinics.

[21]  K. Takekoshi,et al.  Long-term exercise stimulates adenosine monophosphate-activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver. , 2006, Metabolism: clinical and experimental.

[22]  M. Febbraio,et al.  Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. , 2006, American journal of physiology. Endocrinology and metabolism.

[23]  A. Steensberg,et al.  Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle. , 2005, Journal of applied physiology.

[24]  M. Gurnell Peroxisome proliferator-activated receptor gamma and the regulation of adipocyte function: lessons from human genetic studies. , 2005, Best practice & research. Clinical endocrinology & metabolism.

[25]  Karim Bouzakri,et al.  Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. , 2005, Diabetes.

[26]  P. Neufer,et al.  Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies , 2005, European Journal of Applied Physiology.

[27]  A. Steensberg,et al.  Leptin gene expression and systemic levels in healthy men: effect of exercise, carbohydrate, interleukin-6, and epinephrine. , 2005, Journal of applied physiology.

[28]  Bente Klarlund Pedersen,et al.  The anti-inflammatory effect of exercise. , 2005, Journal of applied physiology.

[29]  B. Pedersen,et al.  AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. , 2004, Biochemical and biophysical research communications.

[30]  P. Kern,et al.  Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. , 2004, American journal of physiology. Endocrinology and metabolism.

[31]  G. Bergström,et al.  Reduced exercise endurance in interleukin-6-deficient mice. , 2004, Endocrinology.

[32]  N. Ruderman,et al.  Malonyl-CoA and AMP-activated protein kinase: An expanding partnership , 2003, Molecular and Cellular Biochemistry.

[33]  F. Karpe,et al.  Plasma leptin is influenced by diet composition and exercise , 2003, International Journal of Obesity.

[34]  M. Prentki,et al.  AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. , 2003, Acta physiologica Scandinavica.

[35]  B. Saltin,et al.  Interleukin-6 stimulates lipolysis and fat oxidation in humans. , 2003, The Journal of clinical endocrinology and metabolism.

[36]  Bente Klarlund Pedersen,et al.  Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  D. Giannella‐Neto,et al.  Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome. , 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[38]  B. Saltin,et al.  Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. , 2002, Biochemical and biophysical research communications.

[39]  S. Uchida,et al.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.

[40]  M. Prentki,et al.  Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise* , 2002, The Journal of Biological Chemistry.

[41]  E. Jéquier Leptin Signaling, Adiposity, and Energy Balance , 2002, Annals of the New York Academy of Sciences.

[42]  C. Ohlsson,et al.  Interleukin-6-deficient mice develop mature-onset obesity , 2002, Nature Medicine.

[43]  M. Matsuda,et al.  PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. , 2001, Diabetes.

[44]  P. Neufer,et al.  Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. , 2000, American journal of physiology. Endocrinology and metabolism.

[45]  S. Normand,et al.  Leptin responses to physical inactivity induced by simulated weightlessness. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[46]  J. B. Allred,et al.  Short-term regulation of acetyl CoA carboxylase in tissues of higher animals. , 1996, Progress in lipid research.

[47]  B. Spiegelman,et al.  AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity (*) , 1996, The Journal of Biological Chemistry.

[48]  Philipp E. Scherer,et al.  A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*) , 1995, The Journal of Biological Chemistry.

[49]  E. O’Neill,et al.  T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6 , 1994, The Journal of experimental medicine.

[50]  R. Zinkernagel,et al.  Impaired immune and acute-phase responses in interleukin-6-deficient mice , 1994, Nature.

[51]  B. Spiegelman,et al.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.

[52]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.