Practical theoretic guidance for the design of tumor-targeting agents.

[1]  G. Adams,et al.  Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. , 2011, Cancer research.

[2]  Andreas Plückthun,et al.  Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size. , 2010, Cancer research.

[3]  Michael M. Schmidt,et al.  A modeling analysis of the effects of molecular size and binding affinity on tumor targeting , 2009, Molecular Cancer Therapeutics.

[4]  K Dane Wittrup,et al.  Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. , 2008, Advanced drug delivery reviews.

[5]  D. A. Capretto,et al.  Receptor-binding, biodistribution, and metabolism studies of 64Cu-DOTA-cetuximab, a PET-imaging agent for epidermal growth-factor receptor-positive tumors. , 2008, Cancer biotherapy & radiopharmaceuticals.

[6]  K Dane Wittrup,et al.  Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids. , 2008, Cancer research.

[7]  Michael M. Schmidt,et al.  Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability , 2008, Cancer Immunology, Immunotherapy.

[8]  Ralph Weissleder,et al.  Detection of early prostate cancer using a hepsin-targeted imaging agent. , 2008, Cancer research.

[9]  Robert Langer,et al.  Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers , 2008, Proceedings of the National Academy of Sciences.

[10]  Michael M. Schmidt,et al.  Factors determining antibody distribution in tumors. , 2008, Trends in pharmacological sciences.

[11]  Theresa M. Allen,et al.  Antitumor activity of an epithelial cell adhesion molecule–targeted nanovesicular drug delivery system , 2007, Molecular Cancer Therapeutics.

[12]  Wolfgang A. Weber,et al.  Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging , 2007, Proceedings of the National Academy of Sciences.

[13]  L. Weiner,et al.  Regulation of Antibody-Dependent Cellular Cytotoxicity by IgG Intrinsic and Apparent Affinity for Target Antigen1 , 2007, The Journal of Immunology.

[14]  K. Dane Wittrup,et al.  Theoretic Criteria for Antibody Penetration into Solid Tumors and Micrometastases , 2007, Journal of Nuclear Medicine.

[15]  U. Nielsen,et al.  Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. , 2006, Cancer research.

[16]  J. Carlsson,et al.  Tumor imaging using a picomolar affinity HER2 binding affibody molecule. , 2006, Cancer research.

[17]  M. Dewhirst,et al.  Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. , 2006, Journal of the National Cancer Institute.

[18]  C. Mamot,et al.  Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. , 2005, Cancer research.

[19]  R. Ivkov,et al.  Development of Tumor Targeting Bioprobes (111In-Chimeric L6 Monoclonal Antibody Nanoparticles) for Alternating Magnetic Field Cancer Therapy , 2005, Clinical Cancer Research.

[20]  Thommey P. Thomas,et al.  Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. , 2005, Cancer research.

[21]  A. Tomassetti,et al.  90Y Labeling of monoclonal antibody MOv18 and preclinical validation for radioimmunotherapy of human ovarian carcinomas , 2005, Cancer Immunology, Immunotherapy.

[22]  J. Bart,et al.  Preclinical characterisation of 111In‐DTPA‐trastuzumab , 2004, British journal of pharmacology.

[23]  Samuel Zalipsky,et al.  In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[24]  S. Vallabhajosula,et al.  Radiolabeled monoclonal antibodies specific to the extracellular domain of prostate-specific membrane antigen: preclinical studies in nude mice bearing LNCaP human prostate tumor. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[25]  Christilyn P. Graff,et al.  Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. , 2003, Cancer research.

[26]  Theresa M Allen,et al.  Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. , 2002, Cancer research.

[27]  R. Vile,et al.  Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[28]  T M Allen,et al.  In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma. , 1998, Cancer research.

[29]  J N Weinstein,et al.  Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[30]  R K Jain,et al.  Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. , 1995, Cancer research.

[31]  R. Jain,et al.  Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. , 1994, Cancer research.

[32]  G. Griffiths,et al.  Processing of antibody‐radioisotope conjugates after binding to the surface of tumor cells , 1994, Cancer.

[33]  K. Foon,et al.  Biodistribution, pharmacokinetic, and imaging studies with 186Re-labeled NR-LU-10 whole antibody in LS174T colonic tumor-bearing mice. , 1990, Cancer research.

[34]  K. Fujimori,et al.  Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors. , 1989, Cancer research.

[35]  E. W. Thiele.  Relation between Catalytic Activity and Size of Particle , 1939 .

[36]  O. Boerman,et al.  The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies: An autoradiographic study , 2005, Cancer Immunology, Immunotherapy.