On the role of cell signaling models in cancer research.

The main objective of this review is to emphasize the role and importance of the careful mathematical/computational modeling of signaling networks for the understanding of aberrant signaling in cancer and for the development of targeted therapies.

[1]  Harsh V Jain,et al.  Modeling the VEGF–Bcl-2–CXCL8 Pathway in Intratumoral Agiogenesis , 2008, Bulletin of mathematical biology.

[2]  J. Tyson,et al.  Modeling the septation initiation network (SIN) in fission yeast cells , 2007, Current Genetics.

[3]  D. Lauffenburger,et al.  Bioengineering models of cell signaling. , 2000, Annual review of biomedical engineering.

[4]  Reinhart Heinrich,et al.  Mathematical models of protein kinase signal transduction. , 2002, Molecular cell.

[5]  Annie Z. Tremp Malaria: Plasmodium develops in lymph nodes , 2006, Nature Reviews Microbiology.

[6]  A Goldbeter,et al.  A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[7]  James E. Ferrell,et al.  Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible. , 2001, Chaos.

[8]  F. Bruggeman,et al.  Cancer: a Systems Biology disease. , 2006, Bio Systems.

[9]  U. Bhalla,et al.  Complexity in biological signaling systems. , 1999, Science.

[10]  Alejandra C. Ventura,et al.  A Hidden Feedback in Signaling Cascades Is Revealed , 2008, PLoS Comput. Biol..

[11]  D. Lauffenburger,et al.  Physicochemical modelling of cell signalling pathways , 2006, Nature Cell Biology.

[12]  B. Kholodenko Cell-signalling dynamics in time and space , 2006, Nature Reviews Molecular Cell Biology.

[13]  Eduardo Sontag,et al.  Modular cell biology: retroactivity and insulation , 2008, Molecular systems biology.

[14]  D. Koshland,et al.  An amplified sensitivity arising from covalent modification in biological systems. , 1981, Proceedings of the National Academy of Sciences of the United States of America.