Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene

Expression levels of SF2/ASF are controlled by Sam68 mediated activation of splicing-induced mRNA decay.

[1]  A. Krainer,et al.  SF2/ASF Autoregulation Involves Multiple Layers of Post-transcriptional and Translational Control , 2010, Nature Structural &Molecular Biology.

[2]  T. Hyslop,et al.  Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. , 2010, Cancer research.

[3]  D. Elliott,et al.  The Germ Cell Nuclear Proteins hnRNP G-T and RBMY Activate a Testis-Specific Exon , 2009, PLoS genetics.

[4]  Alexander Pertsemlidis,et al.  Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. , 2009, Genes & development.

[5]  R. Weinberg,et al.  Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits , 2009, Nature Reviews Cancer.

[6]  M. Heiner,et al.  Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing , 2009, Molecular and Cellular Biology.

[7]  C. Ghigna,et al.  Alternative Splicing and Tumor Progression , 2008, Current genomics.

[8]  B. Frey,et al.  Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing , 2008, Nature Genetics.

[9]  M. Ares,et al.  Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis , 2008, Molecular and Cellular Biology.

[10]  Eric T. Wang,et al.  Alternative Isoform Regulation in Human Tissue Transcriptomes , 2008, Nature.

[11]  L. Maquat,et al.  The multiple lives of NMD factors: balancing roles in gene and genome regulation , 2008, Nature Reviews Genetics.

[12]  M. Blumenberg,et al.  Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes , 2008, Journal of cellular physiology.

[13]  C. Robson,et al.  The RNA‐binding and adaptor protein Sam68 modulates signal‐dependent splicing and transcriptional activity of the androgen receptor , 2008, The Journal of pathology.

[14]  B. Blencowe,et al.  Regulation of Multiple Core Spliceosomal Proteins by Alternative Splicing-Coupled Nonsense-Mediated mRNA Decay , 2008, Molecular and Cellular Biology.

[15]  K. Lukong,et al.  Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis , 2008, Oncogene.

[16]  C. Smith,et al.  Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1 , 2007, Molecular cell.

[17]  C. Sette,et al.  The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells , 2007, Oncogene.

[18]  O. Rath,et al.  MAP kinase signalling pathways in cancer , 2007, Oncogene.

[19]  S. Brenner,et al.  Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements , 2007, Nature.

[20]  C. Chalfant,et al.  The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x , 2007, The Journal of cell biology.

[21]  Tyson A. Clark,et al.  Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. , 2007, Genes & development.

[22]  A. Krainer,et al.  The gene encoding the splicing factor SF2/ASF is a proto-oncogene , 2007, Nature Structural &Molecular Biology.

[23]  J. Thiery,et al.  Complex networks orchestrate epithelial–mesenchymal transitions , 2006, Nature Reviews Molecular Cell Biology.

[24]  Phillip A. Sharp,et al.  Regulation of CD44 Alternative Splicing by SRm160 and Its Potential Role in Tumor Cell Invasion , 2006, Molecular and Cellular Biology.

[25]  Michael R Green,et al.  Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. , 2005, Molecular cell.

[26]  K. Lukong,et al.  Tyrosine Phosphorylation of Sam68 by Breast Tumor Kinase Regulates Intranuclear Localization and Cell Cycle Progression* , 2005, Journal of Biological Chemistry.

[27]  Jing-Yuan Fang,et al.  The MAPK signalling pathways and colorectal cancer. , 2005, The Lancet. Oncology.

[28]  A. Kornblihtt,et al.  Mammary Epithelial-Mesenchymal Interaction Regulates Fibronectin Alternative Splicing via Phosphatidylinositol 3-Kinase* , 2004, Journal of Biological Chemistry.

[29]  I. Babic,et al.  The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity , 2004, Oncogene.

[30]  C. Sette,et al.  Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer. , 2004, The American journal of pathology.

[31]  J. Shannon,et al.  Epithelial-mesenchymal interactions in the developing lung. , 2004, Annual review of physiology.

[32]  D. Baralle,et al.  hnRNP H binding at the 5' splice site correlates with the pathological effect of two intronic mutations in the NF-1 and TSHbeta genes. , 2004, Nucleic acids research.

[33]  S. Brenner,et al.  An unappreciated role for RNA surveillance , 2004, Genome Biology.

[34]  K. Lukong,et al.  Sam68, the KH domain-containing superSTAR. , 2003, Biochimica et biophysica acta.

[35]  Jean Paul Thiery,et al.  Epithelial-mesenchymal transitions in development and pathologies. , 2003, Current opinion in cell biology.

[36]  P. Herrlich,et al.  Signal-dependent regulation of splicing via phosphorylation of Sam68 , 2002, Nature.

[37]  L. Trusolino,et al.  Scatter-factor and semaphorin receptors: cell signalling for invasive growth , 2002, Nature Reviews Cancer.

[38]  S. Niranjanakumari,et al.  Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo. , 2002, Methods.

[39]  R. Knuechel,et al.  Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[40]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[41]  G. Biamonti,et al.  The replication factory targeting sequence/PCNA‐binding site is required in G1 to control the phosphorylation status of DNA ligase I , 1999, The EMBO journal.