Effect of moderate doses of estrogen and progesterone on mammary growth and hair growth in dogs

An investigation was undertaken to reexamine the nature and extent of the mammary response of gonadectomized dogs to estrogen and to determine the effect of progesterone both alone and in combination with estrogen. 1 male and 7 female dogs were gondectomized. Depending on the extent of mammary development the females were held for different periods of time before treatment to permit mammary involution. Because of the inhibitory effect of estrogen on hair growth in dogs an attempt was made to measure the rate of hair growth and determine the effect of the different treatments thereon. In ovariectomized dogs estrogen in moderate doses caused little or no growth on the mammary gland. Dogs given estrogen and progesterone simultaneously showed extensive growth of the mammary gland the rate and extent of which closely approached that of pregnancy in some cases. Progesterone alone was responsible for a similar type of alveolar development but to a lesser and more variable extent. The rate of hair growth was not significantly influenced by 10 mc estrogen or 10 mg progesterone alone or in combination.

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