Ginsenoside Rb1 attenuates lipopolysaccharide-induced chronic neuroinflammation in mice by tuning glial cell polarization

[1]  W. Le,et al.  Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases , 2015, Molecular Neurobiology.

[2]  L. Cui,et al.  Ginsenoside Rb1 Promotes Motor Functional Recovery and Axonal Regeneration in Post-stroke Mice through cAMP/PKA/CREB Signaling Pathway , 2019, Brain Research Bulletin.

[3]  Jeong-Ho Song,et al.  Inhibitory Effects of Ginsenoside Rb1 on Neuroinflammation Following Systemic Lipopolysaccharide Treatment in Mice , 2013, Phytotherapy research : PTR.

[4]  Muskan Gupta,et al.  Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation , 2019, BMC Complementary and Alternative Medicine.

[5]  Hongyang Lu,et al.  The Role and Mechanism of Borneol to Open the Blood-Brain Barrier , 2018, Integrative cancer therapies.

[6]  K. Suk,et al.  Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation , 2018, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[7]  Manoj Kumar,et al.  INGE GRUNDKE-IQBAL AWARD FOR ALZHEIMER’S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA , 2019, Alzheimer's & Dementia.

[8]  E. Hirsch,et al.  Neuroinflammation in Parkinson's disease: a target for neuroprotection? , 2009, The Lancet Neurology.

[9]  M. Merad,et al.  Regulation of microglia development and homeostasis , 2013, Glia.

[10]  M. Marzorati,et al.  A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action , 2021, European Journal of Nutrition.

[11]  C. Marchand-Leroux,et al.  Behavioral tests that reveal long-term deficits after permanent focal cerebral ischemia in mouse , 2019, Behavioural Brain Research.

[12]  Min Wang,et al.  Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice , 2019, Journal of Neuroimmunology.

[13]  D. McGavern,et al.  Inflammatory neuroprotection following traumatic brain injury , 2016, Science.

[14]  B. Fiebich,et al.  Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration , 2019, International journal of molecular sciences.

[15]  Lloyd H. Michael,et al.  The Guide for the Care and Use of Laboratory Animals. , 2016, ILAR journal.

[16]  A. Cressant,et al.  Neuroinflammation and depression: A review , 2020, The European journal of neuroscience.

[17]  M. Ghasemi-Kasman,et al.  A Review of Herbal Therapy in Multiple Sclerosis , 2018, Advanced pharmaceutical bulletin.

[18]  Y. Liu,et al.  Ginsenoside Rb1 attenuates lipopolysaccharide-induced neural damage in the brain of mice via regulating the dysfunction of microglia and astrocytes. , 2021, Journal of integrative neuroscience.

[19]  J. O'Callaghan,et al.  A Logic Model of Neuronal-Glial Interaction Suggests Altered Homeostatic Regulation in the Perpetuation of Neuroinflammation , 2018, Front. Cell. Neurosci..

[20]  B. Engelhardt,et al.  DARC shuttles inflammatory chemokines across the blood–brain barrier during autoimmune central nervous system inflammation , 2014, Brain : a journal of neurology.

[21]  W. Setzer,et al.  Ginsenoside Rb1 as a neuroprotective agent: A review , 2016, Brain Research Bulletin.

[22]  Zubair Ahmed Ratan,et al.  Pharmacological potential of ginseng and its major component ginsenosides , 2020, Journal of ginseng research.

[23]  P. Edison,et al.  Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? , 2020, Nature Reviews Neurology.

[24]  Li Xiang-gao Studies on pharmacological activity of Gisenoside-Rb_(1) , 2004 .

[25]  A. Molofsky,et al.  Astrocyte development: A Guide for the Perplexed , 2015, Glia.

[26]  G. Martino,et al.  Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy , 2021, Frontiers in Neuroscience.

[27]  W. Banks,et al.  Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. , 2006, Diabetes.

[28]  M. Zhang,et al.  The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod, and Beam Walking , 2009 .

[29]  J. Prickaerts,et al.  Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue , 2021, Biomedicines.

[30]  B. Barres,et al.  Reactive Astrocytes: Production, Function, and Therapeutic Potential. , 2017, Immunity.

[31]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.