Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data

[1]  M. Kayser,et al.  The Use of Forensic DNA Phenotyping in Predicting Appearance and Biogeographic Ancestry. , 2019, Deutsches Arzteblatt international.

[2]  R. Płoski,et al.  DNA-based predictive models for the presence of freckles. , 2019, Forensic science international. Genetics.

[3]  Michael A. Kovacs,et al.  Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations , 2019, BMC Genetics.

[4]  E. Feldman,et al.  Diabetic neuropathy. , 2019, Nature reviews. Disease primers.

[5]  C. Michiels,et al.  TMEM Proteins in Cancer: A Review , 2018, Front. Pharmacol..

[6]  K. Rawlik,et al.  Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability , 2018, Nature Communications.

[7]  Laurent Gil,et al.  Ensembl variation resources , 2018, Database J. Biol. Databases Curation.

[8]  Sarah E. Medland,et al.  Towards broadening Forensic DNA Phenotyping beyond pigmentation: Improving the prediction of head hair shape from DNA. , 2018, Forensic science international. Genetics.

[9]  R. Marioni,et al.  Genotype effects contribute to variation in longitudinal methylome patterns in older people , 2018, Genome Medicine.

[10]  G. de los Campos,et al.  Complex-Trait Prediction in the Era of Big Data. , 2018, Trends in genetics : TIG.

[11]  S. Rosset,et al.  Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics. , 2018, American journal of human genetics.

[12]  Titia Sijen,et al.  The HIrisPlex-S system for eye, hair and skin colour prediction from DNA: Introduction and forensic developmental validation. , 2018, Forensic science international. Genetics.

[13]  Ji Yeon Lee,et al.  Three Streams for the Mechanism of Hair Graying , 2018, Annals of dermatology.

[14]  Sae Rom Hong,et al.  Variation in the RPTN gene may facilitate straight hair formation in Europeans and East Asians. , 2018, Journal of dermatological science.

[15]  A. Uitterlinden,et al.  Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure , 2018, Nature Communications.

[16]  W. Pavan,et al.  A direct link between MITF, innate immunity, and hair graying , 2018, PLoS biology.

[17]  M. P. Concas,et al.  Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability , 2018, Nature Genetics.

[18]  M. Ibáñez,et al.  Genetic determinants of freckle occurrence in the Spanish population: Towards ephelides prediction from human DNA samples. , 2018, Forensic science international. Genetics.

[19]  M. Levine,et al.  GWAS of epigenetic aging rates in blood reveals a critical role for TERT , 2018, Nature Communications.

[20]  A. Uitterlinden,et al.  Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair , 2017, Human molecular genetics.

[21]  P. Kraft,et al.  GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk , 2017, Nature Communications.

[22]  E. Parra,et al.  Genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry , 2017, PeerJ.

[23]  Elizabeth G. Atkinson,et al.  An Unexpectedly Complex Architecture for Skin Pigmentation in Africans , 2017, Cell.

[24]  G. de los Campos,et al.  Will Big Data Close the Missing Heritability Gap? , 2017, Genetics.

[25]  T. Spector,et al.  Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging. , 2017, The Journal of investigative dermatology.

[26]  R. Paus,et al.  Oxidative stress management in the hair follicle: Could targeting NRF2 counter age‐related hair disorders and beyond? , 2017, BioEssays : news and reviews in molecular, cellular and developmental biology.

[27]  A. Wollstein,et al.  Global skin colour prediction from DNA , 2017, Human Genetics.

[28]  T. Spector,et al.  Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness , 2017, Nature Communications.

[29]  M. Simpson,et al.  Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23. , 2017, American journal of human genetics.

[30]  J. Miranda,et al.  Hair follicle characteristics as early marker of Type 2 Diabetes. , 2016, Medical hypotheses.

[31]  Stuart J. Ritchie,et al.  Genetic prediction of male pattern baldness , 2016, bioRxiv.

[32]  Pardis C Sabeti,et al.  Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations , 2016, Human Genetics.

[33]  W. Branicki,et al.  Further evidence for population specific differences in the effect of DNA markers and gender on eye colour prediction in forensics , 2016, International Journal of Legal Medicine.

[34]  D. Balding,et al.  A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features , 2016, Nature Communications.

[35]  A. Hofman,et al.  Prediction of male-pattern baldness from genotypes , 2015, European Journal of Human Genetics.

[36]  K. Christensen,et al.  Mortality is Written on the Face. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[37]  Malgorzata Bogdan,et al.  Phenotypes and Genotypes , 2016, Computational Biology.

[38]  Á. Carracedo,et al.  Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans. , 2015, Forensic science international. Genetics.

[39]  Manfred Kayser,et al.  Forensic DNA Phenotyping: Predicting human appearance from crime scene material for investigative purposes. , 2015, Forensic science international. Genetics.

[40]  Marko Hočevar,et al.  Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma , 2015, Nature Genetics.

[41]  G. Willemsen,et al.  Heritability and Genome-Wide Association Studies for Hair Color in a Dutch Twin Family Based Sample , 2015, Genes.

[42]  Á. Carracedo,et al.  Exploration of SNP variants affecting hair colour prediction in Europeans , 2015, International Journal of Legal Medicine.

[43]  Albert Hofman,et al.  A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots. , 2015, The Journal of investigative dermatology.

[44]  L. Prokunina-Olsson,et al.  Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness , 2015, PloS one.

[45]  Nicholas G. Martin,et al.  Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up , 2015, Human Genetics.

[46]  Hyoseung Shin,et al.  Association of premature hair graying with family history, smoking, and obesity: a cross-sectional study. , 2015, Journal of the American Academy of Dermatology.

[47]  M. Ritchie Finding the epistasis needles in the genome-wide haystack. , 2015, Methods in molecular biology.

[48]  Á. Carracedo,et al.  The genetics of skin, hair, and eye color variation and its relevance to forensic pigmentation predictive tests. , 2015, Forensic science review.

[49]  Peter Claes,et al.  Toward DNA-based facial composites: preliminary results and validation. , 2014, Forensic science international. Genetics.

[50]  M. Kayser,et al.  Human skin color is influenced by an intergenic DNA polymorphism regulating transcription of the nearby BNC2 pigmentation gene. , 2014, Human molecular genetics.

[51]  L. Shapiro,et al.  FGF5 is a crucial regulator of hair length in humans , 2014, Proceedings of the National Academy of Sciences.

[52]  M. Kayser,et al.  The common occurrence of epistasis in the determination of human pigmentation and its impact on DNA-based pigmentation phenotype prediction. , 2014, Forensic science international. Genetics.

[53]  Cesare Furlanello,et al.  A promoter-level mammalian expression atlas , 2015 .

[54]  T. Meehan,et al.  An atlas of active enhancers across human cell types and tissues , 2014, Nature.

[55]  Jeffrey E. Lee,et al.  Joint Effect of Multiple Common SNPs Predicts Melanoma Susceptibility , 2013, PloS one.

[56]  M. Seiberg Age‐induced hair greying – the multiple effects of oxidative stress , 2013, International journal of cosmetic science.

[57]  Theresa Guo,et al.  A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway , 2013, Cell.

[58]  G. Artioli,et al.  Correction: Leucine and HMB Differentially Modulate Proteasome System in Skeletal Muscle under Different Sarcopenic Conditions , 2013, PLoS ONE.

[59]  S. Horvath DNA methylation age of human tissues and cell types , 2013, Genome Biology.

[60]  P Hysi,et al.  Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data , 2013, Journal of data mining in genomics & proteomics.

[61]  Bozena Kaminska,et al.  Nencki Genomics Database—Ensembl funcgen enhanced with intersections, user data and genome-wide TFBS motifs , 2013, Database J. Biol. Databases Curation.

[62]  Benjamin Haibe-Kains,et al.  mRMRe: an R package for parallelized mRMR ensemble feature selection , 2013, Bioinform..

[63]  Jeffrey E. Lee,et al.  Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. , 2013, Human molecular genetics.

[64]  J. Allwood,et al.  SNP model development for the prediction of eye colour in New Zealand. , 2013, Forensic science international. Genetics.

[65]  Pardis C Sabeti,et al.  The adaptive variant EDARV370A is associated with straight hair in East Asians , 2013, Human Genetics.

[66]  Ramiro D. Almeida,et al.  Diabetes Alters KIF1A and KIF5B Motor Proteins in the Hippocampus , 2013, PloS one.

[67]  N. Eriksson,et al.  Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology. , 2013, The Journal of investigative dermatology.

[68]  Mechthild Prinz,et al.  Improved eye- and skin-color prediction based on 8 SNPs , 2013, Croatian medical journal.

[69]  Nicholas A. Johnson,et al.  Genetic Architecture of Skin and Eye Color in an African-European Admixed Population , 2013, PLoS genetics.

[70]  T. Ideker,et al.  Genome-wide methylation profiles reveal quantitative views of human aging rates. , 2013, Molecular cell.

[71]  M V Lareu,et al.  Further development of forensic eye color predictive tests. , 2013, Forensic science international. Genetics.

[72]  Albert Hofman,et al.  Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans , 2012, Human Genetics.

[73]  G. Loussouarn,et al.  Greying of the human hair: a worldwide survey, revisiting the ‘50’ rule of thumb , 2012, The British journal of dermatology.

[74]  Masaaki Ito,et al.  A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis. , 2012, The Journal of investigative dermatology.

[75]  M. Çetin,et al.  The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age. , 2012, Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.

[76]  T. Kupiec,et al.  Prediction of Eye Color from Genetic Data Using Bayesian Approach * , 2012, Journal of forensic sciences.

[77]  N. Eriksson,et al.  Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases , 2012, PLoS genetics.

[78]  Y. Lee,et al.  Hair greying is associated with active hair growth , 2011, The British journal of dermatology.

[79]  R Erbel,et al.  Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male‐pattern baldness , 2011, The British journal of dermatology.

[80]  C. Tyler-Smith,et al.  Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing , 2011, Investigative Genetics.

[81]  T. Kodama,et al.  Suppression of bone formation by osteoclastic expression of semaphorin 4D , 2011, Nature Medicine.

[82]  A. Mes-Masson,et al.  KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2. , 2011, American journal of human genetics.

[83]  A. McRae,et al.  GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development. , 2011, American journal of human genetics.

[84]  Anna Wojas-Pelc,et al.  Gene–gene interactions contribute to eye colour variation in humans , 2011, Journal of Human Genetics.

[85]  Yaniv Erlich,et al.  Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. , 2011, Genome research.

[86]  M. DePristo,et al.  A framework for variation discovery and genotyping using next-generation DNA sequencing data , 2011, Nature Genetics.

[87]  Anna Wojas-Pelc,et al.  Model-based prediction of human hair color using DNA variants , 2011, Human Genetics.

[88]  S. Harrap,et al.  Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene , 2010, Experimental dermatology.

[89]  Niels Morling,et al.  Human eye colour and HERC2, OCA2 and MATP. , 2010, Forensic science international. Genetics.

[90]  M. DePristo,et al.  The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. , 2010, Genome research.

[91]  R. Freeman,et al.  Diabetic Neuropathy , 2010, Diabetes Care.

[92]  A. Yashin,et al.  Joint influence of small-effect genetic variants on human longevity , 2010, Aging.

[93]  Brian T. Naughton,et al.  Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits , 2010, PLoS genetics.

[94]  Nicholas G. Martin,et al.  Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci , 2010, PLoS genetics.

[95]  A. Christiano,et al.  Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture. , 2010, American journal of human genetics.

[96]  M. Goossens,et al.  Review and update of mutations causing Waardenburg syndrome , 2010, Human mutation.

[97]  Shosuke Ito,et al.  Predicting Phenotype from Genotype: Normal Pigmentation * , 2010, Journal of forensic sciences.

[98]  E. Parra,et al.  Association of the OCA2 Polymorphism His615Arg with Melanin Content in East Asian Populations: Further Evidence of Convergent Evolution of Skin Pigmentation , 2010, PLoS genetics.

[99]  M. Nöthen,et al.  Fine mapping of the human AR/EDA2R locus in androgenetic alopecia , 2009, The British journal of dermatology.

[100]  Niels Morling,et al.  Genetic determinants of hair and eye colours in the Scottish and Danish populations , 2009, BMC Genetics.

[101]  Kaare Christensen,et al.  Perceived age as clinically useful biomarker of ageing: cohort study , 2009, BMJ : British Medical Journal.

[102]  Michael Catt,et al.  Why Some Women Look Young for Their Age , 2009, PloS one.

[103]  Manuel A. R. Ferreira,et al.  Common variants in the trichohyalin gene are associated with straight hair in Europeans. , 2009, American journal of human genetics.

[104]  Peter Kraft,et al.  Genome-wide association study of tanning phenotype in a population of European ancestry. , 2009, The Journal of investigative dermatology.

[105]  T. Tsunoda,et al.  FGFR2 is associated with hair thickness in Asian populations , 2009, Journal of Human Genetics.

[106]  J. Malvehy,et al.  Genome-wide association study identifies three loci associated with melanoma risk , 2009, Nature Genetics.

[107]  M. Nöthen,et al.  Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness , 2009, Human Genetics.

[108]  A. Cecile J.W. Janssens,et al.  Eye color and the prediction of complex phenotypes from genotypes , 2009, Current Biology.

[109]  L. Shapiro,et al.  Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis. , 2009, The Journal of investigative dermatology.

[110]  Jean Krutmann,et al.  The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing. , 2009, Journal of dermatological science.

[111]  Cole Trapnell,et al.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.

[112]  D. Araújo-Vilar,et al.  Prematurely aged children: molecular alterations leading to Hutchinson-Gilford progeria and Werner syndromes. , 2008, Current aging science.

[113]  T. Spector,et al.  Male-pattern baldness susceptibility locus at 20p11 , 2008, Nature Genetics.

[114]  Thomas W. Mühleisen,et al.  Susceptibility variants for male-pattern baldness on chromosome 20p11 , 2008, Nature Genetics.

[115]  T. Kupiec,et al.  Association of the SLC45A2 gene with physiological human hair colour variation , 2008, Journal of Human Genetics.

[116]  Andrea Picciau,et al.  EDA2R is associated with androgenetic alopecia. , 2008, The Journal of investigative dermatology.

[117]  Snæbjörn Pálsson,et al.  Two newly identified genetic determinants of pigmentation in Europeans , 2008, Nature Genetics.

[118]  C. Hoggart,et al.  Simultaneous Analysis of All SNPs in Genome-Wide and Re-Sequencing Association Studies , 2008, PLoS genetics.

[119]  F. Hu,et al.  A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation , 2008, PLoS genetics.

[120]  Katsushi Tokunaga,et al.  A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness. , 2008, Human molecular genetics.

[121]  D. Gordon,et al.  Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair , 2008, Nature Genetics.

[122]  Johan T den Dunnen,et al.  Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. , 2008, American journal of human genetics.

[123]  Nicholas G Martin,et al.  A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color. , 2008, American journal of human genetics.

[124]  Hans Eiberg,et al.  Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression , 2008, Human Genetics.

[125]  D. Cox,et al.  A genomewide association study of skin pigmentation in a South Asian population. , 2007, American journal of human genetics.

[126]  Snæbjörn Pálsson,et al.  Genetic determinants of hair, eye and skin pigmentation in Europeans , 2007, Nature Genetics.

[127]  Simon Günter,et al.  Stratification bias in low signal microarray studies , 2007, BMC Bioinformatics.

[128]  T. Kupiec,et al.  Determination of Phenotype Associated SNPs in the MC1R Gene * , 2007, Journal of forensic sciences.

[129]  Justin Graf,et al.  Promoter polymorphisms in the MATP (SLC45A2) gene are associated with normal human skin color variation , 2007, Human mutation.

[130]  Wei Chen,et al.  A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation. , 2007, American journal of human genetics.

[131]  B. Klapp,et al.  Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[132]  D. Fisher,et al.  Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche , 2005, Science.

[133]  D. Tobin,et al.  Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging. , 2004, Micron.

[134]  S. Blumen,et al.  A locus for complicated hereditary spastic paraplegia maps to chromosome 1q24‐q32 , 2003, Annals of neurology.

[135]  E. Medrano,et al.  The emerging role of epigenetics in cellular and organismal aging , 2003, Experimental Gerontology.

[136]  Chris H. Q. Ding,et al.  Minimum redundancy feature selection from microarray gene expression data , 2003, Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003.

[137]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[138]  Kenji Kohno,et al.  Identification of a Novel Non-structural Maintenance of Chromosomes (SMC) Component of the SMC5-SMC6 Complex Involved in DNA Repair* , 2002, The Journal of Biological Chemistry.

[139]  Sridhar Ramaswamy,et al.  Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability , 2002, Cell.

[140]  D. Tobin,et al.  Graying: gerontobiology of the hair follicle pigmentary unit , 2001, Experimental Gerontology.

[141]  I. Reid,et al.  Premature hair graying and bone mineral density. , 1997, The Journal of clinical endocrinology and metabolism.

[142]  P. Schnohr,et al.  Gray hair, baldness, and wrinkles in relation to myocardial infarction: the Copenhagen City Heart Study. , 1995, American heart journal.

[143]  R. Dawber INTEGUMENTARY ASSOCIATIONS OF PERNICIOUS ANAEMIA , 1970, The British journal of dermatology.

[144]  E. Keogh,et al.  Rate of Greying of Human Hair , 1965, Nature.