Epizootic outbreaks of gizzard erosion associated with adenovirus infection in chickens.

Two outbreaks of gizzard erosion in slaughtered broiler chickens in Japan were examined pathologically and microbiologically. The prevalences of such lesions were 9%-11% and 4%-50% in the affected flocks. Affected chickens had no clinical signs. Group I fowl adenovirus (FAV) serotype 1 was isolated from gizzard lesions. Histologically, gizzard mucosa were necrotic. Intranuclear inclusion bodies were seen in the enlarged nuclei of degenerating epithelial cells of the gizzard. The keratinoid layer in the erosion was edematous and desquamated and contained degenerative cells. Moderate to marked inflammatory cell infiltration was observed in the lamina propria and perivascular connective tissue in the submucosa and muscle layer. Immunohistochemical staining showed evidence of FAV antigens in the intranuclear inclusion bodies within degenerating epithelial cells. Ultrastructurally, numerous viral particles were demonstrated in the inclusions.

[1]  S. Sato,et al.  Experimental infection of specific-pathogen-free chickens with serotype-1 fowl adenovirus isolated from a broiler chicken with gizzard erosions. , 2001, Avian diseases.

[2]  M. Hess,et al.  Hexon based PCRs combined with restriction enzyme analysis for rapid detection and differentiation of fowl adenoviruses and egg drop syndrome virus. , 1998, Journal of virological methods.

[3]  F. Hoerr,et al.  Gastrointestinal Pathogenicity of Adenoviruses and Reoviruses Isolated from Broiler Chickens in Alabama , 1998, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[4]  M. Goodwin.  Adenovirus inclusion body ventriculitis in chickens and captive bobwhite quail (Colinus virginianus). , 1993, Avian diseases.

[5]  K. Nakamura,et al.  Necrotizing pancreatitis and gizzard erosion associated with adenovirus infection in chickens. , 1993, Avian diseases.

[6]  C. Wilks,et al.  Effects of fowl adenovirus infection on the immune system of chickens. , 1992, Journal of comparative pathology.

[7]  D. Barr,et al.  Molecular characterization of highly virulent fowl adenoviruses associated with outbreaks of inclusion body hepatitis. , 1991, Avian pathology : journal of the W.V.P.A.

[8]  O. Fossum,et al.  Gizzard erosions as a cause of mortality in White Leghorn chickens. , 1988, Avian pathology : journal of the W.V.P.A.

[9]  K. Mori,et al.  Gizzerosine, a New Toxic Substance in Fish Meal, Causes Severe Gizzard Erosion in Chicks , 1983 .

[10]  N. Daghir,et al.  Vitamin B6 in the etiology of gizzard erosion in growing chickens. , 1981, Poultry science.

[11]  J. Giambrone,et al.  Effect of tenuazonic acid on young chickens. , 1978, Poultry science.

[12]  McFerran Jb,et al.  Further studies on the classification of fowl adenoviruses. , 1977 .

[13]  King Dj,et al.  Effect of maternal antibody on experimental infections of chickens with a type-8 avian adenovirus. , 1977 .

[14]  E. Harry,et al.  The effect of orally administered histamine on the weight gain and development of gizzard lesions in chicks , 1976, Veterinary Record.

[15]  A. Fadly,et al.  Role of the bursa of Fabricius in the pathogenicity of inclusion body hepatitis and infectious bursal disease viruses. , 1976, Avian diseases.