[A case of Klinefelter syndrome associated with lung cancer and RA lung].

A 50-year-old man was admitted for evaluation of an abnormal shadow on a chest X-ray. He had experienced pain and swelling in his fingers for three years. He had also noticed that he is impotent. The diagnosis of Klinefelter syndrome and rheumatoid arthritis (RA) was established by clinical findings and chromosomal analysis. Transbronchial biopsy revealed adenocarcinoma and right upper lobectomy was performed. Open lung biopsy showed interstitial pneumonia. In conclusion, we reported a rare case of lung cancer, rheumatoid arthritis and RA lung associated with Klinefelter syndrome.

[1]  C. Logothetis,et al.  Genetic abnormalities in men with germ cell tumors. , 1988, The Journal of urology.

[2]  A. K. Sharma,et al.  Extensive Verrucosis, Squamous Cell Carcinoma, and Immunologic Abnormality in Klinefelter's Syndrome , 1986, International journal of dermatology.

[3]  C. Phebus,et al.  Acute megakaryoblastic leukemia and Klinefelter's syndrome. , 1986, The American journal of pediatric hematology/oncology.

[4]  N. Talal,et al.  Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. , 1977, The Journal of clinical investigation.

[5]  N. Maclean,et al.  S.L.E. AND KLINEFELTER'S SYNDROME , 1976, The Lancet.

[6]  Tsung Sh,et al.  Klinefelter syndrome, immunological disorders, and malignant neoplasm: report of a case. , 1974 .

[7]  M. Salmon,et al.  Association of autoimmune disorders and sex-chromosome anomalies. , 1970, Lancet.

[8]  D. Rickards,et al.  Klinefelter's Syndrome and Pulmonary Disease1 , 1968 .

[9]  R. N. Macsween RETICULUM-CELL SARCOMA AND RHEUMATOID ARTHRITIS IN A PATIENT WITH XY/XXY/XXXY KLINEFELTER'S SYNDROME AND NORMAL INTELLIGENCE. , 1965, Lancet.

[10]  C. H. Ockey,et al.  Carcinoma of Male Breast in Association with the Klinefelter Syndrome , 1965, British medical journal.

[11]  D. Green,et al.  Mongolism and thyroid autoantibodies. , 2008, Journal of mental deficiency research.

[12]  F. Albright,et al.  Syndrome Characterized by Gynecomastia, Aspermatogenesis without A-Leydigism, and Increased Excretion of Follicle-Stimulating Hormone1 , 1942 .