Counterpoint: Are Insulin Pumps Underutilized in Type 1 Diabetes? No

One of the major goals in the treatment of diabetes is to achieve an HbA1c (A1C) 200,000 worldwide (3). This article will address one specific question, i.e., whether a major effort should be made to increase the number of patients on insulin pumps in order to achieve the above-stated A1C goal. There are several factors that determine plasma glucose concentration. These include 1 ) the carbohydrate composition of food, 2 ) the rate of gastric emptying, 3 ) the rate of glucose absorption, 4 ) the concurrent magnitude of endogenous glucose production, 5 ) the concurrent rate of glucose disposal, 6 ) the diurnal change in insulin sensitivity, 7 ) the activity of counterregulatory hormones, 8 ) the change in the magnitude and type of exercise, and 9 ) the ambient insulin concentration. It is important to note that most of these factors are not directly under the patient’s control. Many of the factors are interrelated, so that altering one may affect the magnitude of the other. Thus, in attempting to normalize plasma …

[1]  Darrell M. Wilson,et al.  A two-center randomized controlled feasibility trial of insulin pump therapy in young children with diabetes. , 2005, Diabetes care.

[2]  Bonnie Melville The insulin pump: why not use it for every type I diabetic patient? , 2005, Critical care nursing quarterly.

[3]  L. Heinemann,et al.  Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. , 2004, Diabetes.

[4]  P. Brunetti,et al.  Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. , 2000, Diabetes.

[5]  D. Schade,et al.  The dawn phenomenon revisited: implications for diabetes therapy. , 2005, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[6]  C. Binder,et al.  Pharmacokinetics of continuous subcutaneous insulin infusion , 1983, Diabetologia.

[7]  R. Heine,et al.  A randomized trial of continuous subcutaneous insulin infusion and intensive injection therapy in type 1 diabetes for patients with long-standing poor glycemic control. , 2002, Diabetes care.

[8]  R. Mathur,et al.  Similar A1C outcomes in type 1 diabetic patients undergoing intensive diabetes management with preprandial rapid-acting insulin and either CSII or glargine. , 2004, Diabetes care.

[9]  M. Riddle,et al.  Evolving Approaches to Intensive Insulin Therapy in Type 1 Diabetes: Multiple Daily Injections, Insulin Pumps and New Methods of Monitoring , 2003, Reviews in Endocrine & Metabolic Disorders.

[10]  Bruce W Bode,et al.  Diabetes management in the new millennium using insulin pump therapy , 2002, Diabetes/metabolism research and reviews.

[11]  I. Hirsch,et al.  Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review. , 2003, JAMA.

[12]  R. Marfella,et al.  Plasma interleukin-18 concentrations are elevated in type 2 diabetes. , 2004, Diabetes care.

[13]  H. Chase,et al.  Post‐prandial glucose excursions following four methods of bolus insulin administration in subjects with Type 1 diabetes , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[14]  R. Trevisan,et al.  Both continuous subcutaneous insulin infusion and a multiple daily insulin injection regimen with glargine as basal insulin are equally better than traditional multiple daily insulin injection treatment. , 2003, Diabetes care.

[15]  D. Schade,et al.  To pump or not to pump. , 2002, Diabetes care.

[16]  I. Hirsch,et al.  Continuous subcutaneous insulin infusion (CSII) of insulin aspart versus multiple daily injection of insulin aspart/insulin glargine in type 1 diabetic patients previously treated with CSII. , 2005, Diabetes care.

[17]  W. Tamborlane,et al.  A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine. , 2004, Diabetes care.

[18]  John Pickup,et al.  Continuous subcutaneous insulin infusion at 25 years: evidence base for the expanding use of insulin pump therapy in type 1 diabetes. , 2002, Diabetes care.