Structure of the Complement Factor 5a Receptor-Ligand Complex Studied by Disulfide Trapping and Molecular Modeling*
暂无分享,去创建一个
Ian S. Hagemann | Gregory V. Nikiforovich | J. Klco | G. Nikiforovich | T. Baranski | I. Hagemann | Daniel L. Miller | Jeffery M. Klco | Thomas J. Baranski
[1] J. Demartino,et al. Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[2] C. Gerard,et al. The chemotactic receptor for human C5a anaphylatoxin , 1991, Nature.
[3] J. Demartino,et al. The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs. , 1994, The Journal of biological chemistry.
[4] H. Schiöth,et al. The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes , 2005, Molecular Pharmacology.
[5] E. Zuiderweg,et al. Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[6] D. Underwood,et al. Arginine 206 of the C5a Receptor Is Critical for Ligand Recognition and Receptor Activation by C-terminal Hexapeptide Analogs (*) , 1995, The Journal of Biological Chemistry.
[7] F. Boulay,et al. The NH2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding. , 1994, The Journal of biological chemistry.
[8] J. Köhl,et al. Site-Directed Mutagenesis of Conserved Charged Residues in the Helical Region of the Human C5a Receptor , 1996 .
[9] M. Grossmann,et al. G Protein-coupled Receptors , 1998, The Journal of Biological Chemistry.
[10] G. Nikiforovich,et al. A Comprehensive Structure-Function Map of the Intracellular Surface of the Human C5a Receptor , 2007, Journal of Biological Chemistry.
[11] G. Carter,et al. Structure-function studies in a series of carboxyl-terminal octapeptide analogues of anaphylatoxin C5a. , 1992, Journal of medicinal chemistry.
[12] W. Boyar,et al. Solution structure of a unique C5a semi‐synthetic antagonist: Implications in receptor binding , 1997, Protein science : a publication of the Protein Society.
[13] E. Zuiderweg,et al. Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data. , 1989, Biochemistry.
[14] P. Monk,et al. The influence of Lys68 in decepeptide agonists of C5a on C5a receptor binding, activation and selectivity. , 1999, The journal of peptide research : official journal of the American Peptide Society.
[15] F. Boulay,et al. Evidence that the extracellular N‐terminal domain of C5aR contains amino‐acid residues crucial for C5a binding , 1993, European journal of haematology.
[16] R. Stevens,et al. High-Resolution Crystal Structure of an Engineered Human β2-Adrenergic G Protein–Coupled Receptor , 2007, Science.
[17] P. Monk,et al. Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor. , 2001, Biochemistry.
[18] A. Higginbottom,et al. Comparative Agonist/Antagonist Responses in Mutant Human C5a Receptors Define the Ligand Binding Site* , 2005, Journal of Biological Chemistry.
[19] Ian S Hagemann,et al. Random Mutagenesis of the Complement Factor 5a (C5a) Receptor N Terminus Provides a Structural Constraint for C5a Docking* , 2006, Journal of Biological Chemistry.
[20] Elaine C. Meng,et al. An Activation Switch in the Ligand Binding Pocket of the C5a Receptor* , 2001, The Journal of Biological Chemistry.
[21] J. Klco,et al. Essential role for the second extracellular loop in C5a receptor activation , 2005, Nature Structural &Molecular Biology.
[22] J. Klco,et al. Genetic Analysis of the First and Third Extracellular Loops of the C5a Receptor Reveals an Essential WXFG Motif in the First Loop* , 2006, Journal of Biological Chemistry.
[23] J. Bockaert,et al. Molecular tinkering of G protein‐coupled receptors: an evolutionary success , 1999, The EMBO journal.
[24] J. Thorner,et al. Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. , 2001, Annual review of biochemistry.
[25] O. Lichtarge,et al. C5a Receptor Activation , 1999, The Journal of Biological Chemistry.
[26] F. Colotta,et al. Targeting C5a: recent advances in drug discovery. , 2005, Current medicinal chemistry.
[27] J. Köhl,et al. Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor. , 1994, European journal of biochemistry.
[28] A. Finch,et al. Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity. , 1997, Journal of medicinal chemistry.
[29] G. Marshall,et al. Modeling flexible loops in the dark-adapted and activated states of rhodopsin, a prototypical G-protein-coupled receptor. , 2005, Biophysical journal.
[30] Wayne A. Hendrickson,et al. Structure of human follicle-stimulating hormone in complex with its receptor , 2005, Nature.
[31] M. Marzioch,et al. Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein α‐subunit chimeras , 2000, Yeast.
[32] J. Drews. Drug discovery: a historical perspective. , 2000, Science.
[33] W. Boyar,et al. Residues 21–30 within the Extracellular N-terminal Region of the C5a Receptor Represent a Binding Domain for the C5a Anaphylatoxin* , 1998, The Journal of Biological Chemistry.
[34] O. Lichtarge,et al. Genetic Mapping of the Human C5a Receptor , 2000, The Journal of Biological Chemistry.
[35] Garland R Marshall,et al. Three-dimensional model for meta-II rhodopsin, an activated G-protein-coupled receptor. , 2003, Biochemistry.
[36] L. F. Kolakowski,et al. Probing the Message:Address Sites for Chemoattractant Binding to the C5a Receptor , 1995, The Journal of Biological Chemistry.
[37] W. Boyar,et al. The pharmacophore of the human C5a anaphylatoxin , 1994, Protein science : a publication of the Protein Society.