Proteolysis mediated by cysteine cathepsins and legumain—recent advances and cell biological challenges
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[1] S. Macedo-Ribeiro,et al. Molecular and computational analyses of genes involved in mannose 6‐phosphate independent trafficking , 2015, Clinical genetics.
[2] J. Kos,et al. Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer. , 2015, Seminars in cancer biology.
[3] K. Sandvig,et al. LYST Affects Lysosome Size and Quantity, but not Trafficking or Degradation Through Autophagy or Endocytosis , 2014, Traffic.
[4] O. Vasiljeva,et al. A Role for Stefin B (Cystatin B) in Inflammation and Endotoxemia* , 2014, The Journal of Biological Chemistry.
[5] G. Salvesen,et al. Regulated cell death: signaling and mechanisms. , 2014, Annual review of cell and developmental biology.
[6] C. Peters,et al. The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length , 2014, Biological chemistry.
[7] Laura H. Tang,et al. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix , 2014, Genes & development.
[8] K. Eliceiri,et al. SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. , 2014, The Journal of clinical investigation.
[9] T. Reinheckel,et al. Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo , 2014, Nature Communications.
[10] M. Freeman,et al. Sharpening rhomboid specificity by dimerisation and allostery , 2014, The EMBO journal.
[11] J. Luzio,et al. The biogenesis of lysosomes and lysosome-related organelles. , 2014, Cold Spring Harbor perspectives in biology.
[12] James M Wright,et al. Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension. , 2014, The Cochrane database of systematic reviews.
[13] S. Ventura,et al. Human Stefin B Role in Cell's Response to Misfolded Proteins and Autophagy , 2014, PloS one.
[14] W. Hahn,et al. Analysis of tumor- and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S , 2014, Nature Cell Biology.
[15] I. Oglesby,et al. miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. , 2014, American journal of respiratory and critical care medicine.
[16] R. Solberg,et al. Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. , 2014, Bioorganic & medicinal chemistry.
[17] O. Vasiljeva,et al. Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor , 2014, Angewandte Chemie.
[18] O. Vasiljeva,et al. Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model , 2014, Oncogene.
[19] Frances M. Platt,et al. Sphingolipid lysosomal storage disorders , 2014, Nature.
[20] M. Fonović,et al. Cysteine cathepsins and their potential in clinical therapy and biomarker discovery , 2014, Proteomics. Clinical applications.
[21] X. Chen,et al. Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis. , 2014, Journal of the National Cancer Institute.
[22] Ruth Geiss-Friedlander,et al. The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus , 2014, Cellular and Molecular Life Sciences.
[23] J. Schilling,et al. Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation* , 2014, The Journal of Biological Chemistry.
[24] Rama Ranganathan,et al. A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods , 2014, Nature Communications.
[25] F. Levi-Schaffer,et al. Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease* , 2014, The Journal of Biological Chemistry.
[26] G. Cheng,et al. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage , 2014, Cell Research.
[27] C. Peters,et al. The endolysosomal cysteine cathepsins L and K are involved in macrophage‐mediated clearance of Staphylococcus aureus and the concomitant cytokine induction , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[28] Neil D. Rawlings,et al. MEROPS: the database of proteolytic enzymes, their substrates and inhibitors , 2013, Nucleic Acids Res..
[29] J. Gruenberg,et al. ALIX and the multivesicular endosome: ALIX in Wonderland. , 2014, Trends in cell biology.
[30] M. Groll,et al. Applied techniques for mining natural proteasome inhibitors. , 2014, Biochimica et biophysica acta.
[31] H. Plattner,et al. Unicellular eukaryotes as models in cell and molecular biology: critical appraisal of their past and future value. , 2014, International review of cell and molecular biology.
[32] S. Urban,et al. Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity , 2013, Cell.
[33] M. Freeman,et al. Intramembrane proteolysis by rhomboids: catalytic mechanisms and regulatory principles. , 2013, Current opinion in structural biology.
[34] R. Pike,et al. The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates. , 2013, Current opinion in structural biology.
[35] M. J. Lemieux,et al. Untangling structure-function relationships in the rhomboid family of intramembrane proteases. , 2013, Biochimica et biophysica acta.
[36] K. Sandhoff. Metabolic and cellular bases of sphingolipidoses. , 2013, Biochemical Society transactions.
[37] Joseph S. Briguglio,et al. Lysosomal sorting receptors are essential for secretory granule biogenesis in Tetrahymena , 2013, The Journal of cell biology.
[38] Bonnie F. Sloane,et al. Proteases in Cancer: Significance for Invasion and Metastasis , 2013 .
[39] D. Quail,et al. Microenvironmental regulation of tumor progression and metastasis , 2014 .
[40] Paul H. Bessette,et al. Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index , 2013, Science Translational Medicine.
[41] O. Schilling,et al. Proteomic identification of protease cleavage sites: cell-biological and biomedical applications , 2013, Expert review of proteomics.
[42] V. Turk,et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes , 2013, Cell Death and Disease.
[43] Wan-Xi Yang,et al. Modes of acrosin functioning during fertilization. , 2013, Gene.
[44] M. Bogyo,et al. Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses. , 2013, Biochemistry.
[45] Marko Novinec,et al. Cathepsin K: a unique collagenolytic cysteine peptidase , 2013, Biological chemistry.
[46] G. Raposo,et al. Lysosome-related organelles: unusual compartments become mainstream. , 2013, Current opinion in cell biology.
[47] G. Salvesen,et al. Caspase substrates and inhibitors. , 2013, Cold Spring Harbor perspectives in biology.
[48] H. Brandstetter,et al. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation , 2013, Proceedings of the National Academy of Sciences.
[49] T. Reinheckel. On the road to inflammation: Linking lysosome disruption, lysosomal protease release and necrotic death of immune cells , 2013, Cell cycle.
[50] Manuel Serrano,et al. The Hallmarks of Aging , 2013, Cell.
[51] M. Jäättelä,et al. Combating apoptosis and multidrug resistant cancers by targeting lysosomes. , 2013, Cancer letters.
[52] K. Chandran,et al. Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death , 2013, Cell cycle.
[53] M. Jäättelä,et al. Lysosomal cell death at a glance , 2013, Journal of Cell Science.
[54] M. Abrahamson,et al. Cystatin C Properties Crucial for Uptake and Inhibition of Intracellular Target Enzymes* , 2013, The Journal of Biological Chemistry.
[55] G. Blum,et al. Ready, set, cleave: proteases in action. , 2013, Chemistry & biology.
[56] M. Bogyo,et al. Target deconvolution techniques in modern phenotypic profiling. , 2013, Current opinion in chemical biology.
[57] G. Maelandsmo,et al. Nuclear Legumain Activity in Colorectal Cancer , 2013, PloS one.
[58] A. Newland,et al. Brentuximab Vedotin: A CD30‐Directed Antibody‐Cytotoxic Drug Conjugate , 2013, Pharmacotherapy.
[59] C. Isidoro,et al. Cathepsins: Getting in Shape for Lysosomal Proteolysis , 2013 .
[60] K. Brix,et al. Proteases: Structure and Function , 2013, Springer Vienna.
[61] K. Brix,et al. Compartmentalization of Proteolysis , 2013 .
[62] S. Kostrov,et al. Handbook of proteolytic enzymes, 3rd Edition , 2013 .
[63] K. Brix. Lysosomal Proteases: Revival of the Sleeping Beauty , 2013 .
[64] N. Rawlings,et al. Introduction: Aspartic and Glutamic Peptidases and Their Clans , 2013 .
[65] O. Schilling,et al. Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances , 2013 .
[66] C. Peters,et al. Exploring Systemic Functions of Lysosomal Proteases: The Perspective of Genetically Modified Mouse Models , 2013 .
[67] M. Grütter,et al. Proteases in Death Pathways , 2013 .
[68] S. Rose-John,et al. ADAM Proteases in Physiology and Pathophysiology: Cleave to Function in Health or to Cause Disease , 2013 .
[69] Marko Novinec,et al. Kinetics of the Interaction of Peptidases with Substrates and Modifiers , 2013 .
[70] M. Groll,et al. Inhibitors for the Immuno‐ and Constitutive Proteasome: Current and Future Trends in Drug Development , 2012 .
[71] Michael D. Taylor,et al. MicroRNA 218 Acts as a Tumor Suppressor by Targeting Multiple Cancer Phenotype-associated Genes in Medulloblastoma* , 2012, The Journal of Biological Chemistry.
[72] P. Saftig,et al. Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon , 2012, Biological chemistry.
[73] V. Turk,et al. Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines , 2012, Biological chemistry.
[74] Geoffrey I. Webb,et al. PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites , 2012, PloS one.
[75] M. Prata,et al. A shortcut to the lysosome: the mannose-6-phosphate-independent pathway. , 2012, Molecular genetics and metabolism.
[76] M. Seaman. The retromer complex – endosomal protein recycling and beyond , 2012, Journal of Cell Science.
[77] S. Kelm,et al. Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice , 2012, Biological chemistry.
[78] R. Guttmann,et al. Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration , 2012, International journal of cell biology.
[79] C. Chelala,et al. S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells. , 2012, The American journal of pathology.
[80] Bonnie F. Sloane,et al. MAME models for 4D live-cell imaging of tumor: microenvironment interactions that impact malignant progression. , 2012, Journal of visualized experiments : JoVE.
[81] J. Johnston,et al. Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas. , 2012, Biochimie.
[82] Kwangmeyung Kim,et al. Protease Activity: Meeting Its Theranostic Potential , 2012, Theranostics.
[83] T. Reinheckel,et al. Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment , 2012, Journal of Virology.
[84] A. Shen. Clostridium difficile Toxins: Mediators of Inflammation , 2012, Journal of Innate Immunity.
[85] M. Bogyo,et al. New approaches for dissecting protease functions to improve probe development and drug discovery , 2012, Nature Structural &Molecular Biology.
[86] Olga Vasiljeva,et al. Cysteine cathepsins: From structure, function and regulation to new frontiers , 2011, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.
[87] H. Brandstetter,et al. Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile. , 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.
[88] V. Turk. Special issue: Proteolysis 50 years after the discovery of lysosome in honor of Christian de Duve. , 2012, Biochimica et biophysica acta.
[89] C. Liu,et al. Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug. , 2012, Molecular pharmaceutics.
[90] M. Kindy,et al. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. , 2012, Biochimica et biophysica acta.
[91] V. Turk,et al. Lysosomes and lysosomal cathepsins in cell death. , 2012, Biochimica et biophysica acta.
[92] Bonnie F. Sloane,et al. 3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment. , 2012, Methods in enzymology.
[93] M. Bogyo,et al. Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. , 2011, Current opinion in chemical biology.
[94] S. Urban,et al. The rhomboid protease family: a decade of progress on function and mechanism , 2011, Genome Biology.
[95] O. Schilling,et al. Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. , 2011, Journal of proteome research.
[96] J. M. Ortega,et al. Nucleoplasmic calcium regulates cell proliferation through legumain. , 2011, Journal of hepatology.
[97] P. Seglen,et al. Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain , 2011, Autophagy.
[98] Christoph Peters,et al. Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. , 2011, Nature nanotechnology.
[99] C. Overall,et al. TopFIND, a knowledgebase linking protein termini with function , 2011, Nature Methods.
[100] M. Bogyo,et al. Cathepsin B trafficking in thyroid carcinoma cells , 2011, Thyroid research.
[101] P. Saftig,et al. Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits , 2011, BMC Neuroscience.
[102] Constance J Jeffery,et al. Proteins with neomorphic moonlighting functions in disease , 2011, IUBMB life.
[103] D. Führer,et al. Thyroid Cathepsin K: Roles in Physiology and Thyroid Disease , 2011 .
[104] Harald Steiner,et al. Regulated intramembrane proteolysis – lessons from amyloid precursor protein processing , 2011, Journal of neurochemistry.
[105] R. A. Mir,et al. Post-transcriptional regulation of human cathepsin L expression , 2011, Biological chemistry.
[106] J. Joyce,et al. Proteolytic networks in cancer. , 2011, Trends in cell biology.
[107] G. Arancia,et al. Autophagy: Molecular mechanisms and their implications for anticancer therapies. , 2011, Current cancer drug targets.
[108] Di Chen,et al. Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. , 2011, Current cancer drug targets.
[109] N. Katunuma. Structure-based development of specific inhibitors for individual cathepsins and their medical applications , 2011, Proceedings of the Japan Academy. Series B, Physical and biological sciences.
[110] K. Brix,et al. Imaging of protease functions--current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues. , 2011, Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia.
[111] N. Rawlings. Peptidase inhibitors in the MEROPS database. , 2010, Biochimie.
[112] Oliver Schilling,et al. Proteomic techniques and activity-based probes for the system-wide study of proteolysis. , 2010, Biochimie.
[113] B. Turk,et al. Lysosomal-mitochondrial cross-talk during cell death. , 2010, Mitochondrion.
[114] T. Reinheckel,et al. Specialized roles for cysteine cathepsins in health and disease. , 2010, The Journal of clinical investigation.
[115] Benjamin F. Cravatt,et al. Activity-based protein profiling for biochemical pathway discovery in cancer , 2010, Nature Reviews Cancer.
[116] M. Kindy,et al. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease , 2010, Biological chemistry.
[117] M. Bogyo,et al. Nuclear cysteine cathepsin variants in thyroid carcinoma cells , 2010, Biological chemistry.
[118] Pitter F. Huesgen,et al. Proteome-wide analysis of protein carboxy termini: C terminomics , 2010, Nature Methods.
[119] F. Avilés,et al. Complementary positional proteomics for screening substrates of endo- and exoproteases , 2010, Nature Methods.
[120] Ursula Pieper,et al. Prediction of protease substrates using sequence and structure features , 2010, Bioinform..
[121] H. Simon,et al. Cathepsins and their involvement in immune responses. , 2010, Swiss medical weekly.
[122] M. Percival,et al. Therapeutic utility and medicinal chemistry of cathepsin C inhibitors. , 2010, Current topics in medicinal chemistry.
[123] N. Kopitar-Jerala,et al. Stefin B Interacts with Histones and Cathepsin L in the Nucleus* , 2010, The Journal of Biological Chemistry.
[124] Jon J Briggs,et al. Cystatin E/M suppresses legumain activity and invasion of human melanoma , 2010, BMC Cancer.
[125] Christopher M. Overall,et al. Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting , 2009, Nature Reviews Drug Discovery.
[126] D. Turk,et al. Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions , 2009, BMC Biochemistry.
[127] P. Saftig,et al. Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function , 2009, Nature Reviews Molecular Cell Biology.
[128] V. Quesada,et al. Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. , 2009, The Journal of clinical investigation.
[129] M. Bogyo,et al. Comparative Assessment of Substrates and Activity Based Probes as Tools for Non-Invasive Optical Imaging of Cysteine Protease Activity , 2009, PloS one.
[130] J. O’Sullivan,et al. Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer , 2009, International journal of cancer.
[131] C. Peters,et al. Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases , 2009, Biological chemistry.
[132] V. Turk,et al. Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?* , 2009, The Journal of Biological Chemistry.
[133] K. Brix,et al. Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation , 2009, Biological chemistry.
[134] D. Brömme,et al. Cathepsin K inhibitors for osteoporosis and potential off-target effects , 2009, Expert opinion on investigational drugs.
[135] S. Boyd,et al. Subsite cooperativity in protease specificity , 2009, Biological chemistry.
[136] C. Morales,et al. The interactomics of sortilin: an ancient lysosomal receptor evolving new functions. , 2009, Histology and histopathology.
[137] B. Wiederanders,et al. Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases , 2009, Biological chemistry.
[138] K. Ye,et al. Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome , 2009, Proceedings of the National Academy of Sciences.
[139] J. Potempa,et al. Corruption of Innate Immunity by Bacterial Proteases , 2008, Journal of Innate Immunity.
[140] C. López-Otín,et al. Proteases: Multifunctional Enzymes in Life and Disease* , 2008, Journal of Biological Chemistry.
[141] Benjamin A. Garcia,et al. Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation , 2008, Cell.
[142] R. Clark. Oxidative stress and "senescent" fibroblasts in non-healing wounds as potential therapeutic targets. , 2008, The Journal of investigative dermatology.
[143] C. Overall,et al. Protease proteomics: revealing protease in vivo functions using systems biology approaches. , 2008, Molecular aspects of medicine.
[144] G. Blum,et al. Use of fluorescent imaging to investigate pathological protease activity. , 2008, Current opinion in drug discovery & development.
[145] H. Demuth,et al. Alternative pathways for production of β-amyloid peptides of Alzheimer's disease , 2008, Biological chemistry.
[146] G. Salvesen,et al. Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues* , 2008, Journal of Biological Chemistry.
[147] N. Rousselet,et al. Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region. , 2008, The Biochemical journal.
[148] Oliver Schilling,et al. Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites , 2008, Nature Biotechnology.
[149] D. Turk,et al. Cystatins: biochemical and structural properties, and medical relevance. , 2008, Frontiers in bioscience : a journal and virtual library.
[150] J. Klumperman,et al. Imaging and imagination: understanding the endo-lysosomal system , 2008, Histochemistry and Cell Biology.
[151] K. Brix,et al. Cysteine cathepsins: cellular roadmap to different functions. , 2008, Biochimie.
[152] O. Vasiljeva,et al. Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. , 2008, Biochimie.
[153] J. Joyce,et al. Cysteine cathepsin proteases as pharmacological targets in cancer. , 2008, Trends in pharmacological sciences.
[154] J. Whisstock,et al. DNA Accelerates the Inhibition of Human Cathepsin V by Serpins* , 2007, Journal of Biological Chemistry.
[155] Raluca Ostafe,et al. Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. , 2007, European journal of cell biology.
[156] C. López-Otín,et al. Emerging roles of proteases in tumour suppression , 2007, Nature Reviews Cancer.
[157] Simon C Watkins,et al. An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury , 2007, Cell.
[158] Lennart Martens,et al. A la carte proteomics with an emphasis on gel‐free techniques , 2007, Proteomics.
[159] B. Turk,et al. Protease signalling in cell death: caspases versus cysteine cathepsins , 2007, FEBS letters.
[160] C. Jefferies,et al. Inhibition of cathepsin L-like proteases by cathepsin V propeptide , 2007, Biological chemistry.
[161] Christopher M. Overall,et al. In search of partners: linking extracellular proteases to substrates , 2007, Nature Reviews Molecular Cell Biology.
[162] O. Vasiljeva,et al. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. , 2007, Current pharmaceutical design.
[163] J. Joyce,et al. Cysteine Cathepsins and the Cutting Edge of Cancer Invasion , 2007, Cell cycle.
[164] S. Zahler,et al. RGD-dependent Binding of Procathepsin X to Integrin αvβ3 Mediates Cell-adhesive Properties* , 2006, Journal of Biological Chemistry.
[165] L. Mach,et al. The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes , 2006, Journal of Cell Science.
[166] Bonnie F. Sloane,et al. Cysteine cathepsins: multifunctional enzymes in cancer , 2006, Nature Reviews Cancer.
[167] B. Turk. Targeting proteases: successes, failures and future prospects , 2006, Nature Reviews Drug Discovery.
[168] J. Whisstock,et al. An overview of the serpin superfamily , 2006, Genome Biology.
[169] D. Hanahan,et al. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. , 2006, Genes & development.
[170] Christopher M. Overall,et al. Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer , 2006, Cancer and Metastasis Reviews.
[171] C. Van Noorden,et al. Antiprotease therapy in cancer: hot or not? , 2006, Expert opinion on biological therapy.
[172] N. Nagaraj,et al. Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion. , 2006, Life sciences.
[173] S. Zahler,et al. RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties. , 2006, The Journal of biological chemistry.
[174] A. Baici,et al. Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death , 2006, Biological chemistry.
[175] Faye M. Rosin,et al. Moonlighting vacuolar protease: multiple jobs for a busy protein. , 2005, Trends in plant science.
[176] B. Manoury,et al. Asparaginyl endopeptidase: case history of a class II MHC compartment protease , 2005, Immunological reviews.
[177] H. Lehrach,et al. A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome , 2005, Cell.
[178] C. Duve. The lysosome turns fifty , 2005, Nature Cell Biology.
[179] R. Pederson,et al. Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors. , 2005, Biochimica et biophysica acta.
[180] R. Maehr,et al. Asparagine Endopeptidase Is Not Essential for Class II MHC Antigen Presentation but Is Required for Processing of Cathepsin L in Mice1 , 2005, The Journal of Immunology.
[181] N. Seidah,et al. Dual regulation of the LDL receptor--some clarity and new questions. , 2005, Cell metabolism.
[182] A. Wahl,et al. In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[183] F. Bestvater,et al. The C-terminal subunit of artificially truncated human cathepsin B mediates its nuclear targeting and contributes to cell viability , 2005, BMC Cell Biology.
[184] D. Hanahan,et al. Multiple Roles for Cysteine Cathepsins in Cancer , 2004, Cell cycle.
[185] G. Csucs,et al. Exon Skipping of Cathepsin B , 2004, Journal of Biological Chemistry.
[186] B. Goulet,et al. Complete and Limited Proteolysis in Cell Cycle Progression , 2004, Cell cycle.
[187] H. Chapman,et al. Cathepsins as transcriptional activators? , 2004, Developmental cell.
[188] M. Bogyo,et al. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. , 2004, Molecular cell.
[189] Izabela Berdowska,et al. Cysteine proteases as disease markers. , 2004, Clinica chimica acta; international journal of clinical chemistry.
[190] A. Turkewitz. Out with a Bang! Tetrahymena as a Model System to Study Secretory Granule Biogenesis , 2004, Traffic.
[191] Bonnie F. Sloane,et al. Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells. , 2003, Neoplasia.
[192] C. Watts,et al. Multistep Autoactivation of Asparaginyl Endopeptidase in Vitro and in Vivo* , 2003, Journal of Biological Chemistry.
[193] H. Nakanishi. Neuronal and microglial cathepsins in aging and age-related diseases , 2003, Ageing Research Reviews.
[194] B. Wiederanders,et al. Functions of propeptide parts in cysteine proteases. , 2003, Current protein & peptide science.
[195] Bonnie F. Sloane,et al. Cathepsin B and its role(s) in cancer progression. , 2003, Biochemical Society symposium.
[196] Mikio Nishimura,et al. Biosynthetic Processing of Cathepsins and Lysosomal Degradation Are Abolished in Asparaginyl Endopeptidase-deficient Mice* , 2003, Journal of Biological Chemistry.
[197] X. Puente,et al. Human and mouse proteases: a comparative genomic approach , 2003, Nature Reviews Genetics.
[198] J. Deussing,et al. Thyroid functions of mouse cathepsins B, K, and L. , 2003, The Journal of clinical investigation.
[199] Cheng Liu,et al. Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. , 2003, Cancer research.
[200] Christoph Peters,et al. Toward Computer-Based Cleavage Site Prediction of Cysteine Endopeptidases , 2003, Biological chemistry.
[201] G. Csucs,et al. Exploring the Role of 5’ Alternative Splicing and of the 3’-Untranslated Region of Cathepsin B mRNA , 2003, Biological chemistry.
[202] V. Herzog,et al. Trafficking of lysosomal cathepsin B—green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment , 2002, Journal of Cell Science.
[203] M. Freeman,et al. Intramembrane proteolysis controls diverse signalling pathways throughout evolution. , 2002, Current opinion in genetics & development.
[204] A. Baici,et al. Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes. , 2002, The Biochemical journal.
[205] S. S. Chauhan,et al. Identification and characterization of a novel human cathepsin L splice variant. , 2002, Gene.
[206] B. Fingleton,et al. Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations , 2002, Science.
[207] B. Henderson. Post-Transcriptional Regulation , 2002 .
[208] L. Mach. Biosynthesis of Lysosomal Proteinases in Health and Disease , 2002, Biological chemistry.
[209] V. Herzog,et al. Thyroid Stimulating Hormone Upregulates Secretion of Cathepsin B from Thyroid Epithelial Cells , 2002, Biological chemistry.
[210] Emma J. Blott,et al. Secretory lysosomes , 2002, Nature Reviews Molecular Cell Biology.
[211] B. Wiederanders,et al. Splice Variants of Human Cathepsin L mRNA Show Different Expression Rates , 2001, Biological chemistry.
[212] J. Deussing,et al. Towards Specific Functions of Lysosomal Cysteine Peptidases: Phenotypes of Mice Deficient for Cathepsin B or Cathepsin L , 2001, Biological chemistry.
[213] J. Bonifacino,et al. The molecular machinery for lysosome biogenesis * , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.
[214] W. Huttner,et al. Secretory granule biogenesis: rafting to the SNARE. , 2001, Trends in cell biology.
[215] V. Herzog,et al. Cysteine Proteinases Mediate Extracellular Prohormone Processing in the Thyroid , 2001, Biological chemistry.
[216] V. Herzog,et al. Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. , 2000, Journal of cell science.
[217] H Lippert,et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. , 2000, The Journal of clinical investigation.
[218] N. Andrews,et al. Regulated secretion of conventional lysosomes. , 2000, Trends in cell biology.
[219] A. Rudensky,et al. The role of lysosomal proteinases in MHC class Il‐mediated antigen processing and presentation , 1999, Immunological reviews.
[220] Hidde L. Ploegh,et al. Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells , 1999, The Journal of cell biology.
[221] M. Brown,et al. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[222] A. Barrett,et al. Inhibition of Mammalian Legumain by Some Cystatins Is Due to a Novel Second Reactive Site* , 1999, The Journal of Biological Chemistry.
[223] J. Stürzebecher,et al. Synthetic inhibitors of thrombin and factor Xa: from bench to bedside. , 1999, Thrombosis research.
[224] T. Südhof,et al. Membrane fusion and exocytosis. , 1999, Annual review of biochemistry.
[225] M. Mcgrath. The lysosomal cysteine proteases. , 1999, Annual review of biophysics and biomolecular structure.
[226] I. Nishio,et al. [Angiotensin I converting enzyme]. , 1999, Nihon rinsho. Japanese journal of clinical medicine.
[227] A. Barrett,et al. Cloning and expression of mouse legumain, a lysosomal endopeptidase. , 1998, The Biochemical journal.
[228] I. Mellman,et al. Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells , 1998, Cell.
[229] D. Peffley,et al. In Vivo Expression of an Alternatively Spliced Human Tumor Message That Encodes a Truncated Form of Cathepsin B , 1998, The Journal of Biological Chemistry.
[230] R. Ménard,et al. Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts. , 1997, Biochemistry.
[231] A. Baici,et al. Differential expression of mRNAs for endopeptidases in phenotypically modulated (`dedifferentiated') human articular chondrocytes , 1997, FEBS letters.
[232] D. Buttle,et al. Cathepsin B. , 1997, The international journal of biochemistry & cell biology.
[233] H. Chapman,et al. Emerging roles for cysteine proteases in human biology. , 1997, Annual review of physiology.
[234] V. Herzog,et al. Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells. , 1996, Endocrinology.
[235] H. Munier-Lehmann,et al. Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport. , 1996, Biochemical Society transactions.
[236] Bonnie F. Sloane,et al. Cathepsin B: multiple enzyme forms from a single gene and their relation to cancer. , 1996, Enzyme & protein.
[237] J. Wehland,et al. IrpA , is highly homologous to monocytogenesPrfA-regulated gene in Listeria Identification and characterization of a novel , 1996 .
[238] R. Huber,et al. Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors. , 1995, Biochemistry.
[239] Bonnie F. Sloane,et al. Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene. , 1995, Gene.
[240] K. Sheahan,et al. Human cathepsin B-encoding cDNAs: sequence variations in the 3'-untranslated region. , 1994, Gene.
[241] S. Ishii. Legumain: asparaginyl endopeptidase. , 1994, Methods in enzymology.
[242] A. Barrett,et al. The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays. , 1993, Archives of biochemistry and biophysics.
[243] D. Steiner,et al. Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA. , 1993, DNA and cell biology.
[244] C. Ballaun,et al. Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme. , 1992, The Biochemical journal.
[245] J. Tooze,et al. Regulated secretion of mature cathepsin B from rat exocrine pancreatic cells. , 1991, European journal of cell biology.
[246] Robert Huber,et al. The refined 2.15 A X‐ray crystal structure of human liver cathepsin B: the structural basis for its specificity. , 1991, The EMBO journal.
[247] W. Bode,et al. cystatins: protein inhibitors of cysteine proteinases , 2001 .
[248] P. Romagnoli,et al. Transcytosis in thyroid follicle cells: regulation and implications for thyroglobulin transport. , 1991, Experimental cell research.
[249] K. von Figura. Molecular recognition and targeting of lysosomal proteins. , 1991, Current opinion in cell biology.
[250] K. Howell,et al. In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome , 1990, The Journal of cell biology.
[251] R. Huber,et al. Mechanism of interaction of cysteine proteinases and their protein inhibitors as compared to the serine proteinase-inhibitor interaction. , 1990, Biological chemistry Hoppe-Seyler.
[252] K. von Figura,et al. Mannose 6-phosphate specific receptors: structure and function. , 1989, Biochemical Society transactions.
[253] I. Mellman,et al. The biogenesis of lysosomes. , 1989, Annual review of cell biology.
[254] H. Davidson,et al. Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases , 1988, Nature.
[255] R. Sutherland. Cell and environment interactions in tumor microregions: the multicell spheroid model. , 1988, Science.
[256] A. Poole,et al. Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH. , 1984, Arthritis and rheumatism.
[257] A. Varki,et al. Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing "blocking" alpha-N-acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes. , 1980, The Journal of biological chemistry.