Proteolysis mediated by cysteine cathepsins and legumain—recent advances and cell biological challenges

[1]  S. Macedo-Ribeiro,et al.  Molecular and computational analyses of genes involved in mannose 6‐phosphate independent trafficking , 2015, Clinical genetics.

[2]  J. Kos,et al.  Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer. , 2015, Seminars in cancer biology.

[3]  K. Sandvig,et al.  LYST Affects Lysosome Size and Quantity, but not Trafficking or Degradation Through Autophagy or Endocytosis , 2014, Traffic.

[4]  O. Vasiljeva,et al.  A Role for Stefin B (Cystatin B) in Inflammation and Endotoxemia* , 2014, The Journal of Biological Chemistry.

[5]  G. Salvesen,et al.  Regulated cell death: signaling and mechanisms. , 2014, Annual review of cell and developmental biology.

[6]  C. Peters,et al.  The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length , 2014, Biological chemistry.

[7]  Laura H. Tang,et al.  Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix , 2014, Genes & development.

[8]  K. Eliceiri,et al.  SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. , 2014, The Journal of clinical investigation.

[9]  T. Reinheckel,et al.  Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo , 2014, Nature Communications.

[10]  M. Freeman,et al.  Sharpening rhomboid specificity by dimerisation and allostery , 2014, The EMBO journal.

[11]  J. Luzio,et al.  The biogenesis of lysosomes and lysosome-related organelles. , 2014, Cold Spring Harbor perspectives in biology.

[12]  James M Wright,et al.  Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension. , 2014, The Cochrane database of systematic reviews.

[13]  S. Ventura,et al.  Human Stefin B Role in Cell's Response to Misfolded Proteins and Autophagy , 2014, PloS one.

[14]  W. Hahn,et al.  Analysis of tumor- and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S , 2014, Nature Cell Biology.

[15]  I. Oglesby,et al.  miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. , 2014, American journal of respiratory and critical care medicine.

[16]  R. Solberg,et al.  Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. , 2014, Bioorganic & medicinal chemistry.

[17]  O. Vasiljeva,et al.  Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor , 2014, Angewandte Chemie.

[18]  O. Vasiljeva,et al.  Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model , 2014, Oncogene.

[19]  Frances M. Platt,et al.  Sphingolipid lysosomal storage disorders , 2014, Nature.

[20]  M. Fonović,et al.  Cysteine cathepsins and their potential in clinical therapy and biomarker discovery , 2014, Proteomics. Clinical applications.

[21]  X. Chen,et al.  Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis. , 2014, Journal of the National Cancer Institute.

[22]  Ruth Geiss-Friedlander,et al.  The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus , 2014, Cellular and Molecular Life Sciences.

[23]  J. Schilling,et al.  Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation* , 2014, The Journal of Biological Chemistry.

[24]  Rama Ranganathan,et al.  A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods , 2014, Nature Communications.

[25]  F. Levi-Schaffer,et al.  Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease* , 2014, The Journal of Biological Chemistry.

[26]  G. Cheng,et al.  Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage , 2014, Cell Research.

[27]  C. Peters,et al.  The endolysosomal cysteine cathepsins L and K are involved in macrophage‐mediated clearance of Staphylococcus aureus and the concomitant cytokine induction , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  Neil D. Rawlings,et al.  MEROPS: the database of proteolytic enzymes, their substrates and inhibitors , 2013, Nucleic Acids Res..

[29]  J. Gruenberg,et al.  ALIX and the multivesicular endosome: ALIX in Wonderland. , 2014, Trends in cell biology.

[30]  M. Groll,et al.  Applied techniques for mining natural proteasome inhibitors. , 2014, Biochimica et biophysica acta.

[31]  H. Plattner,et al.  Unicellular eukaryotes as models in cell and molecular biology: critical appraisal of their past and future value. , 2014, International review of cell and molecular biology.

[32]  S. Urban,et al.  Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity , 2013, Cell.

[33]  M. Freeman,et al.  Intramembrane proteolysis by rhomboids: catalytic mechanisms and regulatory principles. , 2013, Current opinion in structural biology.

[34]  R. Pike,et al.  The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates. , 2013, Current opinion in structural biology.

[35]  M. J. Lemieux,et al.  Untangling structure-function relationships in the rhomboid family of intramembrane proteases. , 2013, Biochimica et biophysica acta.

[36]  K. Sandhoff Metabolic and cellular bases of sphingolipidoses. , 2013, Biochemical Society transactions.

[37]  Joseph S. Briguglio,et al.  Lysosomal sorting receptors are essential for secretory granule biogenesis in Tetrahymena , 2013, The Journal of cell biology.

[38]  Bonnie F. Sloane,et al.  Proteases in Cancer: Significance for Invasion and Metastasis , 2013 .

[39]  D. Quail,et al.  Microenvironmental regulation of tumor progression and metastasis , 2014 .

[40]  Paul H. Bessette,et al.  Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index , 2013, Science Translational Medicine.

[41]  O. Schilling,et al.  Proteomic identification of protease cleavage sites: cell-biological and biomedical applications , 2013, Expert review of proteomics.

[42]  V. Turk,et al.  Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes , 2013, Cell Death and Disease.

[43]  Wan-Xi Yang,et al.  Modes of acrosin functioning during fertilization. , 2013, Gene.

[44]  M. Bogyo,et al.  Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses. , 2013, Biochemistry.

[45]  Marko Novinec,et al.  Cathepsin K: a unique collagenolytic cysteine peptidase , 2013, Biological chemistry.

[46]  G. Raposo,et al.  Lysosome-related organelles: unusual compartments become mainstream. , 2013, Current opinion in cell biology.

[47]  G. Salvesen,et al.  Caspase substrates and inhibitors. , 2013, Cold Spring Harbor perspectives in biology.

[48]  H. Brandstetter,et al.  Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation , 2013, Proceedings of the National Academy of Sciences.

[49]  T. Reinheckel On the road to inflammation: Linking lysosome disruption, lysosomal protease release and necrotic death of immune cells , 2013, Cell cycle.

[50]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[51]  M. Jäättelä,et al.  Combating apoptosis and multidrug resistant cancers by targeting lysosomes. , 2013, Cancer letters.

[52]  K. Chandran,et al.  Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death , 2013, Cell cycle.

[53]  M. Jäättelä,et al.  Lysosomal cell death at a glance , 2013, Journal of Cell Science.

[54]  M. Abrahamson,et al.  Cystatin C Properties Crucial for Uptake and Inhibition of Intracellular Target Enzymes* , 2013, The Journal of Biological Chemistry.

[55]  G. Blum,et al.  Ready, set, cleave: proteases in action. , 2013, Chemistry & biology.

[56]  M. Bogyo,et al.  Target deconvolution techniques in modern phenotypic profiling. , 2013, Current opinion in chemical biology.

[57]  G. Maelandsmo,et al.  Nuclear Legumain Activity in Colorectal Cancer , 2013, PloS one.

[58]  A. Newland,et al.  Brentuximab Vedotin: A CD30‐Directed Antibody‐Cytotoxic Drug Conjugate , 2013, Pharmacotherapy.

[59]  C. Isidoro,et al.  Cathepsins: Getting in Shape for Lysosomal Proteolysis , 2013 .

[60]  K. Brix,et al.  Proteases: Structure and Function , 2013, Springer Vienna.

[61]  K. Brix,et al.  Compartmentalization of Proteolysis , 2013 .

[62]  S. Kostrov,et al.  Handbook of proteolytic enzymes, 3rd Edition , 2013 .

[63]  K. Brix Lysosomal Proteases: Revival of the Sleeping Beauty , 2013 .

[64]  N. Rawlings,et al.  Introduction: Aspartic and Glutamic Peptidases and Their Clans , 2013 .

[65]  O. Schilling,et al.  Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances , 2013 .

[66]  C. Peters,et al.  Exploring Systemic Functions of Lysosomal Proteases: The Perspective of Genetically Modified Mouse Models , 2013 .

[67]  M. Grütter,et al.  Proteases in Death Pathways , 2013 .

[68]  S. Rose-John,et al.  ADAM Proteases in Physiology and Pathophysiology: Cleave to Function in Health or to Cause Disease , 2013 .

[69]  Marko Novinec,et al.  Kinetics of the Interaction of Peptidases with Substrates and Modifiers , 2013 .

[70]  M. Groll,et al.  Inhibitors for the Immuno‐ and Constitutive Proteasome: Current and Future Trends in Drug Development , 2012 .

[71]  Michael D. Taylor,et al.  MicroRNA 218 Acts as a Tumor Suppressor by Targeting Multiple Cancer Phenotype-associated Genes in Medulloblastoma* , 2012, The Journal of Biological Chemistry.

[72]  P. Saftig,et al.  Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon , 2012, Biological chemistry.

[73]  V. Turk,et al.  Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines , 2012, Biological chemistry.

[74]  Geoffrey I. Webb,et al.  PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites , 2012, PloS one.

[75]  M. Prata,et al.  A shortcut to the lysosome: the mannose-6-phosphate-independent pathway. , 2012, Molecular genetics and metabolism.

[76]  M. Seaman The retromer complex – endosomal protein recycling and beyond , 2012, Journal of Cell Science.

[77]  S. Kelm,et al.  Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice , 2012, Biological chemistry.

[78]  R. Guttmann,et al.  Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration , 2012, International journal of cell biology.

[79]  C. Chelala,et al.  S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells. , 2012, The American journal of pathology.

[80]  Bonnie F. Sloane,et al.  MAME models for 4D live-cell imaging of tumor: microenvironment interactions that impact malignant progression. , 2012, Journal of visualized experiments : JoVE.

[81]  J. Johnston,et al.  Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas. , 2012, Biochimie.

[82]  Kwangmeyung Kim,et al.  Protease Activity: Meeting Its Theranostic Potential , 2012, Theranostics.

[83]  T. Reinheckel,et al.  Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment , 2012, Journal of Virology.

[84]  A. Shen Clostridium difficile Toxins: Mediators of Inflammation , 2012, Journal of Innate Immunity.

[85]  M. Bogyo,et al.  New approaches for dissecting protease functions to improve probe development and drug discovery , 2012, Nature Structural &Molecular Biology.

[86]  Olga Vasiljeva,et al.  Cysteine cathepsins: From structure, function and regulation to new frontiers , 2011, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.

[87]  H. Brandstetter,et al.  Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile. , 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

[88]  V. Turk Special issue: Proteolysis 50 years after the discovery of lysosome in honor of Christian de Duve. , 2012, Biochimica et biophysica acta.

[89]  C. Liu,et al.  Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug. , 2012, Molecular pharmaceutics.

[90]  M. Kindy,et al.  Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. , 2012, Biochimica et biophysica acta.

[91]  V. Turk,et al.  Lysosomes and lysosomal cathepsins in cell death. , 2012, Biochimica et biophysica acta.

[92]  Bonnie F. Sloane,et al.  3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment. , 2012, Methods in enzymology.

[93]  M. Bogyo,et al.  Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. , 2011, Current opinion in chemical biology.

[94]  S. Urban,et al.  The rhomboid protease family: a decade of progress on function and mechanism , 2011, Genome Biology.

[95]  O. Schilling,et al.  Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. , 2011, Journal of proteome research.

[96]  J. M. Ortega,et al.  Nucleoplasmic calcium regulates cell proliferation through legumain. , 2011, Journal of hepatology.

[97]  P. Seglen,et al.  Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain , 2011, Autophagy.

[98]  Christoph Peters,et al.  Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. , 2011, Nature nanotechnology.

[99]  C. Overall,et al.  TopFIND, a knowledgebase linking protein termini with function , 2011, Nature Methods.

[100]  M. Bogyo,et al.  Cathepsin B trafficking in thyroid carcinoma cells , 2011, Thyroid research.

[101]  P. Saftig,et al.  Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits , 2011, BMC Neuroscience.

[102]  Constance J Jeffery,et al.  Proteins with neomorphic moonlighting functions in disease , 2011, IUBMB life.

[103]  D. Führer,et al.  Thyroid Cathepsin K: Roles in Physiology and Thyroid Disease , 2011 .

[104]  Harald Steiner,et al.  Regulated intramembrane proteolysis – lessons from amyloid precursor protein processing , 2011, Journal of neurochemistry.

[105]  R. A. Mir,et al.  Post-transcriptional regulation of human cathepsin L expression , 2011, Biological chemistry.

[106]  J. Joyce,et al.  Proteolytic networks in cancer. , 2011, Trends in cell biology.

[107]  G. Arancia,et al.  Autophagy: Molecular mechanisms and their implications for anticancer therapies. , 2011, Current cancer drug targets.

[108]  Di Chen,et al.  Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. , 2011, Current cancer drug targets.

[109]  N. Katunuma Structure-based development of specific inhibitors for individual cathepsins and their medical applications , 2011, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[110]  K. Brix,et al.  Imaging of protease functions--current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues. , 2011, Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia.

[111]  N. Rawlings Peptidase inhibitors in the MEROPS database. , 2010, Biochimie.

[112]  Oliver Schilling,et al.  Proteomic techniques and activity-based probes for the system-wide study of proteolysis. , 2010, Biochimie.

[113]  B. Turk,et al.  Lysosomal-mitochondrial cross-talk during cell death. , 2010, Mitochondrion.

[114]  T. Reinheckel,et al.  Specialized roles for cysteine cathepsins in health and disease. , 2010, The Journal of clinical investigation.

[115]  Benjamin F. Cravatt,et al.  Activity-based protein profiling for biochemical pathway discovery in cancer , 2010, Nature Reviews Cancer.

[116]  M. Kindy,et al.  Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease , 2010, Biological chemistry.

[117]  M. Bogyo,et al.  Nuclear cysteine cathepsin variants in thyroid carcinoma cells , 2010, Biological chemistry.

[118]  Pitter F. Huesgen,et al.  Proteome-wide analysis of protein carboxy termini: C terminomics , 2010, Nature Methods.

[119]  F. Avilés,et al.  Complementary positional proteomics for screening substrates of endo- and exoproteases , 2010, Nature Methods.

[120]  Ursula Pieper,et al.  Prediction of protease substrates using sequence and structure features , 2010, Bioinform..

[121]  H. Simon,et al.  Cathepsins and their involvement in immune responses. , 2010, Swiss medical weekly.

[122]  M. Percival,et al.  Therapeutic utility and medicinal chemistry of cathepsin C inhibitors. , 2010, Current topics in medicinal chemistry.

[123]  N. Kopitar-Jerala,et al.  Stefin B Interacts with Histones and Cathepsin L in the Nucleus* , 2010, The Journal of Biological Chemistry.

[124]  Jon J Briggs,et al.  Cystatin E/M suppresses legumain activity and invasion of human melanoma , 2010, BMC Cancer.

[125]  Christopher M. Overall,et al.  Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting , 2009, Nature Reviews Drug Discovery.

[126]  D. Turk,et al.  Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions , 2009, BMC Biochemistry.

[127]  P. Saftig,et al.  Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function , 2009, Nature Reviews Molecular Cell Biology.

[128]  V. Quesada,et al.  Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. , 2009, The Journal of clinical investigation.

[129]  M. Bogyo,et al.  Comparative Assessment of Substrates and Activity Based Probes as Tools for Non-Invasive Optical Imaging of Cysteine Protease Activity , 2009, PloS one.

[130]  J. O’Sullivan,et al.  Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer , 2009, International journal of cancer.

[131]  C. Peters,et al.  Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases , 2009, Biological chemistry.

[132]  V. Turk,et al.  Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?* , 2009, The Journal of Biological Chemistry.

[133]  K. Brix,et al.  Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation , 2009, Biological chemistry.

[134]  D. Brömme,et al.  Cathepsin K inhibitors for osteoporosis and potential off-target effects , 2009, Expert opinion on investigational drugs.

[135]  S. Boyd,et al.  Subsite cooperativity in protease specificity , 2009, Biological chemistry.

[136]  C. Morales,et al.  The interactomics of sortilin: an ancient lysosomal receptor evolving new functions. , 2009, Histology and histopathology.

[137]  B. Wiederanders,et al.  Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases , 2009, Biological chemistry.

[138]  K. Ye,et al.  Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome , 2009, Proceedings of the National Academy of Sciences.

[139]  J. Potempa,et al.  Corruption of Innate Immunity by Bacterial Proteases , 2008, Journal of Innate Immunity.

[140]  C. López-Otín,et al.  Proteases: Multifunctional Enzymes in Life and Disease* , 2008, Journal of Biological Chemistry.

[141]  Benjamin A. Garcia,et al.  Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation , 2008, Cell.

[142]  R. Clark Oxidative stress and "senescent" fibroblasts in non-healing wounds as potential therapeutic targets. , 2008, The Journal of investigative dermatology.

[143]  C. Overall,et al.  Protease proteomics: revealing protease in vivo functions using systems biology approaches. , 2008, Molecular aspects of medicine.

[144]  G. Blum,et al.  Use of fluorescent imaging to investigate pathological protease activity. , 2008, Current opinion in drug discovery & development.

[145]  H. Demuth,et al.  Alternative pathways for production of β-amyloid peptides of Alzheimer's disease , 2008, Biological chemistry.

[146]  G. Salvesen,et al.  Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues* , 2008, Journal of Biological Chemistry.

[147]  N. Rousselet,et al.  Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region. , 2008, The Biochemical journal.

[148]  Oliver Schilling,et al.  Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites , 2008, Nature Biotechnology.

[149]  D. Turk,et al.  Cystatins: biochemical and structural properties, and medical relevance. , 2008, Frontiers in bioscience : a journal and virtual library.

[150]  J. Klumperman,et al.  Imaging and imagination: understanding the endo-lysosomal system , 2008, Histochemistry and Cell Biology.

[151]  K. Brix,et al.  Cysteine cathepsins: cellular roadmap to different functions. , 2008, Biochimie.

[152]  O. Vasiljeva,et al.  Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. , 2008, Biochimie.

[153]  J. Joyce,et al.  Cysteine cathepsin proteases as pharmacological targets in cancer. , 2008, Trends in pharmacological sciences.

[154]  J. Whisstock,et al.  DNA Accelerates the Inhibition of Human Cathepsin V by Serpins* , 2007, Journal of Biological Chemistry.

[155]  Raluca Ostafe,et al.  Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. , 2007, European journal of cell biology.

[156]  C. López-Otín,et al.  Emerging roles of proteases in tumour suppression , 2007, Nature Reviews Cancer.

[157]  Simon C Watkins,et al.  An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury , 2007, Cell.

[158]  Lennart Martens,et al.  A la carte proteomics with an emphasis on gel‐free techniques , 2007, Proteomics.

[159]  B. Turk,et al.  Protease signalling in cell death: caspases versus cysteine cathepsins , 2007, FEBS letters.

[160]  C. Jefferies,et al.  Inhibition of cathepsin L-like proteases by cathepsin V propeptide , 2007, Biological chemistry.

[161]  Christopher M. Overall,et al.  In search of partners: linking extracellular proteases to substrates , 2007, Nature Reviews Molecular Cell Biology.

[162]  O. Vasiljeva,et al.  Emerging roles of cysteine cathepsins in disease and their potential as drug targets. , 2007, Current pharmaceutical design.

[163]  J. Joyce,et al.  Cysteine Cathepsins and the Cutting Edge of Cancer Invasion , 2007, Cell cycle.

[164]  S. Zahler,et al.  RGD-dependent Binding of Procathepsin X to Integrin αvβ3 Mediates Cell-adhesive Properties* , 2006, Journal of Biological Chemistry.

[165]  L. Mach,et al.  The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes , 2006, Journal of Cell Science.

[166]  Bonnie F. Sloane,et al.  Cysteine cathepsins: multifunctional enzymes in cancer , 2006, Nature Reviews Cancer.

[167]  B. Turk Targeting proteases: successes, failures and future prospects , 2006, Nature Reviews Drug Discovery.

[168]  J. Whisstock,et al.  An overview of the serpin superfamily , 2006, Genome Biology.

[169]  D. Hanahan,et al.  Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. , 2006, Genes & development.

[170]  Christopher M. Overall,et al.  Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer , 2006, Cancer and Metastasis Reviews.

[171]  C. Van Noorden,et al.  Antiprotease therapy in cancer: hot or not? , 2006, Expert opinion on biological therapy.

[172]  N. Nagaraj,et al.  Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion. , 2006, Life sciences.

[173]  S. Zahler,et al.  RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties. , 2006, The Journal of biological chemistry.

[174]  A. Baici,et al.  Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death , 2006, Biological chemistry.

[175]  Faye M. Rosin,et al.  Moonlighting vacuolar protease: multiple jobs for a busy protein. , 2005, Trends in plant science.

[176]  B. Manoury,et al.  Asparaginyl endopeptidase: case history of a class II MHC compartment protease , 2005, Immunological reviews.

[177]  H. Lehrach,et al.  A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome , 2005, Cell.

[178]  C. Duve The lysosome turns fifty , 2005, Nature Cell Biology.

[179]  R. Pederson,et al.  Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors. , 2005, Biochimica et biophysica acta.

[180]  R. Maehr,et al.  Asparagine Endopeptidase Is Not Essential for Class II MHC Antigen Presentation but Is Required for Processing of Cathepsin L in Mice1 , 2005, The Journal of Immunology.

[181]  N. Seidah,et al.  Dual regulation of the LDL receptor--some clarity and new questions. , 2005, Cell metabolism.

[182]  A. Wahl,et al.  In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[183]  F. Bestvater,et al.  The C-terminal subunit of artificially truncated human cathepsin B mediates its nuclear targeting and contributes to cell viability , 2005, BMC Cell Biology.

[184]  D. Hanahan,et al.  Multiple Roles for Cysteine Cathepsins in Cancer , 2004, Cell cycle.

[185]  G. Csucs,et al.  Exon Skipping of Cathepsin B , 2004, Journal of Biological Chemistry.

[186]  B. Goulet,et al.  Complete and Limited Proteolysis in Cell Cycle Progression , 2004, Cell cycle.

[187]  H. Chapman,et al.  Cathepsins as transcriptional activators? , 2004, Developmental cell.

[188]  M. Bogyo,et al.  A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. , 2004, Molecular cell.

[189]  Izabela Berdowska,et al.  Cysteine proteases as disease markers. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[190]  A. Turkewitz Out with a Bang! Tetrahymena as a Model System to Study Secretory Granule Biogenesis , 2004, Traffic.

[191]  Bonnie F. Sloane,et al.  Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells. , 2003, Neoplasia.

[192]  C. Watts,et al.  Multistep Autoactivation of Asparaginyl Endopeptidase in Vitro and in Vivo* , 2003, Journal of Biological Chemistry.

[193]  H. Nakanishi Neuronal and microglial cathepsins in aging and age-related diseases , 2003, Ageing Research Reviews.

[194]  B. Wiederanders,et al.  Functions of propeptide parts in cysteine proteases. , 2003, Current protein & peptide science.

[195]  Bonnie F. Sloane,et al.  Cathepsin B and its role(s) in cancer progression. , 2003, Biochemical Society symposium.

[196]  Mikio Nishimura,et al.  Biosynthetic Processing of Cathepsins and Lysosomal Degradation Are Abolished in Asparaginyl Endopeptidase-deficient Mice* , 2003, Journal of Biological Chemistry.

[197]  X. Puente,et al.  Human and mouse proteases: a comparative genomic approach , 2003, Nature Reviews Genetics.

[198]  J. Deussing,et al.  Thyroid functions of mouse cathepsins B, K, and L. , 2003, The Journal of clinical investigation.

[199]  Cheng Liu,et al.  Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. , 2003, Cancer research.

[200]  Christoph Peters,et al.  Toward Computer-Based Cleavage Site Prediction of Cysteine Endopeptidases , 2003, Biological chemistry.

[201]  G. Csucs,et al.  Exploring the Role of 5’ Alternative Splicing and of the 3’-Untranslated Region of Cathepsin B mRNA , 2003, Biological chemistry.

[202]  V. Herzog,et al.  Trafficking of lysosomal cathepsin B—green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment , 2002, Journal of Cell Science.

[203]  M. Freeman,et al.  Intramembrane proteolysis controls diverse signalling pathways throughout evolution. , 2002, Current opinion in genetics & development.

[204]  A. Baici,et al.  Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes. , 2002, The Biochemical journal.

[205]  S. S. Chauhan,et al.  Identification and characterization of a novel human cathepsin L splice variant. , 2002, Gene.

[206]  B. Fingleton,et al.  Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations , 2002, Science.

[207]  B. Henderson Post-Transcriptional Regulation , 2002 .

[208]  L. Mach Biosynthesis of Lysosomal Proteinases in Health and Disease , 2002, Biological chemistry.

[209]  V. Herzog,et al.  Thyroid Stimulating Hormone Upregulates Secretion of Cathepsin B from Thyroid Epithelial Cells , 2002, Biological chemistry.

[210]  Emma J. Blott,et al.  Secretory lysosomes , 2002, Nature Reviews Molecular Cell Biology.

[211]  B. Wiederanders,et al.  Splice Variants of Human Cathepsin L mRNA Show Different Expression Rates , 2001, Biological chemistry.

[212]  J. Deussing,et al.  Towards Specific Functions of Lysosomal Cysteine Peptidases: Phenotypes of Mice Deficient for Cathepsin B or Cathepsin L , 2001, Biological chemistry.

[213]  J. Bonifacino,et al.  The molecular machinery for lysosome biogenesis * , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

[214]  W. Huttner,et al.  Secretory granule biogenesis: rafting to the SNARE. , 2001, Trends in cell biology.

[215]  V. Herzog,et al.  Cysteine Proteinases Mediate Extracellular Prohormone Processing in the Thyroid , 2001, Biological chemistry.

[216]  V. Herzog,et al.  Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. , 2000, Journal of cell science.

[217]  H Lippert,et al.  Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. , 2000, The Journal of clinical investigation.

[218]  N. Andrews,et al.  Regulated secretion of conventional lysosomes. , 2000, Trends in cell biology.

[219]  A. Rudensky,et al.  The role of lysosomal proteinases in MHC class Il‐mediated antigen processing and presentation , 1999, Immunological reviews.

[220]  Hidde L. Ploegh,et al.  Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells , 1999, The Journal of cell biology.

[221]  M. Brown,et al.  A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[222]  A. Barrett,et al.  Inhibition of Mammalian Legumain by Some Cystatins Is Due to a Novel Second Reactive Site* , 1999, The Journal of Biological Chemistry.

[223]  J. Stürzebecher,et al.  Synthetic inhibitors of thrombin and factor Xa: from bench to bedside. , 1999, Thrombosis research.

[224]  T. Südhof,et al.  Membrane fusion and exocytosis. , 1999, Annual review of biochemistry.

[225]  M. Mcgrath The lysosomal cysteine proteases. , 1999, Annual review of biophysics and biomolecular structure.

[226]  I. Nishio,et al.  [Angiotensin I converting enzyme]. , 1999, Nihon rinsho. Japanese journal of clinical medicine.

[227]  A. Barrett,et al.  Cloning and expression of mouse legumain, a lysosomal endopeptidase. , 1998, The Biochemical journal.

[228]  I. Mellman,et al.  Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells , 1998, Cell.

[229]  D. Peffley,et al.  In Vivo Expression of an Alternatively Spliced Human Tumor Message That Encodes a Truncated Form of Cathepsin B , 1998, The Journal of Biological Chemistry.

[230]  R. Ménard,et al.  Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts. , 1997, Biochemistry.

[231]  A. Baici,et al.  Differential expression of mRNAs for endopeptidases in phenotypically modulated (`dedifferentiated') human articular chondrocytes , 1997, FEBS letters.

[232]  D. Buttle,et al.  Cathepsin B. , 1997, The international journal of biochemistry & cell biology.

[233]  H. Chapman,et al.  Emerging roles for cysteine proteases in human biology. , 1997, Annual review of physiology.

[234]  V. Herzog,et al.  Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells. , 1996, Endocrinology.

[235]  H. Munier-Lehmann,et al.  Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport. , 1996, Biochemical Society transactions.

[236]  Bonnie F. Sloane,et al.  Cathepsin B: multiple enzyme forms from a single gene and their relation to cancer. , 1996, Enzyme & protein.

[237]  J. Wehland,et al.  IrpA , is highly homologous to monocytogenesPrfA-regulated gene in Listeria Identification and characterization of a novel , 1996 .

[238]  R. Huber,et al.  Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors. , 1995, Biochemistry.

[239]  Bonnie F. Sloane,et al.  Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene. , 1995, Gene.

[240]  K. Sheahan,et al.  Human cathepsin B-encoding cDNAs: sequence variations in the 3'-untranslated region. , 1994, Gene.

[241]  S. Ishii Legumain: asparaginyl endopeptidase. , 1994, Methods in enzymology.

[242]  A. Barrett,et al.  The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays. , 1993, Archives of biochemistry and biophysics.

[243]  D. Steiner,et al.  Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA. , 1993, DNA and cell biology.

[244]  C. Ballaun,et al.  Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme. , 1992, The Biochemical journal.

[245]  J. Tooze,et al.  Regulated secretion of mature cathepsin B from rat exocrine pancreatic cells. , 1991, European journal of cell biology.

[246]  Robert Huber,et al.  The refined 2.15 A X‐ray crystal structure of human liver cathepsin B: the structural basis for its specificity. , 1991, The EMBO journal.

[247]  W. Bode,et al.  cystatins: protein inhibitors of cysteine proteinases , 2001 .

[248]  P. Romagnoli,et al.  Transcytosis in thyroid follicle cells: regulation and implications for thyroglobulin transport. , 1991, Experimental cell research.

[249]  K. von Figura Molecular recognition and targeting of lysosomal proteins. , 1991, Current opinion in cell biology.

[250]  K. Howell,et al.  In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome , 1990, The Journal of cell biology.

[251]  R. Huber,et al.  Mechanism of interaction of cysteine proteinases and their protein inhibitors as compared to the serine proteinase-inhibitor interaction. , 1990, Biological chemistry Hoppe-Seyler.

[252]  K. von Figura,et al.  Mannose 6-phosphate specific receptors: structure and function. , 1989, Biochemical Society transactions.

[253]  I. Mellman,et al.  The biogenesis of lysosomes. , 1989, Annual review of cell biology.

[254]  H. Davidson,et al.  Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases , 1988, Nature.

[255]  R. Sutherland Cell and environment interactions in tumor microregions: the multicell spheroid model. , 1988, Science.

[256]  A. Poole,et al.  Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH. , 1984, Arthritis and rheumatism.

[257]  A. Varki,et al.  Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing "blocking" alpha-N-acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes. , 1980, The Journal of biological chemistry.