Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug.
暂无分享,去创建一个
Michael S Roberts | Michael Weiss | M. Roberts | M. Weiss | D. Hung | P. Masci | Brett McWhinney | P. Chang | B. McWhinney | Daniel Y Hung | Ping Chang | Kee Cheung | Paul P Masci | K. Cheung
[1] Michael S. Roberts,et al. Modeling of Hepatic Elimination and Organ Distribution Kinetics with the Extended Convection-Dispersion Model , 1999, Journal of Pharmacokinetics and Biopharmaceutics.
[2] J. Miners,et al. Nonspecific binding of drugs to human liver microsomes. , 2000, British journal of clinical pharmacology.
[3] J. Villeneuve,et al. Hepatic circulation in cirrhosis. , 1985, Clinics in gastroenterology.
[4] D. Morgan,et al. Clinical Pharmacokinetic and Pharmacodynamic Considerations in Patients with Liver Disease , 1995, Clinical pharmacokinetics.
[5] J. Peters,et al. CYP2E1 is not involved in early alcohol-induced liver injury. , 1999, American journal of physiology. Gastrointestinal and liver physiology.
[6] C. Goresky,et al. Uptake of lactate by the liver: effect of red blood cell carriage. , 2000, American journal of physiology. Gastrointestinal and liver physiology.
[7] M. Roberts,et al. Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process. , 2001, The Journal of pharmacology and experimental therapeutics.
[8] C. Shim,et al. Functional Impairment of Sinusoidal Membrane Transport of Organic Cations in Rats with CCl4-Induced Hepatic Failure , 2000, Pharmaceutical Research.
[9] K. Chatamra,et al. High yield micronodular cirrhosis in the rat. , 1982, Gastroenterology.
[10] A. Zimmermann,et al. Aminopyrine N-demethylation by rats with liver cirrhosis. Evidence for the intact cell hypothesis. A morphometric-functional study. , 1987, Gastroenterology.
[11] C. Goresky,et al. Sulfation of acetaminophen by the perfused rat liver: The effect of red blood cell carriage , 1995, Hepatology.
[12] Michael E. Winter,et al. Basic Clinical Pharmacokinetics , 1980 .
[13] J. Villeneuve,et al. Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat , 1993, Hepatology.
[14] M. Roberts,et al. Kinetic analysis of vascular marker distribution in perfused rat livers after regeneration following partial hepatectomy. , 1998, Journal of hepatology.
[15] S. Sherlock,et al. Diseases of the Liver and Biliary System , 1955 .
[16] A. Zimmermann,et al. Aminopyrine N-demethylation by rats with liver cirrhosis , 1987 .
[17] H. Imamura,et al. A Simple and Rapid Fluorometric Determination Method of α1-Acid Glycoprotein in Serum Using Quinaldine Red , 1994, Pharmaceutical Research.
[18] J. Villeneuve,et al. Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple‐indicator dilution technique , 1993, Hepatology.
[19] G. Minuk,et al. Liver regeneration and the effect of exogenous putrescine on regenerative activity after partial hepatectomy in cirrhotic rats , 1992, Hepatology.
[20] M. Roberts,et al. Commentary: using the convection-dispersion model and transit time density functions in the analysis of organ distribution kinetics. , 2000, Journal of pharmaceutical sciences.
[21] C. Elsing,et al. Hepatocellular Na+/H+ exchange is activated at transcriptional and posttranscriptional levels in rat biliary cirrhosis. , 1994, Gastroenterology.
[22] M. Roberts,et al. Cytoplasmic binding and disposition kinetics of diclofenac in the isolated perfused rat liver , 2000, British journal of pharmacology.
[23] J. Villeneuve,et al. Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis. , 2000, Canadian journal of physiology and pharmacology.
[24] T. Sohda,et al. Role of Kupffer cell-derived reactive oxygen intermediates in alcoholic liver disease in rats in vivo. , 1996, Alcoholism, clinical and experimental research.
[25] F Varin,et al. Hepatic microcirculation in the perfused cirrhotic rat liver. , 1985, The Journal of clinical investigation.
[26] Y. Tochino,et al. Quantitative determination of cytochrome P-450 in rat liver homogenate. , 1976, Analytical biochemistry.
[27] O. H. Lowry,et al. Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.
[28] M. Roberts,et al. On the validity of the dispersion model of hepatic drug elimination when intravascular transit time densities are long-tailed. , 1997, Bulletin of mathematical biology.
[29] R. Callaghan,et al. Hepatic enzyme activity is the major factor determining elimination rate of high‐clearance drugs in cirrhosis , 1993, Hepatology.
[30] S. Krähenbühl,et al. Relationship between hepatic mitochondrial functions in vivo and in vitro in rats with carbon tetrachloride-induced liver cirrhosis. , 2000, Journal of hepatology.
[31] J. Dufour,et al. Increased hepatic lysosomal activity in biliary cirrhosis originates from hepatocytes rather than from macrophages. , 1994, Journal of hepatology.
[32] V. Rodighiero. Effects of Liver Disease on Pharmacokinetics , 1999, Clinical pharmacokinetics.
[33] R. Obach,et al. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. , 1997, Drug metabolism and disposition: the biological fate of chemicals.
[34] E. B. D. Brinkman-van der Linden,et al. Glycosylation of alpha 1-acid glycoprotein in septic shock: changes in degree of branching and in expression of sialyl Lewis(x) groups. , 1996, Glycoconjugate journal.
[35] M. Roberts,et al. An optimized model for rat liver perfusion studies. , 1996, The Journal of surgical research.