Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.

Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took ad...

[1]  L. Birnbaum.  The mechanism of dioxin toxicity: relationship to risk assessment. , 1994, Environmental health perspectives.

[2]  O. Mäkelä,et al.  Induction of aryl hydrocarbon hydroxylase activity and pulmonary carcinoma , 1979, International journal of cancer.

[3]  D. Nebert,et al.  Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically "nonresponsive" to other aromatic hydrocarbons. , 1974, The Journal of biological chemistry.

[4]  Y. Fujii‐Kuriyama,et al.  A complete structure of the mouse Ah receptor gene. , 1994, Pharmacogenetics.

[5]  A Poland,et al.  2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. , 1982, Annual review of pharmacology and toxicology.

[6]  H. Swanson,et al.  The AH-receptor: genetics, structure and function. , 1993, Pharmacogenetics.

[7]  E. Southern,et al.  DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale. , 1996, Trends in genetics : TIG.

[8]  J. Wetmur.  DNA probes: applications of the principles of nucleic acid hybridization. , 1991, Critical reviews in biochemistry and molecular biology.

[9]  N P Wray,et al.  Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes. , 1982, Cancer research.

[10]  M. Kuo,et al.  Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system. , 1995, Biochemical pharmacology.

[11]  C. Miller,et al.  CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. , 1993, Carcinogenesis.

[12]  H. Swanson,et al.  Cloning and expression of a human Ah receptor cDNA. , 1993, Molecular pharmacology.

[13]  B. Taylor,et al.  The murine Ah locus: a new allele and mapping to chromosome 12. , 1987, Molecular pharmacology.

[14]  Y Fujii-Kuriyama,et al.  Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. , 1994, The Journal of biological chemistry.

[15]  P. Harper,et al.  Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. , 1989, Molecular pharmacology.

[16]  Y. Fujii‐Kuriyama,et al.  A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt. , 1993, The Journal of biological chemistry.

[17]  L. Poellinger,et al.  Purification of the DNA binding form of dioxin receptor. Role of the Arnt cofactor in regulation of dioxin receptor function. , 1994, The Journal of biological chemistry.

[18]  K. Itakura,et al.  Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[19]  J. Gustafsson,et al.  Human dioxin receptor chimera transactivation in a yeast model system and studies on receptor agonists and antagonists. , 1995, Pharmacology & toxicology.

[20]  D W Nebert,et al.  The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. , 1989, Critical reviews in toxicology.

[21]  O. Gotoh,et al.  cDNA cloning and structure of mouse putative Ah receptor. , 1992, Biochemical and biophysical research communications.

[22]  H. Erlich,et al.  A method for typing polymorphism at the HLA-A locus using PCR amplification and immobilized oligonucleotide probes. , 1994, Tissue antigens.

[23]  D. Smith,et al.  Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. , 1993, Pharmacogenetics.

[24]  C. Kiyohara,et al.  Polymorphisms of human Ah receptor gene are not involved in lung cancer. , 1995, Pharmacogenetics.

[25]  V. Vasiliou,et al.  Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction a , 1993, Annals of the New York Academy of Sciences.

[26]  E. Glover,et al.  Analysis of the four alleles of the murine aryl hydrocarbon receptor. , 1994, Molecular pharmacology.

[27]  T. Kamataki,et al.  Characterization of Ah receptor promoter in human liver cell line, HepG2. , 1994, Pharmacogenetics.

[28]  A. Mirzabekov,et al.  Sequence analysis by hybridization with oligonucleotide microchip: identification of beta-thalassemia mutations. , 1997, Gene.

[29]  A. Okey,et al.  Binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to AH receptor in placentas from normal versus abnormal pregnancy outcomes. , 1997, Chemosphere.

[30]  S. P. Fodor,et al.  Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two–colour fluorescence analysis , 1996, Nature Genetics.

[31]  E. Glover,et al.  Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. , 1976, The Journal of biological chemistry.

[32]  C R Shaw,et al.  Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. , 1973, The New England journal of medicine.

[33]  Y. Fujii‐Kuriyama,et al.  Regulation of Dioxin Receptor Function by Omeprazole* , 1997, The Journal of Biological Chemistry.

[34]  P. Harper,et al.  Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. , 1991, Molecular pharmacology.

[35]  C. Bradfield,et al.  The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system. , 1994, The Journal of biological chemistry.

[36]  A. Puga,et al.  Constitutive Activation of the Aromatic Hydrocarbon Receptor , 1998, Molecular and Cellular Biology.

[37]  P. Harper,et al.  Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line. , 1988, Cancer research.

[38]  D. Nebert,et al.  Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance. , 1997, Critical reviews in toxicology.

[39]  R. Glass,et al.  Frontometaphyseal dysplasia: neonatal radiographic diagnosis. , 1995, American journal of medical genetics.

[40]  D. Nebert,et al.  Induction of Aryl Hydrocarbon Hydroxylase Activity in Various Cell Cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin , 1975 .

[41]  C. Bradfield,et al.  Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. , 1993, The Journal of biological chemistry.

[42]  D. Nebert,et al.  Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. , 1997, Pharmacogenetics (London).

[43]  C. Bradfield,et al.  Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[44]  Jennifer V. Schmidt,et al.  Molecular Characterization of the Murine Ahr Gene , 1993 .

[45]  Hana R. Phol.  Toxicological profile for chlorinated dibenzo-p-dioxins , 1998 .