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[1] P. Bork,et al. Linear Motif Atlas for Phosphorylation-Dependent Signaling , 2008, Science Signaling.
[2] Christian von Mering,et al. STITCH: interaction networks of chemicals and proteins , 2007, Nucleic Acids Res..
[3] Allegra Via,et al. Phospho.ELM: a database of phosphorylation sites—update 2008 , 2007, Nucleic Acids Res..
[4] F. White,et al. Uncovering Therapeutic Targets FOR Glioblastoma: A Systems Biology Approach , 2007, Cell cycle.
[5] K. Gunsalus,et al. Network modeling links breast cancer susceptibility and centrosome dysfunction. , 2007, Nature genetics.
[6] T. Ideker,et al. Network-based classification of breast cancer metastasis , 2007, Molecular systems biology.
[7] Keith L. Ligon,et al. Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies , 2007, Science.
[8] A. Barabasi,et al. Drug—target network , 2007, Nature Biotechnology.
[9] M. Mann,et al. Is Proteomics the New Genomics? , 2007, Cell.
[10] Douglas A. Lauffenburger,et al. Common effector processing mediates cell-specific responses to stimuli , 2007, Nature.
[11] Forest M White,et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma , 2007, Proceedings of the National Academy of Sciences.
[12] P. Bork,et al. Systematic Discovery of In Vivo Phosphorylation Networks , 2007, Cell.
[13] C. Bakal,et al. Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology , 2007, Science.
[14] Eric S. Lander,et al. Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene , 2007, Cell.
[15] W. Lim,et al. Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors , 2007, Nature.
[16] A. Barabasi,et al. The human disease network , 2007, Proceedings of the National Academy of Sciences.
[17] D. Lauffenburger,et al. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks , 2007, Proceedings of the National Academy of Sciences.
[18] Michael B Yaffe,et al. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. , 2007, Cancer cell.
[19] N. Shah,et al. Projecting future drug expenditures--2007. , 2007, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
[20] Joseph A DiMasi,et al. Economics of new oncology drug development. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[21] Forest M. White,et al. Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data , 2006, PLoS Comput. Biol..
[22] Christian von Mering,et al. STRING 7—recent developments in the integration and prediction of protein interactions , 2006, Nucleic Acids Res..
[23] M. Mann,et al. Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks , 2006, Cell.
[24] Ricardo Paxson,et al. Model-based design approaches in drug discovery: A parallel to traditional engineering approaches , 2006, IBM J. Res. Dev..
[25] Michael B. Yaffe,et al. Data-driven modelling of signal-transduction networks , 2006, Nature Reviews Molecular Cell Biology.
[26] Sampsa Hautaniemi,et al. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration , 2006, Molecular systems biology.
[27] Alastair J J Wood,et al. A proposal for radical changes in the drug-approval process. , 2006, The New England journal of medicine.
[28] T. Pawson,et al. Reading protein modifications with interaction domains , 2006, Nature Reviews Molecular Cell Biology.
[29] J. Reichert. Trends in US approvals: new biopharmaceuticals and vaccines , 2006, Trends in Biotechnology.
[30] P. Bork,et al. Proteome survey reveals modularity of the yeast cell machinery , 2006, Nature.
[31] Sean R. Collins,et al. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae , 2006, Nature.
[32] N. Powe,et al. Are development times for pharmaceuticals increasing or decreasing? , 2006, Health affairs.
[33] Henry G. Grabowski,et al. The quantity and quality of worldwide new drug introductions, 1982-2003. , 2006, Health affairs.
[34] K. Hunter,et al. Mapping normal and cancer cell signalling networks: towards single-cell proteomics , 2006 .
[35] D. Lauffenburger,et al. A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis , 2005, Science.
[36] S. L. Wong,et al. Towards a proteome-scale map of the human protein–protein interaction network , 2005, Nature.
[37] D. Lauffenburger,et al. A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates , 2005, Nature Methods.
[38] Tony Pawson,et al. Synthetic modular systems – reverse engineering of signal transduction , 2005, FEBS letters.
[39] Natasa Przulj,et al. High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells , 2005, Science.
[40] M. Mann,et al. Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics , 2004, Nature Biotechnology.
[41] Jonathan M Irish,et al. Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells , 2004, Cell.
[42] Tony Pawson,et al. Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[43] Janice M. Reichert,et al. A guide to drug discovery: Trends in development and approval times for new therapeutics in the United States , 2003, Nature Reviews Drug Discovery.
[44] E. Triphosphat,et al. FEBS Letters , 1987, FEBS Letters.
[45] M. DePamphilis,et al. HUMAN DISEASE , 1957, The Ulster Medical Journal.