Synthesis of 6-Aminopropyl-6H-indolo[2,3-b]quinoxaline Derivatives

A series of 6-(3-aminopropyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields by the reaction of 6-(3-chloropropyl)-6H-indolo[2,3-b]quinoxaline and corresponding amines in presence of tetrabutylammonium iodide in boiling toluene or dimethylformamide at room temperature. It was found that boiling of 6-(3-chloropropyl)-6H-indolo[2,3-b]quinoxaline in acetone with sodium iodide or in acetic acid lead to intramolecular cyclization product.

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