Memory consolidation and NMDA receptors: discrepancy between genetic and pharmacological approaches.

Using third-generation molecular engineering techniques, Shimizu et al . ([1][1]) claimed that inducible targeted deletion of the N -methyl-d-aspartate (NMDA) NR1 receptor gene in area CA1 of the hippocampus interferes with memory consolidation for two hippocampus-dependent learning tasks. Although

[1]  B. McNaughton,et al.  Reactivation of hippocampal ensemble memories during sleep. , 1994, Science.

[2]  Joe Z Tsien,et al.  Linking Hebb’s coincidence-detection to memory formation , 2000, Current Opinion in Neurobiology.

[3]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[4]  G. Lynch,et al.  Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5 , 1986, Nature.

[5]  T. Salt,et al.  Mediation of thalamic sensory input by both NMDA receptors and non-NMDA receptors , 1986, Nature.

[6]  David J. Anderson,et al.  Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain , 1996, Cell.

[7]  R. Morris Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5 , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[8]  J. Ashby References and Notes , 1999 .

[9]  Ian Q. Whishaw,et al.  A comparison of rats and mice in a swimming pool place task and matching to place task: Some surprising differences , 1995, Physiology & Behavior.

[10]  M. Gallagher,et al.  Behavioral effects of MK-801 mimic deficits associated with hippocampal damage , 1989, Psychobiology.

[11]  L. Squire,et al.  Retrograde amnesia and memory consolidation: a neurobiological perspective , 1995, Current Opinion in Neurobiology.

[12]  T. Teyler,et al.  Long-term potentiation. , 1987, Annual review of neuroscience.

[13]  E. Hargreaves,et al.  An examination of the relations between hippocampal long‐term potentiation, kindling, afterdischarge, and place learning in the water maze , 1993, Hippocampus.

[14]  J. D. McGaugh Memory--a century of consolidation. , 2000, Science.

[15]  Eliot Slater Psychobiology , 1949 .

[16]  E. Shimizu,et al.  NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. , 2000, Science.

[17]  C. H. Vanderwolf,et al.  Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: nonspatial pretraining eliminates spatial learning deficits. , 1996, Behavioral neuroscience.

[18]  S. J. Martin,et al.  Reversible neural inactivation reveals hippocampal participation in several memory processes , 1999, Nature Neuroscience.

[19]  D. Cain,et al.  Spatial learning without NMDA receptor-dependent long-term potentiation , 1995, Nature.

[20]  Ian Q Whishaw,et al.  Of Mice and Mazes: Similarities Between Mice and Rats on Dry Land But Not Water Mazes , 1996, Physiology & Behavior.

[21]  B. McNaughton,et al.  Memory reprocessing in corticocortical and hippocampocortical neuronal ensembles. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[22]  T. Yagi,et al.  Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit , 1995, Nature.

[23]  M. Wilson,et al.  Temporally Structured Replay of Awake Hippocampal Ensemble Activity during Rapid Eye Movement Sleep , 2001, Neuron.

[24]  J. Hall,et al.  Detailed behavioral analysis of water maze acquisition under APV or CNQX: contribution of sensorimotor disturbances to drug-induced acquisition deficits. , 1996, Behavioral neuroscience.

[25]  D. Wilkin,et al.  Neuron , 2001, Brain Research.

[26]  Bryan Kolb,et al.  A cautionary note regarding drug and brain lesion studies that use swimming pool tasks: partial reinforcement impairs acquisition of place learning in a swimming pool but not on dry land , 2000, Behavioural Brain Research.