Untargeted LC‐MS‐based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, &bgr;‐oxidation of fatty acids and the TCA cycle in male mice

[1]  David S. Wishart,et al.  MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis , 2018, Nucleic Acids Res..

[2]  W. Liu,et al.  Di(2-ethylhexyl)phthalate Alters the Synthesis and β-Oxidation of Fatty Acids and Hinders ATP Supply in Mouse Testes via UPLC-Q-Exactive Orbitrap MS-Based Metabonomics Study. , 2017, Journal of agricultural and food chemistry.

[3]  Seoul Lee,et al.  Aristolochic Acid I Causes Testis Toxicity by Inhibiting Akt and ERK1/2 Phosphorylation. , 2016, Chemical research in toxicology.

[4]  A. Ferramosca,et al.  Bioenergetics of Mammalian Sperm Capacitation , 2014, BioMed research international.

[5]  P. Moschou,et al.  Polyamines and programmed cell death. , 2014, Journal of experimental botany.

[6]  Christian M. Metallo,et al.  Understanding metabolic regulation and its influence on cell physiology. , 2013, Molecular cell.

[7]  K. Rosendal,et al.  Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa , 2011, Human reproduction.

[8]  B. Murphy,et al.  Polyamines on the reproductive landscape. , 2011, Endocrine reviews.

[9]  L. Kucharski,et al.  The effect of dehydroepiandrosterone (DHEA) on renal function and metabolism in diabetic rats , 2011, Steroids.

[10]  M. Legiša,et al.  Evolution of Allosteric Citrate Binding Sites on 6-phosphofructo-1-kinase , 2010, PloS one.

[11]  David S. Goodsell,et al.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility , 2009, J. Comput. Chem..

[12]  M. Hogarty,et al.  Disrupting Polyamine Homeostasis as a Therapeutic Strategy for Neuroblastoma , 2009, Clinical Cancer Research.

[13]  J. Ruberte,et al.  Phosphofructo-1-Kinase Deficiency Leads to a Severe Cardiac and Hematological Disorder in Addition to Skeletal Muscle Glycogenosis , 2009, PLoS genetics.

[14]  Arthur J. Olson,et al.  AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..

[15]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[16]  A. Bonen,et al.  Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview , 2008, Acta physiologica.

[17]  C. Decaestecker,et al.  Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation. , 2008, Kidney international.

[18]  G. Cole,et al.  Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.

[19]  Nihal Ahmad,et al.  Dose translation from animal to human studies revisited , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  A. Bonen,et al.  Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence. , 2007, Physiology.

[21]  B. Aronow,et al.  Activation of a novel long-chain free fatty acid generation and export system in mitochondria of diabetic rat hearts. , 2006, American journal of physiology. Cell physiology.

[22]  H. Ostrer,et al.  IMMUNOLOCALIZATION OF ANDROGEN RECEPTOR AND ESTROGEN RECEPTORS α AND β IN HUMAN FETAL TESTIS AND EPIDIDYMIS , 2005 .

[23]  R. Lin,et al.  Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells. , 2005, Kidney international.

[24]  Graham M Lord,et al.  DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy. , 2004, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[25]  D. Mozaffarian,et al.  Dietary intake of trans fatty acids and systemic inflammation in women. , 2004, The American journal of clinical nutrition.

[26]  Liping Xu,et al.  Role of mitochondrial cytochrome c in cocaine-induced apoptosis in rat testes. , 2003, Urology.

[27]  C. Vervaet,et al.  Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure. , 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[28]  G. de Rosa,et al.  De novo expression of uncoupling protein 3 is associated to enhanced mitochondrial thioesterase‐1 expression and fatty acid metabolism in liver of fenofibrate‐treated rats , 2002, FEBS letters.

[29]  M. Kitazawa,et al.  Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. , 2002, The Journal of pharmacology and experimental therapeutics.

[30]  P. Ping,et al.  Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. , 2002, Circulation research.

[31]  I. Salmon,et al.  Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. , 2002, Journal of the American Society of Nephrology : JASN.

[32]  M. Gregory,et al.  Is "Chinese herbs nephropathy" a prejudicial term? , 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[33]  J. Clapham,et al.  Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice. , 2001, Biochemical and biophysical research communications.

[34]  J. Clapham,et al.  Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA. , 2001, Biochemical and biophysical research communications.

[35]  R. Lenski,et al.  Rapid phenotypic change and diversification of a soil bacterium during 1000 generations of experimental evolution. , 2001, Microbiology.

[36]  M V Lobo,et al.  Immunohistochemical Localization of Taurine in the Male Reproductive Organs of the Rat , 2000, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[37]  F. Kamp,et al.  How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? , 1999, Diabetes.

[38]  J. Squifflet,et al.  Urothelial lesions in Chinese-herb nephropathy. , 1999, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[39]  A. Bartke,et al.  Pituitary and testicular function in growth hormone receptor gene knockout mice. , 1999, Endocrinology.

[40]  M F Sanner,et al.  Python: a programming language for software integration and development. , 1999, Journal of molecular graphics & modelling.

[41]  A. Kudo,et al.  Immunohistochemical localization of androgen receptor in mouse testicular germ cells during fetal and postnatal development , 1996, The Anatomical record.

[42]  R. Hänsel,et al.  Adverse Effects of Herbal Drugs , 1993, Adverse Effects of Herbal Drugs.

[43]  D. Yandell,et al.  Single strand conformation polymorphism analysis of androgen receptor gene mutations in patients with androgen insensitivity syndromes: application for diagnosis, genetic counseling, and therapy. , 1993, The Journal of clinical endocrinology and metabolism.

[44]  M. Jadoul,et al.  Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs , 1993, The Lancet.

[45]  J. Bristow,et al.  Regulation of adult and fetal myocardial phosphofructokinase. Relief of cooperativity and competition between fructose 2,6-bisphosphate, ATP, and citrate. , 1987, The Journal of biological chemistry.

[46]  U. Mengs,et al.  Acute toxicity of aristolochic acid in rodents , 1987, Archives of Toxicology.

[47]  R. Aitken,et al.  A prospective study of the relationship between semen quality and fertility in cases of unexplained infertility. , 1984, Journal of andrology.

[48]  J. Lowenstein,et al.  Control of phosphofructokinase from rat skeletal muscle. Effects of fructose diphosphate, AMP, ATP, and citrate. , 1976, The Journal of biological chemistry.

[49]  Ben-Yang Liao Expression Evolution of Mammalian Genes. , 2008 .

[50]  Hu Jian-min Effects of Taurine on Testosterone Secretion and Its Mechanism , 2006 .

[51]  Liu Yan-ming Active Change of CaN in Artery Smooth Muscle Cell and Na~+-K~+-ATPase in Myocardic with Spontaneous Hypertension , 2005 .

[52]  J. Cosyns Aristolochic Acid and ‘Chinese Herbs Nephropathy’ , 2003, Drug safety.

[53]  Z. Jian Structure analysis and feature research of aristolochic acid , 2003 .

[54]  Zhou Shi-zhen Determination of Aristolochic Acid A in Decoction of Caulis Aristolochiae Manshuriensis by RP-HPLC , 2002 .

[55]  J. Regadera,et al.  Androgen receptor expression in sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis. , 2001, The Journal of clinical endocrinology and metabolism.

[56]  R. Mrsny,et al.  TAURINE AND HYPOTAURINE: THEIR EFFECTS ON MOTILITY, CAPACITATION AND THE ACROSOME REACTION OF HAMSTER SPERM IN VITRO AND THEIR PRESENCE IN SPERM AND REPRODUCTIVE TRACT FLUIDS OF SEVERAL MAMMALS * , 1980, Development, growth & differentiation.

[57]  G. Biomembrane ON THE BINDING OF SUCCINATE DEHYDROGENASE TO MITOCHONDRIAL INNER MEMBRANE , 1976 .