A review from patents inspired by the genus Cannabis

Specialized or secondary metabolism of plants from the genus Cannabis has been widely studied, generating a huge investment in research and development of patents. This review highlights the most recent patents granted so far, with some exceptions, covering different areas of knowledge including biotechnological aspects of plant specialized/secondary metabolism. Several patent databases were consulted in order to collect patent information. There are patents for specialized/secondary metabolite isolation methods, synthesis, production, genes, development of medicaments, drug delivery systems, equipment, machines, industrial processes, plant culture techniques, improved plant varieties, among others. Furthermore, important aspects such as nutrition and fiber production having unlimited applications in several areas are discussed. Endocannabinoid system is a special topic that has been included in this review due to interconnections among cannabinoids, endocannabinoids and its medical effects in human beings. This review of the state-of-the-art about Cannabis patents has the potential to be a valuable source of organized information for those researchers developing projects in many aspects related to this important natural resource.

[1]  Chas. L. Ashley The Treatment of Cough , 1906, Medicina, cirurgia, farmacia.

[2]  徐诚 Hemp/silkworm (kiginu) silk high-count blended knitted fabric and manufacturing method thereof , 2010 .

[3]  D. Marasco,et al.  Phytocannabinoids and Cannabimimetic Drugs: Recent Patents in Central Nervous System Disorders. , 2016, Recent patents on CNS drug discovery.

[4]  S. Montserrat-de la Paz,et al.  Hemp ( Cannabis sativa L.) seed oil: analytical and phytochemical characterization of the unsaponifiable fraction. , 2014, Journal of agricultural and food chemistry.

[5]  J. Callaway Hempseed as a nutritional resource: An overview , 2004, Euphytica.

[6]  R. Tiwari,et al.  Drug delivery systems: An updated review , 2012, International journal of pharmaceutical investigation.

[7]  리터 도리스,et al.  Compounds which modulate the cb2 receptor , 2007 .

[8]  David T. Brown Cannabis: The Genus Cannabis , 1998 .

[9]  가르존아아론,et al.  Agonists specific for the peripheral cannabinoid receptor , 2000 .

[10]  E. Small A Numerical and Nomenclatural Analysis of Morpho-Geographic Taxa of Humulus , 1978 .

[11]  W. Davies The chemistry of milk , 1936 .

[12]  Gianpietro Venturi,et al.  Hemp as a raw material for industrial applications , 2004, Euphytica.

[13]  M. Cascio,et al.  Biosynthesis and Fate of Endocannabinoids. , 2015, Handbook of experimental pharmacology.

[14]  P. Dewick,et al.  Medicinal Natural Products: A Biosynthetic Approach , 1997 .

[15]  A. Gomtsyan,et al.  TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats , 2015, Temperature.

[16]  D. Deutsch,et al.  Inhibition of Fatty Acid Binding Proteins Elevates Brain Anandamide Levels and Produces Analgesia , 2014, PloS one.

[17]  ORAL DETECTION TEST FOR CANNABINOID USE , 2017 .

[18]  고토 미카,et al.  Cannabinoid receptor modulator , 2004 .

[19]  Махамауд А. Элсоли,et al.  Method for preparing delta-9-tetrahydrocannabinol esters , 1999 .

[20]  R. Verpoorte,et al.  Methods for the analysis of cannabinoids in biological materials: a review. , 2004, Phytochemical analysis : PCA.

[21]  赵华伟,et al.  Preparation method and application of China hemp fiber , 2013 .

[22]  R. Pertwee Endocannabinoids and Their Pharmacological Actions. , 2015, Handbook of experimental pharmacology.

[23]  P. Murumkar,et al.  A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents , 2015, Expert opinion on therapeutic patents.

[24]  Jan Ludlow METHOD OF PREPARING DELTA-9- TETRAHYDROCANNABINOL BACKGROUND OF THE INVENTION , 2017 .

[25]  J. Breitenbucher Inhibitors of fatty acid amide hydrolase (FAAH): SAR and results in pre-clinical pain models , 2013 .

[26]  뮬러아담 Process for producing an extract from cannabis plant matter, containing a tetrahydrocannabinol and a cannabidiol and cannabis extracts , 2001 .

[27]  RECEPTOR RELATED DISEASES WITH CANNABINOID RECEPTOR LIGANDS , 2017 .

[28]  S. Wills CANNABIS USE AND ABUSE BY MAN: AN HISTORICAL PERSPECTIVE , 1998 .

[29]  康红梅,et al.  Improved variety breeding technology for industrial cannabis sativa L. , 2013 .

[30]  S. Dey,et al.  Endocannabinoid signaling at the periphery: 50 years after THC. , 2015, Trends in pharmacological sciences.

[31]  D. Deutsch,et al.  Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)* , 2015, The Journal of Biological Chemistry.

[32]  Мартин Питер Кроппер,et al.  Antiperspirant or deodorant compositions , 2005 .

[33]  M. Zenk,et al.  Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol , 1998, FEBS letters.

[34]  M. Wink Medicinal Natural Products. A Biosynthetic Approach , 2002 .

[35]  赵华伟 Hemp stem viscose fiber sanitary towel and preparation method thereof , 2012 .

[36]  P. Cullis,et al.  Drug Delivery Systems: Entering the Mainstream , 2004, Science.

[37]  Emilio Rodríguez-Cerezo,et al.  Analysing patent landscapes in plant biotechnology and new plant breeding techniques , 2012, Transgenic Research.

[38]  Bethesda,et al.  Cannabinoids as antioxidants and neuroprotectants , 2011 .

[39]  P. Robson,et al.  The Medicinal Uses of Cannabis and Cannabinoids , 2008 .

[40]  P. Thanos,et al.  Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms , 2015, Molecular pain.

[41]  Kathleen L. Hefferon,et al.  Nutritionally Enhanced Food Crops; Progress and Perspectives , 2015, International journal of molecular sciences.

[42]  E. Small Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization , 2015, The Botanical Review.

[43]  K. Müller-Vahl,et al.  The therapeutic potential of cannabis and cannabinoids. , 2012, Deutsches Arzteblatt international.

[44]  A. Zuardi History of cannabis as a medicine: a review. , 2006, Revista brasileira de psiquiatria.

[45]  ダート,マイケル・ジエイ,et al.  Compounds that are cannabinoid receptor ligands , 2010 .

[46]  M. L. Gerra,et al.  Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists. , 2010, Recent patents on CNS drug discovery.

[47]  李惠森 Ultrasonic assisted supercritical CO2 hemp seed oil extraction method , 2012 .

[48]  刘瑞宁 Enzyme oxidation pre-processing technology for hemp fabric , 2010 .

[49]  K. Hefferon Plant biotechnology patents: applications in agriculture and medicine. , 2010, Recent patents on biotechnology.

[50]  S. Morimoto,et al.  Purification and characterization of cannabichromenic acid synthase from Cannabis sativa. , 1998, Phytochemistry.

[51]  H. Lou,et al.  Characterization of Lignanamides from Hemp (Cannabis sativa L.) Seed and Their Antioxidant and Acetylcholinesterase Inhibitory Activities. , 2015, Journal of agricultural and food chemistry.

[52]  R. Witkamp The Endocannabinoid System: A Dynamic Signalling System at the Crossroads Between Metabolism and Disease , 2014 .

[53]  C. Andre,et al.  Cannabis sativa: The Plant of the Thousand and One Molecules , 2016, Front. Plant Sci..

[54]  R. Verpoorte,et al.  Secondary metabolism in cannabis , 2008, Phytochemistry Reviews.

[55]  威廉·W·托德 Cannabis drug delivery and monitoring system , 2011 .

[56]  M. Maccarrone,et al.  The endocannabinoid system: an overview , 2011, Front. Behav. Neurosci..

[57]  C. Brenner Intellectual Property Rights and Technology Transfer in Developing Country Agriculture: Rhetoric and Reality , 1998 .

[58]  刘国忠,et al.  Manufacturing method of bast fiber nonwoven fabric , 2008 .

[59]  A. Persidis Agricultural biotechnology , 1991, Nature Biotechnology.

[60]  M. Mor,et al.  Fatty acid amide hydrolase inhibitors: a patent review (2009 – 2014) , 2015, Expert opinion on therapeutic patents.

[61]  R. Cook-Deegan,et al.  After Myriad: Genetic Testing in the Wake of Recent Supreme Court Decisions about Gene Patents , 2014, Current Genetic Medicine Reports.

[62]  휘틀 브라이언앤쏘니 Cannabinoid liquid formulations for mucosal administration , 2003 .

[63]  季国苗 China hemp and cotton mixed fiber fabric , 2010 .

[64]  S. Gaetani,et al.  Modulation of anxiety through blockade of anandamide hydrolysis , 2003, Nature Medicine.

[65]  E. Heerdink,et al.  The prevalence and incidence of medicinal cannabis on prescription in The Netherlands , 2013, European Journal of Clinical Pharmacology.

[66]  S. Davis,et al.  Endocannabinoid system overactivity and the metabolic syndrome: Prospects for treatment , 2008, Current diabetes reports.

[67]  B. Hawes,et al.  Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells , 2008, British journal of pharmacology.

[68]  张建春,et al.  Hemp knitting face fabric , 2009 .

[69]  S. Morimoto,et al.  Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes. , 2005, Plant & cell physiology.