Somatostatin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
暂无分享,去创建一个
D. Hoyer | S. Schulz | S. Melmed | A. Harmar | A. Vezzani | W. Meyerhof | Z. Csaba | P. Dournaud | J. Reubi | L. Hofland | T. Reisine | H. Wester | J. Castaño | J. Epelbaum | A. O'Carroll | M. Schindler | John E. Taylor | A. Lupp | A. Schonbrunn | H. Schmid | Y. Patel | W. Feniuk | P. Humphrey | R. Hills | H. Kreienkamp | G. Tulipano | Corinne Bosquet | M. Culler
[1] M. Korbonits,et al. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature , 2018, Pharmacological Reviews.
[2] S. Schulz,et al. Phosphorylation of threonine 333 regulates trafficking of the human sst5 somatostatin receptor. , 2013, Molecular endocrinology.
[3] S. Schulz,et al. Correlation of monoclonal and polyclonal somatostatin receptor 5 antibodies in pancreatic neuroendocrine tumors. , 2013, International journal of clinical and experimental pathology.
[4] S. Schulz,et al. Reassessment of sst3 Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-5 , 2012, Neuroendocrinology.
[5] A. Colao,et al. A 12-month phase 3 study of pasireotide in Cushing's disease. , 2012, The New England journal of medicine.
[6] D. Treit,et al. The anxiolytic effects of somatostatin following intra-septal and intra-amygdalar microinfusions are reversed by the selective sst2 antagonist PRL2903 , 2012, Pharmacology Biochemistry and Behavior.
[7] H. M. Morris,et al. Lamina- and cell-specific alterations in cortical somatostatin receptor 2 mRNA expression in schizophrenia , 2012, Neuropharmacology.
[8] M. Buchfelder,et al. DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours. , 2012, European journal of endocrinology.
[9] S. Lamberts,et al. Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy , 2012, Journal of Endocrinological Investigation.
[10] S. Schulz,et al. A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K Pathway , 2011, Molecular and Cellular Biology.
[11] E. Sztul,et al. Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3. , 2011, Biochemical and biophysical research communications.
[12] Wolfgang A Weber,et al. PET of Somatostatin Receptor–Positive Tumors Using 64Cu- and 68Ga-Somatostatin Antagonists: The Chelate Makes the Difference , 2011, The Journal of Nuclear Medicine.
[13] J. Reubi,et al. Somatostatin Receptors as Targets for Nuclear Medicine Imaging and Radionuclide Treatment , 2011, The Journal of Nuclear Medicine.
[14] J. Brandner,et al. Somatostatin Inhibits Cell Migration and Reduces Cell Counts of Human Keratinocytes and Delays Epidermal Wound Healing in an Ex Vivo Wound Model , 2011, PloS one.
[15] M. Ghosh,et al. Ligand-dependent mechanisms of sst2A receptor trafficking: role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists. , 2011, Molecular endocrinology.
[16] M. Ghosh,et al. Differential Temporal and Spatial Regulation of Somatostatin Receptor Phosphorylation and Dephosphorylation* , 2011, The Journal of Biological Chemistry.
[17] K. Jurkschat,et al. One-step ¹⁸F-labeling of carbohydrate-conjugated octreotate-derivatives containing a silicon-fluoride-acceptor (SiFA): in vitro and in vivo evaluation as tumor imaging agents for positron emission tomography (PET). , 2010, Bioconjugate chemistry.
[18] J. Kittilson,et al. Rainbow trout somatostatin receptor subtypes SSTR1A, SSTR1B, and SSTR2 differentially activate the extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling pathways in transfected cells. , 2010, Journal of molecular endocrinology.
[19] J. Reubi,et al. Radiolabeled Bicyclic Somatostatin-Based Analogs: A Novel Class of Potential Radiotracers for SPECT/PET of Neuroendocrine Tumors , 2010, The Journal of Nuclear Medicine.
[20] D. Corella,et al. The rs1466113 Polymorphism in the Somatostatin Receptor 2 Gene Is Associated with Obesity and Food Intake in a Mediterranean Population , 2010, Annals of Nutrition and Metabolism.
[21] Lei Wang,et al. Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats. , 2010, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[22] E. Christ,et al. Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients. , 2010, The Journal of clinical endocrinology and metabolism.
[23] J. Epelbaum,et al. Somatostatin Contributes to In Vivo Gamma Oscillation Modulation and Odor Discrimination in the Olfactory Bulb , 2010, The Journal of Neuroscience.
[24] M. Buchfelder,et al. The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells. , 2010, Cancer research.
[25] J. Rivier,et al. Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways. , 2010, Molecular endocrinology.
[26] A. Faggiano,et al. Somatostatin analogues: treatment of pituitary and neuroendocrine tumors. , 2010, Progress in brain research.
[27] M. Culler,et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. , 2009, American journal of physiology. Endocrinology and metabolism.
[28] P. Rochaix,et al. Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer , 2009, Proceedings of the National Academy of Sciences.
[29] C. Schade-Brittinger,et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[30] S. Schulz,et al. Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors. , 2009, The Journal of clinical endocrinology and metabolism.
[31] A. Schonbrunn,et al. Site Specificity of Agonist and Second Messenger-Activated Kinases for Somatostatin Receptor Subtype 2A (Sst2A) Phosphorylation , 2009, Molecular Pharmacology.
[32] J. Reubi,et al. Highly Efficient In Vivo Agonist-Induced Internalization of sst2 Receptors in Somatostatin Target Tissues , 2009, Journal of Nuclear Medicine.
[33] C. Verney,et al. The Somatostatin 2A Receptor Is Enriched in Migrating Neurons during Rat and Human Brain Development and Stimulates Migration and Axonal Outgrowth , 2009, PloS one.
[34] S. Schulz,et al. Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro. , 2009, The Journal of clinical endocrinology and metabolism.
[35] S. Schulz,et al. Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions , 2009, FEBS letters.
[36] D. Figarella-Branger,et al. Somatostatin receptor sst2 decreases cell viability and hormonal hypersecretion and reverses octreotide resistance of human pituitary adenomas. , 2008, Cancer research.
[37] S. Najib,et al. Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1 , 2008, Cellular and Molecular Life Sciences.
[38] M. Culler,et al. Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2. , 2008, Endocrinology.
[39] Jean E Rivier,et al. Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. , 2008, Journal of medicinal chemistry.
[40] F. Lopez,et al. Identification of an upstream promoter of the human somatostatin receptor, hSSTR2, which is controlled by epigenetic modifications. , 2008, Endocrinology.
[41] M. Culler,et al. Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. , 2008, Endocrine-related cancer.
[42] M. Strowski,et al. Function and expression of somatostatin receptors of the endocrine pancreas , 2008, Molecular and Cellular Endocrinology.
[43] M. Buchfelder,et al. Selective loss of somatostatin receptor 2 in octreotide-resistant growth hormone-secreting adenomas. , 2008, The Journal of clinical endocrinology and metabolism.
[44] S. Schulz,et al. New Pansomatostatin Ligands and Their Chelated Versions: Affinity Profile, Agonist Activity, Internalization, and Tumor Targeting , 2008, Clinical Cancer Research.
[45] S. Schulz,et al. Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[46] I. Sauer,et al. Somatostatin receptor subtype-2-deficient mice with diet-induced obesity have hyperglycemia, nonfasting hyperglucagonemia, and decreased hepatic glycogen deposition. , 2007, Endocrinology.
[47] P. Bagnoli,et al. Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice. , 2007, Investigative ophthalmology & visual science.
[48] H. Parkington,et al. Somatostatin decreases voltage-gated Ca2+ currents in GH3 cells through activation of somatostatin receptor 2. , 2007, American journal of physiology. Endocrinology and metabolism.
[49] A. Balbarini,et al. Expression, pharmacology, and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages , 2007, Journal of leukocyte biology.
[50] B. Wiedenmann,et al. Characterization of somatostatin receptor subtype-specific regulation of insulin and glucagon secretion: an in vitro study on isolated human pancreatic islets. , 2007, The Journal of clinical endocrinology and metabolism.
[51] D. lattuada,et al. Inhibitory effect of pasireotide and octreotide on lymphocyte activation , 2007, Journal of Neuroimmunology.
[52] R. Baum,et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? , 2007, European Journal of Nuclear Medicine and Molecular Imaging.
[53] Frédéric Lopez,et al. Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway , 2006, The EMBO journal.
[54] A. Bottoni,et al. Role of complex cyclin d1/cdk4 in somatostatin subtype 2 receptor-mediated inhibition of cell proliferation of a medullary thyroid carcinoma cell line in vitro. , 2006, Endocrinology.
[55] U. Pagotto,et al. Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression. , 2006, Cancer research.
[56] B. Bernard,et al. [(99m)Tc]Demotate 2 in the detection of sst(2)-positive tumours: a preclinical comparison with [(111)In]DOTA-tate. , 2006, European journal of nuclear medicine and molecular imaging.
[57] Y. Wong,et al. Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src. , 2005, The Journal of biological chemistry.
[58] L. Pradayrol,et al. Characterization of the bystander effect of somatostatin receptor sst2 after in vivo gene transfer into human pancreatic cancer cells. , 2005, Human gene therapy.
[59] J. Rivier,et al. Receptor Signaling and Endocytosis Are Differentially Regulated by Somatostatin Analogs , 2005, Molecular Pharmacology.
[60] S. Yibchok-anun,et al. Somatostatin Increases Phospholipase D Activity and Phosphatidylinositol 4,5-bisphosphate Synthesis in Clonal β Cells HIT-T15 , 2005, Molecular Pharmacology.
[61] P. Rochaix,et al. Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies. , 2005, European journal of endocrinology.
[62] S. Atkin,et al. Somatostatin receptors 2 and 5 are preferentially expressed in proliferating endothelium , 2005, British Journal of Cancer.
[63] Martin A Walter,et al. Preclinical evaluation of new and highly potent analogues of octreotide for predictive imaging and targeted radiotherapy. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[64] J. Rivier,et al. Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. , 2005, Journal of medicinal chemistry.
[65] Kamel El-Darwish,et al. Superagonism at the Human Somatostatin Receptor Subtype 4 , 2005, Journal of Pharmacology and Experimental Therapeutics.
[66] D. Hoyer,et al. Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. , 2005, Journal of medicinal chemistry.
[67] S. Arena,et al. Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways. , 2005, Molecular Endocrinology.
[68] M. Low. Clinical endocrinology and metabolism. The somatostatin neuroendocrine system: physiology and clinical relevance in gastrointestinal and pancreatic disorders. , 2004, Best practice & research. Clinical endocrinology & metabolism.
[69] V. Martínez,et al. Role of somatostatin receptors on gastric acid secretion in wild-type and somatostatin receptor type 2 knockout mice , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.
[70] P. Bagnoli,et al. Functional correlates of somatostatin receptor 2 overexpression in the retina of mice with genetic deletion of somatostatin receptor 1 , 2004, Brain Research.
[71] H. Schmid,et al. Functional Activity of the Multiligand Analog SOM230 at Human Recombinant Somatostatin Receptor Subtypes Supports Its Usefulness in Neuroendocrine Tumors , 2004, Neuroendocrinology.
[72] S. Atkin,et al. Inhibition of endothelial proliferation by the somatostatin analogue SOM230 , 2004, Clinical endocrinology.
[73] A. Kappeler,et al. Cellular detection of sst2A receptors in human gastrointestinal tissue , 2004, Gut.
[74] R. Murray,et al. Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. , 2004, The Journal of clinical investigation.
[75] M. Norman,et al. Deficiency of somatostatin (SST) receptor type 5 (SSTR5) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas , 2004, Molecular and Cellular Endocrinology.
[76] P. Dasgupta. Somatostatin analogues: multiple roles in cellular proliferation, neoplasia, and angiogenesis. , 2004, Pharmacology & therapeutics.
[77] C. Bousquet,et al. Molecular Signaling of Somatostatin Receptors , 2004, Annals of the New York Academy of Sciences.
[78] K. Thermos,et al. The somatostatin receptor (sst1) modulates the release of somatostatin in rat retina , 2004, Neuroscience Letters.
[79] P. Bagnoli,et al. Altered morphology of rod bipolar cell axonal terminals in the retinas of mice carrying genetic deletion of somatostatin subtype receptor 1 or 2 , 2004, The European journal of neuroscience.
[80] T. Troxler,et al. SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist. , 2004, Neuroscience letters.
[81] I. Shimon,et al. PTR-3173 (Somatoprim™), a novel somatostatin analog with affinity for somatostatin receptors 2, 4 and 5 is a potent inhibitor of human GH secretion , 2004, Journal of endocrinological investigation.
[82] J. Reubi,et al. In vivo phosphorylation of the somatostatin 2A receptor in human tumors. , 2003, The Journal of clinical endocrinology and metabolism.
[83] J. Rivier,et al. Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan. , 2003, Journal of medicinal chemistry.
[84] M. Cattaneo,et al. Anti-migratory and Anti-invasive Effect of Somatostatin in Human Neuroblastoma Cells , 2003, Journal of Biological Chemistry.
[85] A. Eychène,et al. sst2 Somatostatin Receptor Inhibits Cell Proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 Activation* , 2003, Journal of Biological Chemistry.
[86] S. Melmed,et al. Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion. , 2003, The Journal of clinical endocrinology and metabolism.
[87] Eric Vivier,et al. Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation. , 2003, Molecular biology of the cell.
[88] B. Bernard,et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals , 2003, European Journal of Nuclear Medicine and Molecular Imaging.
[89] E. Woltering. Development of targeted somatostatin-based antiangiogenic therapy: a review and future perspectives. , 2003, Cancer biotherapy & radiopharmaceuticals.
[90] J. Reubi. Peptide receptors as molecular targets for cancer diagnosis and therapy. , 2003, Endocrine reviews.
[91] K. Kendrick,et al. Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum , 2003, The European journal of neuroscience.
[92] S. Doublier,et al. Somatostatin binds to murine macrophages through two distinct subsets of receptors , 2003, Journal of Neuroimmunology.
[93] D. Coy,et al. Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats. , 2003, Diabetes.
[94] N. LaRusso,et al. Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. , 2003, American journal of physiology. Cell physiology.
[95] O. Lichtarge,et al. Conserved Motifs in Somatostatin, D2-dopamine, and α2B-Adrenergic Receptors for Inhibiting the Na-H Exchanger, NHE1* , 2003, The Journal of Biological Chemistry.
[96] D. Hoyer,et al. Agonist properties of putative small-molecule somatostatin sst2 receptor-selective antagonists. , 2003, European journal of pharmacology.
[97] D. Noonan,et al. Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities. , 2003, Endocrinology.
[98] D. Hoyer,et al. Beta(2)/beta(3)-di- and alpha/beta(3)-tetrapeptide derivatives as potent agonists at somatostatin sst(4) receptors. , 2003, Naunyn-Schmiedeberg's archives of pharmacology.
[99] H. Wilkinson,et al. Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. , 2003, Molecular endocrinology.
[100] P. Rochaix,et al. Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[101] P. Emson,et al. Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice , 2002, The Journal of comparative neurology.
[102] J. Reubi,et al. A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors. , 2002, European journal of pharmacology.
[103] S. Lamberts,et al. Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes. , 2002, American journal of physiology. Endocrinology and metabolism.
[104] L. Pradayrol,et al. Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models. , 2002, Cancer research.
[105] T. Murayama,et al. Antisecretory effect of somatostatin on gastric acid via inhibition of histamine release in isolated mouse stomach. , 2002, European journal of pharmacology.
[106] P. Dutar,et al. Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice , 2002, The European journal of neuroscience.
[107] J. Reubi,et al. NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. , 2002, Bioconjugate chemistry.
[108] D. Cocchi,et al. Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment. , 2002, Endocrinology.
[109] G. Hennig,et al. Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum. , 2002, American journal of physiology. Gastrointestinal and liver physiology.
[110] D. Hoyer,et al. Functional characterisation of the putative somatostatin sst2 receptor antagonist CYN 154806 , 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.
[111] B. Ross,et al. Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2. , 2001, Molecular endocrinology.
[112] J. Reubi,et al. Localization and characterization of neuropeptide receptors in human colon , 2001, Naunyn-Schmiedeberg's Archives of Pharmacology.
[113] P. Beck‐Peccoz,et al. Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment. , 2001, The Journal of clinical endocrinology and metabolism.
[114] P. Plas,et al. Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity. , 2001, Journal of medicinal chemistry.
[115] J. Rivier,et al. Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). , 2001, Journal of medicinal chemistry.
[116] S. Schulz,et al. Homo- and Heterodimerization of Somatostatin Receptor Subtypes , 2001, The Journal of Biological Chemistry.
[117] W. Meyerhof,et al. Agonist‐Mediated Endocytosis of Rat Somatostatin Receptor Subtype 3 Involves β‐Arrestin and Clathrin Coated Vesicles , 2001, Journal of neuroendocrinology.
[118] T. Pufe,et al. Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells. , 2001, Brain research. Molecular brain research.
[119] Xiaomin Wang,et al. Cloning and expression of a novel mouse somatostatin receptor ( SSTR 2 B ) , 2001 .
[120] Y. Wong,et al. Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C. , 2001, British journal of pharmacology.
[121] M. Schwaiger,et al. Comparison of radioiodinated TOC, TOCA and Mtr-TOCA: the effect of carbohydration on the pharmacokinetics , 2001, European Journal of Nuclear Medicine and Molecular Imaging.
[122] J. Rivier,et al. SST3-selective potent peptidic somatostatin receptor antagonists. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[123] P. Rochaix,et al. Signal transduction of somatostatin receptors negatively controlling cell proliferation , 2000, Journal of Physiology-Paris.
[124] J. Billard,et al. Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice , 2000, The European journal of neuroscience.
[125] P. Pour,et al. Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[126] A. Buchan,et al. Somatostatin receptor subtype expression and function in human vascular tissue. , 2000, American journal of physiology. Heart and circulatory physiology.
[127] J. Reubi,et al. Affinity profiles for human somatostatin receptor subtypes SST1–SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use , 2000, European Journal of Nuclear Medicine.
[128] J. Schaeffer,et al. Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. , 2000, Endocrinology.
[129] D. Hoyer,et al. Cloning, expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor. , 2000, Neuropharmacology.
[130] W. Meyerhof,et al. Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs , 1999, FEBS letters.
[131] D. Hoyer,et al. Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies , 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.
[132] D. Hoyer,et al. Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity , 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.
[133] D. Hoyer,et al. Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity , 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.
[134] P. Emson,et al. Visualisation of somatostatin receptor sst(3) in the rat central nervous system. , 1999, Brain research. Molecular brain research.
[135] J. Laissue,et al. Immunohistochemical detection of somatostatin sst2a receptors in the lymphatic, smooth muscular, and peripheral nervous systems of the human gastrointestinal tract: facts and artifacts. , 1999, The Journal of clinical endocrinology and metabolism.
[136] Y. Patel. Somatostatin and Its Receptor Family , 1999, Frontiers in Neuroendocrinology.
[137] A. Tashjian,et al. Identification of distinct signalling pathways for somatostatin receptors SSTR1 and SSTR2 as revealed by microphysiometry. , 1999, Cellular signalling.
[138] J. Taylor,et al. Highly potent cyclic disulfide antagonists of somatostatin. , 1999, Journal of medicinal chemistry.
[139] P. Rochaix,et al. Gene therapy for pancreatic carcinoma: local and distant antitumor effects after somatostatin receptor sst2 gene transfer. , 1999, Human gene therapy.
[140] D. Noonan,et al. Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[141] S. Schulz,et al. Selective targeting of somatostatin receptor 3 to neuronal cilia , 1999, Neuroscience.
[142] A. Michel,et al. Activation of adenylate cyclase by human recombinant sst5 receptors expressed in CHO‐K1 cells and involvement of Gαs proteins , 1999, British journal of pharmacology.
[143] P. Hayry,et al. Differential regulation of somatostatin receptor types 1–5 in rat aorta after angioplasty , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[144] W. Woodmansee,et al. Cloning of the mouse somatostatin receptor subtype 5 gene: promoter structure and function. , 1999, Endocrinology.
[145] J. Reubi,et al. Expression of somatostatin receptors in peritumoral veins of human tumors , 1999, Cancer.
[146] H. Yao,et al. Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1). , 1999, Molecular endocrinology.
[147] R. Houghten,et al. A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats. , 1998, Molecular Pharmacology.
[148] C. Tang,et al. Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. , 1998, Journal of medicinal chemistry.
[149] R G Smith,et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. , 1998, Science.
[150] J. Laissue,et al. Immunohistochemical localization of somatostatin receptor sst2A in human pancreatic islets. , 1998, The Journal of clinical endocrinology and metabolism.
[151] E. Kidd,et al. Molecular cloning and functional characterization of a rat somatostatin sst2(b) receptor splice variant , 1998, British journal of pharmacology.
[152] B H Arison,et al. Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[153] H. Wilkinson,et al. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. , 1998, Gastroenterology.
[154] D. Hoyer,et al. [125I]Tyr10-cortistatin14 labels all five somatostatin receptors , 1998, Naunyn-Schmiedeberg's Archives of Pharmacology.
[155] J. Epelbaum,et al. Characterization of Somatostatin Receptor Subtypes in Mammalian Pituitary , 1998, Annals of the New York Academy of Sciences.
[156] W. Meyerhof,et al. Cloning, Expression, Pharmacology and Tissue Distribution of the Mouse Somatostatin Receptor Subtype 5 , 1998, Journal of neuroendocrinology.
[157] J. Taylor,et al. Potent antagonists of somatostatin: synthesis and biology. , 1998, Journal of medicinal chemistry.
[158] J. Epelbaum,et al. Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT‐PCR study , 1998, The European journal of neuroscience.
[159] W. Meyerhof. The elucidation of somatostatin receptor functions: a current view. , 1998, Reviews of physiology, biochemistry and pharmacology.
[160] É. Mezey,et al. Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary. , 1998, Endocrinology.
[161] S. Krantic,et al. Somatostatin increases mitogen‐induced IL‐2 secretion and proliferation of human jurkat T cells via sst3 receptor isotype , 1998, Journal of cellular biochemistry.
[162] H. Kreienkamp,et al. Coupling of rat somatostatin receptor subtypes to a G‐protein gated inwardly rectifying potassium channel (GIRK1) , 1997, FEBS letters.
[163] R. Mangues,et al. S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ. , 1997, Cellular signalling.
[164] P. Caron,et al. Expression of somatostatin receptor SST4 in human placenta and absence of octreotide effect on human placental growth hormone concentration during pregnancy. , 1997, The Journal of clinical endocrinology and metabolism.
[165] A. Tsutsumi,et al. Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells. , 1997, Cellular immunology.
[166] Roy G. Smith,et al. Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. , 1997, Molecular endocrinology.
[167] C. Sternini,et al. Somatostatin 2A receptor is expressed by enteric neurons, and by interstitial cells of Cajal and enterochromaffin‐like cells of the gastrointestinal tract , 1997, The Journal of comparative neurology.
[168] W. Meyerhof,et al. Phosphorylation of Four Amino Acid Residues in the Carboxyl Terminus of the Rat Somatostatin Receptor Subtype 3 Is Crucial for Its Desensitization and Internalization* , 1997, The Journal of Biological Chemistry.
[169] A. Schally,et al. Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[170] N. Diehl,et al. Isolation and characterization of the gene encoding the type 5 mouse (Mus musculus) somatostatin receptor (msst5). , 1997, Gene.
[171] P. Dent,et al. Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness. , 1997, Molecular endocrinology.
[172] J. Sutcliffe,et al. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. , 1997, Genomics.
[173] H. Vaudry,et al. Differential Expression of Multiple Somatostatin Receptors in the Rat Cerebellum During Development , 1997, Journal of neurochemistry.
[174] É. Mezey,et al. Immunohistochemical Localization of Somatostatin Receptor SST2A in the Rat Pancreas. , 1997, Endocrinology.
[175] J. Friedman,et al. Agonist-induced Desensitization, Internalization, and Phosphorylation of the sst2A Somatostatin Receptor* , 1997, The Journal of Biological Chemistry.
[176] W. Feniuk,et al. Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism , 1997, British journal of pharmacology.
[177] N. Vaysse,et al. sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells. , 1997, Cancer research.
[178] G. Gillies. Somatostatin: the neuroendocrine story. , 1997, Trends in pharmacological sciences.
[179] S. Melmed,et al. Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. , 1997, The Journal of clinical investigation.
[180] E. Kidd,et al. A quantitative autoradiographical study on the distribution of somatostatin sst2 receptors in the rat central nervous system using [125I]-BIM-23027 , 1996, Neuropharmacology.
[181] M. Cattaneo,et al. A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroblastoma and in human small cell lung carcinoma cell lines , 1996, FEBS letters.
[182] M. Pausch,et al. Identification and characterization of novel somatostatin antagonists. , 1996, Molecular pharmacology.
[183] D. Hoyer,et al. Binding properties of somatostatin receptor subtypes. , 1996, Metabolism: clinical and experimental.
[184] G. Liapakis,et al. Molecular and functional properties of somatostain receptor subtypes. , 1996, Metabolism: clinical and experimental.
[185] A. Beaudet,et al. Localization of the Somatostatin Receptor SST2A in Rat Brain Using a Specific Anti-Peptide Antibody , 1996, The Journal of Neuroscience.
[186] O. Prospero-Garcia,et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties , 1996, Nature.
[187] G. Capellá,et al. Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer. , 1996, Cancer research.
[188] M. Dichter,et al. Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2+ current in the pituitary cell line AtT-20 , 1996, Neuroscience.
[189] A. Fusco,et al. Somatostatin inhibits PC Cl3 thyroid cell proliferation through the modulation of phosphotyrosine activity. Impairment of the somatostatinergic effects by stable expression of E1A viral oncogene. , 1996, The Journal of biological chemistry.
[190] P. Dent,et al. Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin. , 1996, The Biochemical journal.
[191] M. Le Romancer,et al. Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae. , 1996, Life sciences.
[192] G. Buell,et al. Differences in the operational characteristics of the human recombinant somatostatin receptor types, sst1 and sst2, in mouse fibroblast (Ltk−) cells , 1996, British journal of pharmacology.
[193] Y. Taché,et al. Intracerebroventricular injection of somatostatin sst5 receptor agonist inhibits gastric acid secretion in rats. , 1996, European journal of pharmacology.
[194] P. Emson,et al. Cellular localisation and co-expression of somatostatin receptor messenger RNAs in the human brain. , 1995, Brain research. Molecular brain research.
[195] H. Niznik,et al. The somatostatin receptor family. , 1995, Life sciences.
[196] A. Klibanski,et al. Somatostatin receptor subtype gene expression in pituitary adenomas. , 1995, The Journal of clinical endocrinology and metabolism.
[197] A. Beaudet,et al. Patterns of expression of SSTR1 and SSTR2 somatostatin receptor subtypes in the hypothalamus of the adult rat: relationship to neuroendocrine function , 1995, Neuroscience.
[198] D. Hoyer,et al. Classification and nomenclature of somatostatin receptors. , 1995, Trends in pharmacological sciences.
[199] S. Law,et al. Somatostatin receptor activation of cellular effector systems. , 1995, Cellular signalling.
[200] C. B. Srikant,et al. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). , 1994, Endocrinology.
[201] M. Loda,et al. The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells. , 1994, Molecular endocrinology.
[202] T. Reisine,et al. Characterization of cloned human somatostatin receptor SSTR5. , 1994, Molecular pharmacology.
[203] S. Seino,et al. Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1–5, in transfected COS‐7 cells , 1994, FEBS letters.
[204] E. Nishida,et al. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. , 1994, The Journal of biological chemistry.
[205] D. Barber,et al. Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2. , 1994, The Journal of biological chemistry.
[206] L. Mazzucchelli,et al. Intestinal vessels express a high density of somatostatin receptors in human inflammatory bowel disease. , 1994, Gastroenterology.
[207] G. Bell,et al. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[208] H. Niznik,et al. Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. , 1994, Molecular pharmacology.
[209] J. Laissue,et al. High density of somatostatin receptors in veins surrounding human cancer tissue: Role in tumor‐host interaction? , 1994, International journal of cancer.
[210] M. Berelowitz,et al. Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat. , 1993, Endocrinology.
[211] U. Studer,et al. Human kidney as target for somatostatin: high affinity receptors in tubules and vasa recta. , 1993, The Journal of clinical endocrinology and metabolism.
[212] E. Krenning,et al. In vitro autoradiographic and in vivo scintigraphic localization of somatostatin receptors in human lymphatic tissue. , 1993, Blood.
[213] D. Hoyer,et al. Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain , 1993, FEBS letters.
[214] H. Imura,et al. Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. , 1993, Biochemical and biophysical research communications.
[215] R. Espinosa,et al. Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2. , 1993, Genomics.
[216] G. Bell,et al. Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. , 1993, Molecular pharmacology.
[217] L. Rohrer,et al. Cloning and characterization of a fourth human somatostatin receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[218] P. Seeman,et al. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin‐14 like peptides , 1993, FEBS letters.
[219] M. Greenwood,et al. Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. , 1993, Biochemical and biophysical research communications.
[220] M. Stoffel,et al. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. , 1993, Genomics.
[221] L. Mahan,et al. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin: 28. , 1992, Molecular pharmacology.
[222] S. Seino,et al. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. , 1992, Molecular endocrinology.
[223] W. Meyerhof,et al. Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[224] S. Snyder,et al. Cloning and expression of a rat somatostatin receptor enriched in brain. , 1992, The Journal of biological chemistry.
[225] C. Saper,et al. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. , 1992, The Journal of biological chemistry.
[226] J. Laissue,et al. Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue. , 1992, Gastroenterology.
[227] C. Saper,et al. Differential expression of somatostatin receptor subtypes in brain , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[228] H. Lübbert,et al. Expression cloning of a rat brain somatostatin receptor cDNA. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[229] S. Seino,et al. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[230] S. Law,et al. Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors. , 1991, The Journal of biological chemistry.
[231] Bombesin-like peptides in health and disease. Proceedings of an international symposium. October 13-16, 1987, Rome, Italy. A tribute to Vittorio Erspamer, M.D. , 1988, Annals of the New York Academy of Sciences.
[232] Disease,et al. Bombesin-like peptides in health and disease , 1988 .
[233] M. Low,et al. Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells. , 1987, The Journal of biological chemistry.
[234] J. Palacios,et al. Distribution of somatostatin receptors in the human brain: An autoradiographic study , 1986, Neuroscience.
[235] J. Reubi,et al. Somatostatin receptors in the adrenal , 1986, Molecular and Cellular Endocrinology.
[236] G. Arbuthnott,et al. Different patterns of molecular forms of somatostatin are released by the rat median eminence and hypothalamus , 1985, Neuroscience Letters.
[237] J. Reubi. New specific radioligand for one subpopulation of brain somatostatin receptors. , 1985, Life sciences.
[238] J. Reubi,et al. Somatostatin Receptors , 1997, Trends in Endocrinology & Metabolism.
[239] T. Shows,et al. High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[240] W. Rutter,et al. Polymorphic human somatostatin gene is located on chromosome 3. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[241] W. Rutter,et al. Human somatostatin I: sequence of the cDNA. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[242] W. Vale,et al. High affinity binding sites for somatostatin to rat pituitary. , 1982, Biochemical and biophysical research communications.
[243] C. B. Srikant,et al. Somatostatin receptors: identification and characterization in rat brain membranes. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[244] W. Vale,et al. High affinity binding sites for a somatostatin-28 analog in rat brain. , 1981, Life sciences.
[245] V. Mutt,et al. N‐terminally extended somatostatin: The primary structure of somatostatin‐28 , 1980, FEBS letters.
[246] A. Tashjian,et al. Characterization of functional receptors for somatostatin in rat pituitary cells in culture. , 1978, The Journal of biological chemistry.
[247] L. Krulich,et al. Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. , 1968, Endocrinology.