Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury

[1]  S. Black.  Continuation of poor surgical outcome after elderly brain injury , 2009 .

[2]  C. Woolf,et al.  Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats , 2008, PAIN.

[3]  H. Chung,et al.  Molecular mechanism of PPAR in the regulation of age-related inflammation , 2008, Ageing Research Reviews.

[4]  M. Sawada,et al.  Effects of Aging on Neuroprotective and Neurotoxic Properties of Microglia in Neurodegenerative Diseases , 2008, Neurodegenerative Diseases.

[5]  N. Berman,et al.  Detrimental effects of aging on outcome from traumatic brain injury: a behavioral, magnetic resonance imaging, and histological study in mice. , 2008, Journal of Neurotrauma.

[6]  C. Kessler,et al.  Cellular and Molecular Events Underlying the Dysregulated Response of the Aged Brain to Stroke: A Mini-Review , 2007, Gerontology.

[7]  A. Merrill,et al.  Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue1 , 2007, The Journal of Immunology.

[8]  C. Kessler,et al.  The response of the aged brain to stroke: too much, too soon? , 2007, Current neurovascular research.

[9]  A. Chun,et al.  On the brain , 2007, Nature Nanotechnology.

[10]  Tetsuya Suhara,et al.  Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor , 2007, Brain Research.

[11]  C. Sanfeliu,et al.  Astrocytes aged in vitro show a decreased neuroprotective capacity , 2007, Journal of neurochemistry.

[12]  Mehmet Bilgen,et al.  A mouse model of sensorimotor controlled cortical impact: Characterization using longitudinal magnetic resonance imaging, behavioral assessments and histology , 2007, Journal of Neuroscience Methods.

[13]  H. Bramlett,et al.  Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies. , 2007, Progress in brain research.

[14]  B. Lyeth,et al.  Astroglia: important mediators of traumatic brain injury. , 2007, Progress in brain research.

[15]  A. Merrill,et al.  Tissue Inflammatory Mediators in Mouse Adipose Aging UpRegulates Expression of , 2007 .

[16]  G. Bertini,et al.  Cytokine-induced activation of glial cells in the mouse brain is enhanced at an advanced age , 2006, Neuroscience.

[17]  W. Streit,et al.  Effect of aging on the microglial response to peripheral nerve injury , 2006, Neurobiology of Aging.

[18]  M. Sofroniew,et al.  Essential protective roles of reactive astrocytes in traumatic brain injury. , 2006, Brain : a journal of neurology.

[19]  A. Kiss,et al.  Outcome after traumatic brain injury sustained in older adulthood: a one-year longitudinal study. , 2006, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[20]  W. Streit,et al.  Microglia in the Aging Brain , 2006, Journal of neuropathology and experimental neurology.

[21]  D. Brann,et al.  Role of astrocytes in reproduction and neuroprotection , 2006, Molecular and Cellular Endocrinology.

[22]  Michal Schwartz,et al.  Microglial phenotype: is the commitment reversible? , 2006, Trends in Neurosciences.

[23]  N. Rothwell,et al.  The role of inflammation in CNS injury and disease , 2006, British journal of pharmacology.

[24]  B. Marchetti,et al.  To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? , 2005, Trends in pharmacological sciences.

[25]  T. Grune,et al.  Chronically active: activation of microglial proteolysis in ageing and neurodegeneration , 2005, Redox report : communications in free radical research.

[26]  Jing Chen,et al.  Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system , 2005 .

[27]  K. Thomas,et al.  The CDC Traumatic Brain Injury Surveillance System: Characteristics of Persons Aged 65 Years and Older Hospitalized With a TBI , 2005, The Journal of head trauma rehabilitation.

[28]  P. Gasque,et al.  Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes, “protective” glial stem cells and stromal ependymal cells , 2005, Brain Research Reviews.

[29]  R. Mrak,et al.  Glia and their cytokines in progression of neurodegeneration , 2005, Neurobiology of Aging.

[30]  A. Raabe,et al.  GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. , 2004, Journal of neurotrauma.

[31]  V. Puri,et al.  Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice , 2004, Neuroscience Letters.

[32]  P. Stahel,et al.  The Role of Neuroinflammation in Traumatic Brain Injury , 2004, European Journal of Trauma.

[33]  Mark Ellisman,et al.  Absence of Glial Fibrillary Acidic Protein and Vimentin Prevents Hypertrophy of Astrocytic Processes and Improves Post-Traumatic Regeneration , 2004, The Journal of Neuroscience.

[34]  Keun-Young Kim,et al.  Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia , 2004, Neurobiology of Aging.

[35]  D. Sparks,et al.  Dystrophic microglia in the aging human brain , 2004, Glia.

[36]  G. Ashcroft,et al.  Ageing and wound healing , 2004, Biogerontology.

[37]  Allen W. Brown,et al.  Long-term survival after traumatic brain injury: a population-based analysis. , 2004, NeuroRehabilitation.

[38]  J. Habbema,et al.  Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients. , 2003, Journal of neurosurgery.

[39]  B. Liu,et al.  Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. , 2003, Environmental health perspectives.

[40]  B. Volpe,et al.  Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice , 2003, Brain Research.

[41]  H. Endo,et al.  Different glial reactions to hippocampal stab wounds in young adult and aged rats. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[42]  K. Tanev,et al.  Traumatic brain injury in older adults , 2002, Current psychiatry reports.

[43]  B. Liu,et al.  Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration , 2002, Annals of the New York Academy of Sciences.

[44]  G. Horgan,et al.  Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR , 2002 .

[45]  Erin D Bigler,et al.  Temporal lobe morphology in normal aging and traumatic brain injury. , 2002, AJNR. American journal of neuroradiology.

[46]  F. Goldstein,et al.  Cognitive Outcome After Mild and Moderate Traumatic Brain Injury in Older Adults , 2001, Journal of clinical and experimental neuropsychology.

[47]  M. O’Banion,et al.  Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury , 2001, Journal of Neuroimmunology.

[48]  L. Felzien,et al.  Increased chemokine gene expression during aging in the murine brain , 2001, Brain Research.

[49]  Y. Imai,et al.  Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. , 2000, Journal of cell science.

[50]  Richard Weindruch,et al.  Gene-expression profile of the ageing brain in mice , 2000, Nature Genetics.

[51]  P. Cheney,et al.  Microglial Activation and Neurological Symptoms in the SIV Model of NeuroAIDS: Association of MHC-II and MMP-9 Expression with Behavioral Deficits and Evoked Potential Changes , 1999, Neurobiology of Disease.

[52]  F. Amenta,et al.  Astrocyte changes in aging cerebral cortex and hippocampus: A quantitative immunohistochemical study , 1998, Microscopy research and technique.

[53]  N. Berman,et al.  Microglial Expression of MHC Class II Increases in Normal Aging of Nonhuman Primates , 1998, Neurobiology of Aging.

[54]  M. Childers,et al.  The effects of normal ageing on neuropsychological functioning following traumatic brain injury. , 1998, Brain injury.

[55]  C. Cotman,et al.  Life-Long Dietary Restriction Attenuates Age-Related Increases in Hippocampal Glial Fibrillary Acidic Protein mRNA , 1997, Neurobiology of Aging.

[56]  T. Morgan,et al.  Transcription supports age-related increases of GFAP gene expression in the male rat brain , 1996, Neuroscience Letters.

[57]  G. Kreutzberg.  Microglia: a sensor for pathological events in the CNS , 1996, Trends in Neurosciences.

[58]  J. Jolles,et al.  Long‐Term Persisting Cognitive Sequelae of Traumatic Brain Injury and the Effect of Age , 1996, The Journal of nervous and mental disease.

[59]  J. Trojanowski,et al.  Evidence of apoptotic cell death after experimental traumatic brain injury in the rat. , 1995, The American journal of pathology.

[60]  R. Hamm,et al.  Chronic corticosterone treatment potentiates deficits following traumatic brain injury in rats: implications for aging. , 1993, Journal of neurotrauma.

[61]  Timothy A. Springer,et al.  Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation , 1991, Cell.

[62]  C. Finch,et al.  Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain , 1991, Neurobiology of Aging.

[63]  B. Faddis,et al.  Trauma‐induced proliferation of astrocytes in the brains of young and aged rats , 1989, Glia.

[64]  Walter Dandy,et al.  The Brain , 1966 .