Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss).

[1]  D. Flockhart,et al.  Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms. , 1997, Drug metabolism and disposition: the biological fate of chemicals.

[2]  C. Handschin,et al.  The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals , 2004, Nuclear receptor.

[3]  S. George,et al.  Toxicity of malathion to nile tilapia, Oreochromis niloticus and modulation by other environmental contaminants , 1998 .

[4]  Taise Bresolin,et al.  Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish. , 2005, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[5]  C L Crespi,et al.  Fluorometric High‐Throughput Screening for Inhibitors of Cytochrome P450 , 2000, Annals of the New York Academy of Sciences.

[6]  Erik Kristiansson,et al.  Sensitive and robust gene expression changes in fish exposed to estrogen – a microarray approach , 2007, BMC Genomics.

[7]  Matthew D Krasowski,et al.  Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors) , 2005, Nuclear receptor.

[8]  Hegelund Myrbäck,et al.  Characterization of CYP3A in fish - expression, inhibition, induction and analyses of gene evolution , 2003 .

[9]  D. Friend,et al.  HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS , 1969, The Journal of cell biology.

[10]  N. Plant,et al.  IMPACT OF TRANSCRIPTION FACTOR PROFILE AND CHROMATIN CONFORMATION ON HUMAN HEPATOCYTE CYP3A GENE EXPRESSION , 2005, Drug Metabolism and Disposition.

[11]  T. Collier,et al.  Immunohistochemical localization of CYP1A and CYP3A-like isozymes in hepatic and extrahepatic tissues of Atlantic cod (Gadus morhua L.), a marine fish. , 1994, Toxicology and applied pharmacology.

[12]  S. Kliewer.  The nuclear pregnane X receptor regulates xenobiotic detoxification. , 2003, The Journal of nutrition.

[13]  S. Ekins,et al.  Evolution of pharmacologic specificity in the pregnane X receptor , 2008, BMC Evolutionary Biology.

[14]  B. Blumberg,et al.  Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and Its Orthologs in Laboratory, Toxicologic, and Genome Model Species , 2008, Environmental health perspectives.

[15]  Timothy M Willson,et al.  Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. , 2002, Molecular endocrinology.

[16]  Jonathan A Roling,et al.  Effects of nonylphenol on hepatic testosterone metabolism and the expression of acute phase proteins in winter flounder (Pleuronectes americanus): comparison to the effects of Saint John's Wort. , 2005, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[17]  Richard T. Di Giulio,et al.  The Toxicology of Fishes , 2008 .

[18]  H. Zhang,et al.  Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. , 1999, Archives of biochemistry and biophysics.

[19]  K. Fent,et al.  A microtiter‐plate‐based cytochrome P450 3A activity assay in fish cell lines , 2009, Environmental toxicology and chemistry.

[20]  Stegeman,et al.  Cellular localization of CYP3A proteins in various tissues from pilot whale (Globicephala melas). , 2000, Environmental toxicology and pharmacology.

[21]  M. Pesonen,et al.  Characterization and induction of xenobiotic metabolizing enzyme activities in a primary culture of rainbow trout hepatocytes. , 1991, Xenobiotica; the fate of foreign compounds in biological systems.

[22]  James R. Halpert,et al.  Alanine-scanning Mutagenesis of a Putative Substrate Recognition Site in Human Cytochrome P450 3A4 , 1997, The Journal of Biological Chemistry.

[23]  J. Lehmann,et al.  An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.

[24]  M. Celander,et al.  Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua) , 2005, Comparative hepatology.

[25]  W. Pryor.  Cytochrome P450: Structure, mechanism, and biochemistry , 1996 .

[26]  J. Schellens,et al.  PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line , 2009, Cancer Chemotherapy and Pharmacology.

[27]  M. Celander,et al.  Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus). , 2003, Aquatic toxicology.

[28]  M. E. Hahn,et al.  Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. , 1996, Archives of biochemistry and biophysics.

[29]  D. Buhler,et al.  Immunohistochemical localization and differential expression of cytochrome P450 3A27 in the gastrointestinal tract of rainbow trout. , 2001, Toxicology and applied pharmacology.

[30]  L. Förlin,et al.  Effects of clophen A50, 3-methylcholanthrene, pregnenolone-16 alpha-carbonitrile, and phenobarbital on the hepatic microsomal cytochrome P-450-dependent monooxygenase system in rainbow trout, Salmo gairdneri, of different age and sex. , 1980, Toxicology and applied pharmacology.

[31]  H. Tatsuta,et al.  Estrogenic modulation of CYP3A38, CYP3A40, and CYP19 in mature male medaka (Oryzias latipes). , 2007, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[32]  L. Moore,et al.  Paralogous vitamin D receptors in teleosts: transition of nuclear receptor function. , 2008, Endocrinology.

[33]  M. Ronis,et al.  Initial characterization of a constitutive cytochrome P-450 isoenzyme in rainbow trout liver , 1989 .

[34]  M. Krasowski,et al.  Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. , 2006, Current drug metabolism.

[35]  F. Guengerich,et al.  Human cytochrome P-450 enzymes. , 1992, Life sciences.

[36]  P. Beaune,et al.  Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. , 1990, The Journal of pharmacology and experimental therapeutics.

[37]  Joon-Woo Kim,et al.  Effects of synthetic polycyclic musks on estrogen receptor, vitellogenin, pregnane X receptor, and cytochrome P450 3A gene expression in the livers of male medaka (Oryzias latipes). , 2008, Aquatic toxicology.

[38]  J. Lehmann,et al.  The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. , 1998, The Journal of clinical investigation.

[39]  K. Fent,et al.  Ecotoxicology of human pharmaceuticals. , 2006, Aquatic toxicology.

[40]  A. Arukwe,et al.  The xenoestrogen 4-nonylphenol modulates hepatic gene expression of pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 in juvenile Atlantic salmon (Salmo salar). , 2006, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[41]  Ortiz de Montellano,et al.  Cytochrome P-450: Structure, Mechanism, and Biochemistry , 1986 .

[42]  B. M. Forman,et al.  The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux , 2001, Nature Medicine.

[43]  J. Pascussi,et al.  Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[44]  L. Förlin,et al.  Catalytic activity and immunochemical quantification of hepatic cytochrome P-450 in β-naphthoflavone and isosafrol treated rainbow trout (Oncorhynchus mykiss) , 1991, Fish Physiology and Biochemistry.

[45]  Timothy M Willson,et al.  The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. , 2002, Endocrine reviews.

[46]  Urban Olsson,et al.  Phylogenetic Analysis of the Cytochrome P450 3 (CYP3) Gene Family , 2003, Journal of Molecular Evolution.

[47]  A. Svardal,et al.  Effects of alkylphenols on CYP1A and CYP3A expression in first spawning Atlantic cod (Gadus morhua). , 2004, Aquatic toxicology.

[48]  M. Celander,et al.  Ketoconazole, an antifungal imidazole, increases the sensitivity of rainbow trout to 17alpha-ethynylestradiol exposure. , 2008, Aquatic toxicology.

[49]  L. Moore,et al.  The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution , 2000 .

[50]  K. Brøsen,et al.  Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide , 2004, European Journal of Clinical Pharmacology.

[51]  J. Pascussi,et al.  Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. , 2000, Molecular pharmacology.

[52]  S. Jørgensen,et al.  Occurrence, fate and effects of pharmaceutical substances in the environment--a review. , 1998, Chemosphere.

[53]  M. Celander,et al.  Effects of the antifungal imidazole ketoconazole on CYP1A and CYP3A in rainbow trout and killifish , 2004, Environmental toxicology and chemistry.