Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.
暂无分享,去创建一个
Volker M Lauschke | Magnus Ingelman-Sundberg | Delilah F G Hendriks | Tommy B Andersson | M. Ingelman-Sundberg | V. Lauschke | T. Andersson | Catherine C. Bell | D. Hendriks | Catherine C Bell
[1] M. Daly,et al. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin , 2009, Nature Genetics.
[2] Alison J. Foster,et al. Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes. , 2014, Toxicology in vitro : an international journal published in association with BIBRA.
[3] T. Andersson,et al. Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes , 2014, Archives of Toxicology.
[4] R. M. Owen,et al. An analysis of the attrition of drug candidates from four major pharmaceutical companies , 2015, Nature Reviews Drug Discovery.
[5] P Smith,et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. , 2000, Regulatory toxicology and pharmacology : RTP.
[6] Tommy B Andersson,et al. The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human , 2012, Expert opinion on drug metabolism & toxicology.
[7] N. Kaplowitz,et al. Mechanisms of drug-induced liver injury. , 2013, Clinics in liver disease.
[8] T. Andersson,et al. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells. , 2013, Biochemical pharmacology.
[9] Rosalind E. Jenkins,et al. Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication , 2015, Toxicological sciences : an official journal of the Society of Toxicology.
[10] M. Ingelman-Sundberg,et al. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease , 2016, Scientific Reports.
[11] K. Tilmant,et al. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins , 2012, Cell Biology and Toxicology.
[12] D. L. Taylor,et al. Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy. , 2017, Clinics in liver disease.
[13] M. Mcphail,et al. Character and Temporal Evolution of Apoptosis in Acetaminophen-Induced Acute Liver Failure* , 2013, Critical Care Medicine.
[14] P. Bernardi,et al. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening , 2006, Archives of Toxicology.
[15] J. Hornberg,et al. High-content analysis/screening for predictive toxicology: application to hepatotoxicity and genotoxicity. , 2014, Basic & clinical pharmacology & toxicology.
[16] Volker M. Lauschke,et al. Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury , 2017, Drug Metabolism and Disposition.
[17] D. Swinney,et al. How were new medicines discovered? , 2011, Nature Reviews Drug Discovery.
[18] M. Pangalos,et al. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework , 2014, Nature Reviews Drug Discovery.
[19] M. Mosedale,et al. Drug‐induced liver injury: Advances in mechanistic understanding that will inform risk management , 2017, Clinical pharmacology and therapeutics.
[20] D. Davidson,et al. Acute liver necrosis following overdose of paracetamol. , 1966, British medical journal.