The relationship between airflow and lung sound amplitude in normal subjects.

Few investigators have examined the relationship between airflow and lung sound amplitude; the available data are contradictory. I measured airflow at the mouth and compared the peak flow (Vmax) to mean and peak lung sound amplitude (mean AMP and peak AMP) at four sites on the chest wall (right and left anterior apices and posterior bases) in four healthy young adults. At each site, the sounds produced by 20 breaths at Vmax ranging between 1.5 and 4 L/s (Vvar) were measured by an automated technique. Ten breaths during nearly constant Vmax breathing (Vcon) also were measured at each site. The lung sound amplitudes at the four sites in each subject were grouped and compared to Vmax by linear regression analysis. The same sounds were also submitted to an automated V-correction procedure to evaluate its adequacy in automatically adjusting for the effect of variations in Vmax on lung sound amplitude. The data showed that lung sound amplitude (mean or peak) was linearly related to V in all subjects (r for mean AMP vs Vmax:0.77, 0.85, 0.69, 0.89; r for peak AMP vs Vmax:0.80, 0.83, 0.79, 0.88), p less than 1 X 10(-7) in all cases. The average mean AMP vs Vmax regression line slope was 0.42, and the average peak AMP vs Vmax regression line slope was 0.45. V-correction decreased the coefficient of variation of the Vvar sounds by 61 percent and flattened the average regression line slopes to 0.128. For the Vcon series, V-correction diminished the coefficient of variation from 12.2 to 10.0 percent. The relationship between lung sound amplitude and airflow appears to be substantially linear and this relationship can be used to adjust effectively for variations in airflow.

[1]  M Turner-Warwick,et al.  Breath sounds in emphysema. , 1969, British journal of diseases of the chest.

[2]  R. Peslin,et al.  Breath sounds in the clinical assessment of airflow obstruction. , 1978, Thorax.

[3]  George A. Gescheider,et al.  Psychophysics: Method and theory , 1976 .

[4]  Julius S. Bendat,et al.  Engineering Applications of Correlation and Spectral Analysis , 1980 .

[5]  S. Kraman,et al.  Lung sound intensity variability in normal men. A contour phonopneumographic study. , 1983, Chest.

[6]  P. Macklem,et al.  Demonstration of regional phase differences in ventilation by breath sounds. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[7]  S. Kraman,et al.  Comparison of lung sound and transmitted sound amplitude in normal men. , 1983, The American review of respiratory disease.

[8]  David G. Stork,et al.  The Physics of Sound , 1982 .

[9]  S. Kraman,et al.  Does the vesicular lung sound come only from the lungs? , 1983, The American review of respiratory disease.

[10]  S. Kraman,et al.  Vesicular lung sound amplitude mapping by automated flow-gated phonopneumography. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[11]  C. J. Martin,et al.  A test of the practical value of estimating breath sound intensity. Breath sounds related to measured ventilatory function. , 1976, Chest.

[12]  Wooten Ft,et al.  Method for respiratory sound analysis. , 1978 .

[13]  S. Kraman,et al.  Determination of the site of production of respiratory sounds by subtraction phonopneumography. , 2015, The American review of respiratory disease.