The influence of the cerebellum on experimental epilepsy.

Abstract The cerebellar influence on the cobalt experimental epilepsy has been investigated in unrestrained, unanesthetized rats by stimulation, total removal and temporary cooling of the cerebellum. Cerebellar stimulation generally provoked inhibition of the epileptic waves produced in the brain by cobalt application and depressed the sensory responses in the cerebral cortex. The occasional reversed facilitatory effects of the stimulation are discussed in the light of other peculiar effects of cerebellar stimulation. Total ablation of the cerebellum induced in epileptic rats a hypersynchrony of the background activity of the electrocorticogram and enhanced the clinical and electrocortical manifestations of experimental epilepsy in the unanesthetized rat. A similar tendency to hypersynchrony was occasionally seen in normal rats. The temporary cooling of the cerebellar surface in the unanesthetized, noncurarized rat produced a reversible increase in the spontaneous and sensory activated epileptic manifestations.

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