Calreticulin regulates TGF-β1-induced epithelial mesenchymal transition through modulating Smad signaling and calcium signaling.

[1]  M. Opas,et al.  Calreticulin Is Required for TGF-β-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells , 2017, Stem cell reports.

[2]  Yen-Chun Peng,et al.  Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial‐to‐mesenchymal transition , 2015, Molecular oncology.

[3]  M. Dong,et al.  Overexpression of Calreticulin Contributes to the Development and Progression of Pancreatic Cancer , 2014, Journal of cellular physiology.

[4]  D. Lodygin,et al.  IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. , 2014, The Journal of clinical investigation.

[5]  B. Davidson,et al.  Calreticulin expression is reduced in high-grade ovarian serous carcinoma effusions compared with primary tumors and solid metastases. , 2013, Human pathology.

[6]  G. Goodhill,et al.  Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent , 2013, Oncogene.

[7]  L. Wakefield,et al.  Beyond TGFβ: roles of other TGFβ superfamily members in cancer , 2013, Nature Reviews Cancer.

[8]  M. Michalak,et al.  Calreticulin signaling in health and disease. , 2012, The international journal of biochemistry & cell biology.

[9]  Jun Chen,et al.  Calreticulin as a potential diagnostic biomarker for lung cancer , 2012, Cancer Immunology, Immunotherapy.

[10]  Desma M. Grice,et al.  Non-Stimulated, Agonist-Stimulated and Store-Operated Ca2+ Influx in MDA-MB-468 Breast Cancer Cells and the Effect of EGF-Induced EMT on Calcium Entry , 2012, PloS one.

[11]  R. Xiang,et al.  Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. , 2011, Biochemical and biophysical research communications.

[12]  P. Kenny,et al.  Remodeling of Purinergic Receptor-Mediated Ca2+ Signaling as a Consequence of EGF-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells , 2011, PloS one.

[13]  Gry H. Dihazi,et al.  Calreticulin is crucial for calcium homeostasis mediated adaptation and survival of thick ascending limb of Henle's loop cells under osmotic stress. , 2011, The international journal of biochemistry & cell biology.

[14]  D. Saur,et al.  IKKα controls canonical TGFβ–SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells , 2010, Journal of Cell Science.

[15]  F. Chew,et al.  Clinicopathological significance of calreticulin in breast invasive ductal carcinoma , 2010, Modern Pathology.

[16]  R. Huang,et al.  Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.

[17]  A. Gressner,et al.  Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor β actions in hepatocytes—But without modulating bone morphogenetic protein 7 signaling , 2009, Hepatology.

[18]  M. Ho,et al.  Identification of Calreticulin as a Prognosis Marker and Angiogenic Regulator in Human Gastric Cancer , 2009, Annals of Surgical Oncology.

[19]  Robert A. Weinberg,et al.  Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. , 2008, Developmental cell.

[20]  Qiong Li,et al.  Proteome analysis of human androgen‐independent prostate cancer cell lines: Variable metastatic potentials correlated with vimentin expression , 2007, Proteomics.

[21]  H. Kanetake,et al.  Calreticulin Represses E-cadherin Gene Expression in Madin-Darby Canine Kidney Cells via Slug* , 2006, Journal of Biological Chemistry.

[22]  I. Nagata,et al.  Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. , 2006, Cancer research.

[23]  D. Lai,et al.  Calreticulin expression in neuroblastoma--a novel independent prognostic factor. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[24]  Marek Michalak,et al.  Calreticulin Differentially Modulates Calcium Uptake and Release in the Endoplasmic Reticulum and Mitochondria* , 2002, The Journal of Biological Chemistry.

[25]  A. Reith,et al.  SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. , 2002, Molecular pharmacology.

[26]  Peter Lipp,et al.  Calcium - a life and death signal , 1998, Nature.

[27]  S. Grinstein,et al.  Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion , 1997, Nature.

[28]  K. Krause,et al.  Overexpression of Calreticulin Increases Intracellular Ca Storage and Decreases Store-operated Ca Influx (*) , 1996, The Journal of Biological Chemistry.

[29]  P. Cullen,et al.  Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Tumorigenesis and Neoplastic Progression Suppressive Roles of Calreticulin in Prostate Cancer Growth and Metastasis , 2022 .