CD4+CD126low/- Foxp3+ Cell Population Represents a Superior Subset of Regulatory T Cells in Treating Autoimmune Diseases.

[1]  S. Zheng,et al.  Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4+ Treg Cells in Patients with Rheumatoid Arthritis , 2019, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

[2]  C. Benoist,et al.  Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis , 2019, Nature.

[3]  T. Karonitsch,et al.  The immunobiology of mTOR in autoimmunity. , 2019, Journal of autoimmunity.

[4]  D. Butterfield,et al.  Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment ("chemobrain"), a condition that significantly impairs the quality of life of many cancer survivors. , 2019, Biochimica et biophysica acta. Molecular basis of disease.

[5]  M. V. von Herrath,et al.  Regulatory Immune Mechanisms beyond Regulatory T Cells. , 2019, Trends in immunology.

[6]  Hiromasa Morikawa,et al.  PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer , 2019, Proceedings of the National Academy of Sciences.

[7]  S. Zheng,et al.  Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells , 2019, Cell reports.

[8]  S. Zheng,et al.  1,25-Dihydroxyvitamin D3 Ameliorates Collagen-Induced Arthritis via Suppression of Th17 Cells Through miR-124 Mediated Inhibition of IL-6 Signaling , 2019, Front. Immunol..

[9]  S. Zheng,et al.  Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells , 2019, Cells.

[10]  S. Zheng,et al.  Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4+Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases , 2019, Cell Death & Disease.

[11]  S. Zheng,et al.  A protocol to develop T helper and Treg cells in vivo , 2017, Cellular & Molecular Immunology.

[12]  J. Todd,et al.  Human IL-6RhiTIGIT− CD4+ CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile , 2017, Clinical immunology.

[13]  J. Todd,et al.  In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment , 2017, Data in brief.

[14]  S. Zheng,et al.  Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms , 2016, Front. Immunol..

[15]  T. Honjo,et al.  Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model , 2016, Proceedings of the National Academy of Sciences.

[16]  S. Zheng,et al.  TGF-β–Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism , 2016, The Journal of Immunology.

[17]  B. Chiang,et al.  Lymphocyte-activation gene 3(+) (LAG3(+)) forkhead box protein 3(-) (FOXP3(-)) regulatory T cells induced by B cells alleviates joint inflammation in collagen-induced arthritis. , 2016, Journal of autoimmunity.

[18]  S. Zheng,et al.  The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis. , 2015, International journal of clinical and experimental medicine.

[19]  S. Rose-John,et al.  Interleukin-6 and its receptors: a highly regulated and dynamic system. , 2014, Cytokine.

[20]  C. Benoist,et al.  Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. , 2014, Immunity.

[21]  Hiroshi Takayanagi,et al.  Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis , 2013, Nature Medicine.

[22]  T. Mak,et al.  Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR) , 2013, Cell cycle.

[23]  Zhiyong Guo,et al.  Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. , 2013, Arthritis and rheumatism.

[24]  H. Nie,et al.  Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis , 2013, Nature Medicine.

[25]  Chester Ni,et al.  In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6–Mediated Signaling , 2013, Science Translational Medicine.

[26]  B. Bonnotte,et al.  Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. , 2012, Arthritis and rheumatism.

[27]  S. Zheng,et al.  Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. , 2012, Arthritis and rheumatism.

[28]  S. Zheng,et al.  Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells , 2012, Annals of the rheumatic diseases.

[29]  Simon A. Jones,et al.  Foxp3+ Treg cells in the inflamed CNS are insensitive to IL‐6‐driven IL‐17 production , 2012, European journal of immunology.

[30]  Herman Waldmann,et al.  Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. , 2012, Immunity.

[31]  S. Zheng,et al.  Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? , 2012, Journal of molecular cell biology.

[32]  A. Rudensky,et al.  Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. , 2011, Immunity.

[33]  S. Zheng,et al.  The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients , 2010, Clinical Rheumatology.

[34]  Loise M. Francisco,et al.  PD-L1 regulates the development, maintenance, and function of induced regulatory T cells , 2009, The Journal of experimental medicine.

[35]  A. Levine,et al.  IL-6 Signaling in Psoriasis Prevents Immune Suppression by Regulatory T Cells1 , 2009, The Journal of Immunology.

[36]  J. Bluestone,et al.  Plasticity of CD4(+) FoxP3(+) T cells. , 2009, Current opinion in immunology.

[37]  S. Zheng,et al.  Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. , 2008, Trends in immunology.

[38]  J. Ward,et al.  TGF‐β‐induced Foxp3+ regulatory T cells rescue scurfy mice , 2008, European journal of immunology.

[39]  S. Zheng,et al.  Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-61 , 2008, The Journal of Immunology.

[40]  E. Chi,et al.  Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. , 2008, Immunity.

[41]  W. Strober,et al.  Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β , 2007, The Journal of Immunology.

[42]  M. Ehrenstein,et al.  Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β , 2007, The Journal of experimental medicine.

[43]  T. Gingeras,et al.  CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells , 2006, The Journal of experimental medicine.

[44]  C. Cilio,et al.  Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T‐cell‐mediated suppression , 2006, Immunology.

[45]  R. J. Hocking,et al.  TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.

[46]  P. Saunders,et al.  PD‐L2:PD‐1 involvement in T cell proliferation, cytokine production, and integrin‐mediated adhesion , 2005, European journal of immunology.

[47]  Linrong Lu,et al.  Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[48]  G. Freeman,et al.  CD4 CD25 T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion , 2004 .

[49]  G. Kollias,et al.  Interleukin 6 Is Required for the Development of Collagen-induced Arthritis , 1998, The Journal of experimental medicine.

[50]  S. Akira,et al.  STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[51]  K. Rajewsky,et al.  Interleukin-10-deficient mice develop chronic enterocolitis , 1993, Cell.