External standard method for the in vivo quantification of choline‐containing compounds in breast tumors by proton MR spectroscopy at 1.5 Tesla

Quantification of choline‐containing compounds observed with 1H MRS of breast tumors is of interest since such compounds have been linked to malignancy. Experiments were performed at 1.5 T with an external standard containing phosphocholine for calibration. In phantom studies, good precision was achieved after correction for T1/T2 effects. T2 values for choline were estimated for two breast cancer patients. A choline concentration of 2.0 mM was calculated for a third patient, a result comparable to in vitro findings. Magn Reson Med 46:189–192, 2001. © 2001 Wiley‐Liss, Inc.

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