Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease.

We evaluated basal plasma total immunoreactive insulin (insulin), androstenedione, and testosterone in 14 obese women: 8 with polycystic ovarian disease (PCOD) and 6 obese controls. All 3 hormones were significantly elevated (P less than 0.02 to P less than 0.001) in PCOD patients. A significant correlation among basal levels of plasma insulin, androstenedione, and testosterone was demonstrated. The PCOD group had significantly higher levels of glucose at 1, 2, and 3 h, with similar significant increases in plasma insulin levels at 0, 2, and 3 h. A significant correlation was found between plasma insulin response areas and plasma testosterone (P less than 0.001) in the control and PCOD patients. These studies demonstrate that hyperandrogenism correlates with hyperinsulinism.

[1]  E. Schillinger,et al.  Changes in insulin receptor concentration in rat fat cells following treatment with the gestagens clomegestone acetate and cyproterone acetate. , 1977, Acta endocrinologica.

[2]  The effect of age on plasma proinsulin-like material after oral glucose. , 1976 .

[3]  R. Jones,et al.  A Note on the Effect of Certain Androgens Upon the Red Blood Cell Count and Upon the Glucose Tolerance , 1941 .

[4]  W. Duckworth,et al.  Accelerated Insulin Degradation: An Alternate Mechanism for Insulin Resistance , 1979, Diabetes Care.

[5]  V. Wynn,et al.  THE EFFECT OF ANABOLIC STEROIDS ON BLOOD SUGAR AND PLASMA INSULIN LEVELS IN MAN. , 1963, Metabolism: clinical and experimental.

[6]  C. Kahn,et al.  The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. , 1976, The New England journal of medicine.

[7]  M. Talaat,et al.  The effect of testosterone on the carbohydrate metabolism in normal subjects. , 1957, Archives internationales de pharmacodynamie et de therapie.

[8]  C. Kahn.  Insulin Receptors in Disease States , 1979 .

[9]  E. Mccullagh,et al.  Carbohydrate Metabolism of Patients Treated with Methyl Testosterone , 1942 .

[10]  C. R. Morgan,et al.  Further Studies of an Inhibitor of the Two Antibody Immunoassay System , 1964, Diabetes.

[11]  J. Olefsky.  Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. , 1976, The Journal of clinical investigation.

[12]  W. Duckworth,et al.  Direct measurement of proinsulin in human plasma by the use of an insulin-degrading enzyme. , 1971, The Journal of clinical investigation.

[13]  J. Goldzieher.  Polycystic ovarian disease. , 1981, Clinical obstetrics and gynecology.

[14]  J. Givens.  Hirsutism and hyperandrogenism. , 1976, Advances in internal medicine.

[15]  W. Rosner.  A simplified method for the quantitative determination of testosterone-estradiol-binding globulin activity in human plasma. , 1972, The Journal of clinical endocrinology and metabolism.

[16]  D. Schalch,et al.  A Sensitive Double Antibody Immunoassay for Human Growth Hormone in Plasma , 1964, Nature.

[17]  V. Wynn,et al.  Effects of anabolic steroid, methandienone, on carbohydrate metabolism in man. , 1962, Metabolism: clinical and experimental.

[18]  L. Harrison,et al.  Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects. , 1976, The Journal of clinical investigation.

[19]  W. Duckworth,et al.  Direct measurement of plasma proinsulin in normal and diabetic subjects. , 1972, The American journal of medicine.