Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.

[1]  Rakesh K. Jain,et al.  Vascular and interstitial barriers to delivery of therapeutic agents in tumors , 1990, Cancer and Metastasis Reviews.

[2]  R. Weissleder,et al.  Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. , 2002, Radiology.

[3]  Ralph Weissleder,et al.  Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. , 2002, Gastroenterology.

[4]  Ralph Weissleder,et al.  In vivo molecular target assessment of matrix metalloproteinase inhibition , 2001, Nature Medicine.

[5]  S. Achilefu,et al.  Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. , 2001, Journal of biomedical optics.

[6]  W. Semmler,et al.  Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands , 2001, Nature Biotechnology.

[7]  A. Libchaber,et al.  Single-mismatch detection using gold-quenched fluorescent oligonucleotides , 2001, Nature Biotechnology.

[8]  P. Jiang,et al.  Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[9]  P. Carmeliet,et al.  In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy , 2001, Nature Medicine.

[10]  Daniel J. Hawrysz,et al.  Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents. , 2000, Neoplasia.

[11]  V. Ntziachristos,et al.  Hydrophilic Cyanine Dyes as Contrast Agents for Near-infrared Tumor Imaging: Synthesis, Photophysical Properties and Spectroscopic In vivo Characterization¶ , 2000, Photochemistry and photobiology.

[12]  R Weissleder,et al.  In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. , 2000, Cancer research.

[13]  Wolfhard Semmler,et al.  Macromolecular Contrast Agents for Optical Imaging of Tumors: Comparison of Indotricarbocyanine-labeled Human Serum Albumin and Transferrin¶ , 2000, Photochemistry and photobiology.

[14]  M J Holboke,et al.  Three-dimensional diffuse optical mammography with ultrasound localization in a human subject. , 2000, Journal of biomedical optics.

[15]  R. J. Gaudette,et al.  A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient. , 2000, Physics in medicine and biology.

[16]  V. Ntziachristos,et al.  Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[17]  B. Fingleton,et al.  Matrix metalloproteinases: biologic activity and clinical implications. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  Bonnie F. Sloane,et al.  Unraveling the role of proteases in cancer. , 2000, Clinica chimica acta; international journal of clinical chemistry.

[19]  R Weissleder,et al.  Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model. , 2000, Radiology.

[20]  H. Dvorak,et al.  Different pathways of macromolecule extravasation from hyperpermeable tumor vessels. , 2000, Microvascular research.

[21]  L. Svaasand,et al.  Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. , 2000, Neoplasia.

[22]  Bonnie F. Sloane,et al.  Observing proteases in living cells. , 2000, Advances in experimental medicine and biology.

[23]  R Weissleder,et al.  Near-infrared optical imaging of protease activity for tumor detection. , 1999, Radiology.

[24]  C. Contag,et al.  Noninvasive assessment of tumor cell proliferation in animal models. , 1999, Neoplasia.

[25]  R Weissleder,et al.  Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. , 1999, Bioconjugate chemistry.

[26]  S. Shapiro.  Diverse Roles of Macrophage Matrix Metalloproteinases in Tissue Destruction and Tumor Growth , 1999, Thrombosis and Haemostasis.

[27]  M. Kuwano,et al.  Biological implications of macrophage infiltration in human tumor angiogenesis , 1999, Cancer Chemotherapy and Pharmacology.

[28]  R. Weissleder,et al.  In vivo imaging of tumors with protease-activated near-infrared fluorescent probes , 1999, Nature Biotechnology.

[29]  R. Webb,et al.  Video-rate confocal scanning laser microscope for imaging human tissues in vivo. , 1999, Applied optics.

[30]  A. Fischman,et al.  Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[31]  B. Nielsen,et al.  Cancer invasion and tissue remodeling‐cooperation of protease systems and cell types , 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[32]  Sanjay Tyagi,et al.  Multiplex detection of single-nucleotide variations using molecular beacons. , 1999, Genetic analysis : biomolecular engineering.

[33]  R Weissleder,et al.  Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis. , 1998, Microvascular research.

[34]  R. Xavier,et al.  Tumor Induction of VEGF Promoter Activity in Stromal Cells , 1998, Cell.

[35]  R Weissleder,et al.  Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging. , 1998, AJR. American journal of roentgenology.

[36]  R Weissleder,et al.  Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model. , 1998, Bioconjugate chemistry.

[37]  K. Sakatani,et al.  Noninvasive optical imaging of the subarachnoid space and cerebrospinal fluid pathways based on near-infrared fluorescence. , 1997, Journal of neurosurgery.

[38]  Dario Neri,et al.  Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform , 1997, Nature Biotechnology.

[39]  Y. Miyagi,et al.  Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. , 1997, Cancer research.

[40]  P. Basset,et al.  Matrix metalloproteinases as stromal effectors of human carcinoma progression: therapeutic implications. , 1997, Matrix biology : journal of the International Society for Matrix Biology.

[41]  R. Weissleder,et al.  A long-circulating co-polymer in "passive targeting" to solid tumors. , 1997, Journal of drug targeting.

[42]  Y. DeClerck,et al.  Proteases and protease inhibitors in tumor progression. , 1997, Advances in experimental medicine and biology.

[43]  P. Courtoy,et al.  v-Src induces constitutive macropinocytosis in rat fibroblasts. , 1996, Journal of cell science.

[44]  R K Jain,et al.  Delivery of Molecular Medicine to Solid Tumors , 1996, Science.

[45]  R. Weissleder,et al.  An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties. , 1996, Bioconjugate chemistry.

[46]  L. Matrisian,et al.  Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression. , 1994, Invasion & metastasis.

[47]  J. Mohler,et al.  Flow cytometric assay of pinocytosis: correlation with membrane ruffling and metastatic potential in the Dunning R-3327 rat prostatic adenocarcinoma model. , 1993, Cytometry.

[48]  R Weissleder,et al.  A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies. , 1993, Radiology.

[49]  J. Swanson,et al.  Macropinosome maturation and fusion with tubular lysosomes in macrophages , 1993, The Journal of cell biology.

[50]  L. Liotta,et al.  Tumor cell interactions with the extracellular matrix during invasion and metastasis. , 1993, Annual review of cell biology.

[51]  H. Dvorak,et al.  Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels. , 1992, Laboratory investigation; a journal of technical methods and pathology.

[52]  J. Swanson,et al.  Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages , 1989, The Journal of experimental medicine.

[53]  Bonnie F. Sloane,et al.  Lysosomal cathepsin B: correlation with metastatic potential. , 1981, Science.

[54]  V. Levin,et al.  Factors influencing the survival of rat brain tumor cells after in vitro treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea. , 1975, Cancer research.