Recent advances in the combination of capillary electrophoresis with mass spectrometry: From element to single‐cell analysis

This overview deals with the latest development of electrophoresis in capillaries and microfluidic devices coupled to MS detection. A wide selection of relevant articles covers the literature published from January 2010 till June 2012 as a continuation of the review article on the same topic by Pantuckova et al. [Electrophoresis 2011, 32, 43–51]. Special attention is paid to the new improvements in instrumentation and methodology of three interfacing methods, ESI, matrix‐assisted desorption/ionization, and ICP. Representative examples illustrate applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis and single‐cell analysis. The combinations of MS with capillary versions of electrochromatography, ITP, IEF, and micellar electrokinetic chromatography are not included.

[1]  Angelina Taichrib,et al.  High resolution TOF MS coupled to CE for the analysis of isotopically resolved intact proteins. , 2011, Journal of proteomics.

[2]  Carmen García-Ruiz,et al.  Sensitive determination of D-carnitine as enantiomeric impurity of levo-carnitine in pharmaceutical formulations by capillary electrophoresis-tandem mass spectrometry. , 2010, Journal of pharmaceutical and biomedical analysis.

[3]  G. D. de Jong,et al.  Performance of a sheathless porous tip sprayer for capillary electrophoresis-electrospray ionization-mass spectrometry of intact proteins. , 2010, Journal of chromatography. A.

[4]  A. Timerbaev,et al.  Recent progress in the application of analytical techniques to anticancer metallodrug proteomics , 2011 .

[5]  C. Neusüss,et al.  The selective determination of sulfates, sulfonates and phosphates in urine by CE‐MS , 2010, Electrophoresis.

[6]  Yongning Wu,et al.  Speciation analysis of selenium in rice samples by using capillary electrophoresis-inductively coupled plasma mass spectrometry. , 2011, Talanta.

[7]  Yatin R. Gokarn,et al.  Analytical methods for physicochemical characterization of antibody drug conjugates , 2011, mAbs.

[8]  B. Chung,et al.  Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach. , 2010, Analytica chimica acta.

[9]  Andrew G Chambers,et al.  Microfluidic dual emitter electrospray ionization source for accurate mass measurements. , 2012, Analytical chemistry.

[10]  J. Veuthey,et al.  CE‐ESI‐TOF/MS for human growth hormone analysis , 2010, Electrophoresis.

[11]  T. Takeuchi,et al.  Simultaneous determination of antidepressants by non-aqueous capillary electrophoresis-time of flight mass spectrometry. , 2010, Journal of chromatography. A.

[12]  J. Bergquist,et al.  Optimizing the extraction, separation and quantification of tricyclic antidepressant drugs in human plasma with CE‐ESI‐TOF‐MS using cationic‐coated capillaries , 2011, Electrophoresis.

[13]  C. Huck,et al.  Peptide mapping using capillary electrophoresis offline coupled to matrix‐assisted laser desorption ionization time of flight mass spectrometry , 2011, Electrophoresis.

[14]  Cai Tie,et al.  A new labelling reagent for glycans analysis by capillary electrophoresis-mass spectrometry , 2012 .

[15]  Gerhard K. E. Scriba,et al.  Identification and characterization of impurities of tetracosactide by capillary electrophoresis and liquid chromatography coupled to time-of-flight mass spectrometry , 2011, Analytical and bioanalytical chemistry.

[16]  M. Kaljurand,et al.  Electrowetting-on-dielectric actuation of droplets with capillary electrophoretic zones for off-line mass spectrometric analysis. , 2012, Journal of chromatography. A.

[17]  T. T. Nguyen,et al.  Investigation of a liposomal oxaliplatin drug formulation by capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry (CE-ICP-MS) , 2012, Analytical and Bioanalytical Chemistry.

[18]  Angelina Taichrib,et al.  Toward a screening method for the analysis of small intact proteins by CE‐ESI‐TOF MS , 2012, Electrophoresis.

[19]  K. Kakehi,et al.  Recent advances in the analysis of carbohydrates for biomedical use. , 2011, Journal of pharmaceutical and biomedical analysis.

[20]  S. Fanali,et al.  Analysis of drugs of forensic interest with capillary zone electrophoresis/time‐of‐flight mass spectrometry based on the use of non‐volatile buffers , 2012, Electrophoresis.

[21]  B. Li.  Rapid speciation analysis of by short column capillary electrophoresis on-line coupled with inductively coupled plasma mass spectrometry. , 2011, Analytical methods : advancing methods and applications.

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[23]  Michael Sperling,et al.  Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications , 2012, Analytical and Bioanalytical Chemistry.

[24]  C. Buchberger.  Recent Advances in the Use of Capillary Electrophoresis Coupled to High-Resolution Mass Spectrometry for the Analysis of Small Molecules , 2010 .

[25]  Rawi Ramautar,et al.  CE‐MS for metabolomics: Developments and applications in the period 2008–2010 , 2011, Electrophoresis.

[26]  Fengjun Shang,et al.  Recent advances in miniaturisation – The role of microchip electrophoresis in clinical analysis , 2012, Electrophoresis.

[27]  E. Maxwell,et al.  A promising capillary electrophoresis–electrospray ionization–mass spectrometry method for carbohydrate analysis , 2011, Electrophoresis.

[28]  R. Carabias-Martínez,et al.  Determination of endocrine disruptors in honey by CZE‐MS using restricted access materials for matrix cleanup , 2010, Electrophoresis.

[29]  S. Topin,et al.  Stability constants determination of successive metal complexes by hyphenated CE‐ICPMS , 2010, Electrophoresis.

[30]  J. Sweedler,et al.  Profiling metabolites and peptides in single cells , 2011, Nature Methods.

[31]  S. Ohla,et al.  Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrometry , 2011, Analytical and bioanalytical chemistry.

[32]  M. Himmelsbach,et al.  A sensitive non-aqueous capillary electrophoresis-mass spectrometric method for multiresidue analyses of beta-agonists in pork. , 2009, Biomedical chromatography : BMC.

[33]  R. Zare,et al.  Interfacing capillary-based separations to mass spectrometry using desorption electrospray ionization. , 2011, Analytical chemistry.

[34]  Chun-song Zheng,et al.  CE‐ESI‐MS coupled with dynamic pH junction online concentration for analysis of peptides in human urine samples , 2010, Electrophoresis.

[35]  Capillary electrophoresis-mass spectrometry using noncovalently coated capillaries for the analysis of biopharmaceuticals , 2011, Analytical and bioanalytical chemistry.

[36]  A. Fanigliulo,et al.  Monitoring compliance to therapy during addiction treatments by means of hair analysis for drugs and drug metabolites using capillary zone electrophoresis coupled to time-of-flight mass spectrometry. , 2012, Forensic science international.

[37]  O. Shpigun,et al.  Chiral analysis of pharmaceuticals by capillary electrophoresis using antibiotics as chiral selectors. , 2010, Journal of pharmaceutical and biomedical analysis.

[38]  A. Gómez-Caravaca,et al.  Development of a CE‐ESI‐microTOF‐MS method for a rapid identification of phenolic compounds in buckwheat , 2011, Electrophoresis.

[39]  Serge Rudaz,et al.  Evaluation of a sheathless nanospray interface based on a porous tip sprayer for CE‐ESI‐MS coupling , 2012, Electrophoresis.

[40]  R. Zenobi,et al.  Miniature flowing atmospheric‐pressure afterglow ion source for facile interfacing of CE with MS , 2010, Electrophoresis.

[41]  L. Sánchez-Hernández,et al.  Determination of betaines in vegetable oils by capillary electrophoresis tandem mass spectrometry – application to the detection of olive oil adulteration with seed oils , 2011, Electrophoresis.

[42]  M. Himmelsbach,et al.  Determination of cinchona alkaloids by non‐aqueous CE with MS detection , 2010, Electrophoresis.

[43]  M. Tomita,et al.  Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles , 2009, Metabolomics.

[44]  Fabrication of low-melting-point alloy microelectrode and monolithic spray tip for integration of glass chip with electrospray ionization mass spectrometry. , 2010, Talanta.

[45]  Serge Rudaz,et al.  Multiple injection technique for the determination and quantitation of insulin formulations by capillary electrophoresis and time-of-flight mass spectrometry. , 2010, Journal of chromatography. A.

[46]  D. Pröfrock.  Progress and possible applications of miniaturised separation techniques and elemental mass spectrometry for quantitative, heteroatom-tagged proteomics , 2010, Analytical and bioanalytical chemistry.

[47]  J. Quirino.  CZE and ESI-MS of Borate-Sugar Complexes , 2010 .

[48]  R. Kautenburger,et al.  Complexation of europium and uranium by humic acids analyzed by capillary electrophoresis‐inductively coupled plasma mass spectrometry , 2012, Electrophoresis.

[49]  G. Jiang,et al.  Characterization of interactions between organotin compounds and human serum albumin by capillary electrophoresis coupled with inductively coupled plasma mass spectrometry. , 2012, Talanta.

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[51]  Derek J. Wilson,et al.  Understanding and optimizing electrospray ionization techniques for proteomic analysis , 2011, Expert review of proteomics.

[52]  M. Bustamante-Rangel,et al.  Analysis of isoflavones in soy drink by capillary zone electrophoresis coupled with electrospray ionization mass spectrometry. , 2012, Analytica chimica acta.

[53]  E. J. Song,et al.  Growing trend of CE at the omics level: The frontier of systems biology , 2010, Electrophoresis.

[54]  N. Dovichi,et al.  Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry as an alternative proteomics platform to ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry for samples of intermediate complexity. , 2012, Analytical chemistry.

[55]  J. Barbosa,et al.  Analysis of recombinant human erythropoietin glycopeptides by capillary electrophoresis electrospray-time of flight-mass spectrometry. , 2012, Analytica chimica acta.

[56]  Alejandro Cifuentes,et al.  Chiral CE‐MS , 2010, Electrophoresis.

[57]  A. Zamfir,et al.  High‐performance separation techniques hyphenated to mass spectrometry for ganglioside analysis , 2011, Electrophoresis.

[58]  R. Ramautar,et al.  Enhancing the coverage of the urinary metabolome by sheathless capillary electrophoresis-mass spectrometry. , 2012, Analytical chemistry.

[59]  Masato Watanabe,et al.  Highly sensitive oligosaccharide analysis in capillary electrophoresis using large-volume sample stacking with an electroosmotic flow pump. , 2012, Journal of chromatography. A.

[60]  F. Altmann,et al.  Glycosylation Analysis of Proteins, Proteoglycans, and Glycolipids Using Capillary Electrophoresis and Mass Spectrometry. , 2011, Advances in chromatography.

[61]  Rawi Ramautar,et al.  High capacity capillary electrophoresis-electrospray ionization mass spectrometry: coupling a porous sheathless interface with transient-isotachophoresis. , 2010, Analytical chemistry.

[62]  R. Ramautar,et al.  Evaluation of CE methods for global metabolic profiling of urine , 2010, Electrophoresis.

[63]  Xiu‐Ping Yan,et al.  Probing interactions of antimony species with DNA by short column capillary electrophoresis coupled with inductively coupled plasma mass spectrometry , 2011 .

[64]  L. Holland,et al.  Capillary electrophoresis coupled to electrospray mass spectrometry through a coaxial sheath flow interface and semi‐permanent phospholipid coating for the determination of oligosaccharides labeled with 1‐aminopyrene‐3,6,8‐trisulfonic acid , 2012, Electrophoresis.

[65]  Lloyd M Smith,et al.  Integrated microfluidic device for automated single cell analysis using electrophoretic separation and electrospray ionization mass spectrometry. , 2010, Analytical chemistry.

[66]  P. Boček,et al.  Electrophoresis today and tomorrow: Helping biologists' dreams come true , 2010, BioEssays : news and reviews in molecular, cellular and developmental biology.

[67]  Alejandro Cifuentes,et al.  Chiral capillary electrophoresis in food analysis , 2010, Electrophoresis.

[68]  E. Maxwell,et al.  Decoupling CE and ESI for a more robust interface with MS , 2010, Electrophoresis.

[69]  K. Klepárník,et al.  Analyte transport in liquid junction nano‐electrospray interface between capillary electrophoresis and mass spectrometry , 2010, Electrophoresis.

[70]  A replaceable microreactor for on-line protein digestion in a two-dimensional capillary electrophoresis system with tandem mass spectrometry detection. , 2011, Journal of chromatography. A.

[71]  Guonan Chen,et al.  Determination of stimulants and narcotics as well as their in vitro metabolites by online CE‐ESI‐MS , 2011, Electrophoresis.

[72]  H. Mischak,et al.  Performance of different separation methods interfaced in the same MS‐reflection TOF detector: A comparison of performance between CE versus HPLC for biomarker analysis , 2012, Electrophoresis.

[73]  Efforts to improve detection sensitivity for capillary electrophoresis coupled to atmospheric pressure photoionization mass spectrometry. , 2010, Rapid communications in mass spectrometry : RCM.

[74]  Leslie Y Yeo,et al.  Microfluidic devices for bioapplications. , 2011, Small.

[75]  J. Veuthey,et al.  Use of organic solvent to prevent protein adsorption in CE‐MS experiments , 2010, Electrophoresis.

[76]  C. Ionescu,et al.  Characterization of metal glycinate complexes by electrospray Q-TOF-MS/MS and their determination by capillary electrophoresis–ICP-MS: application to premix samples , 2010, Analytical and bioanalytical chemistry.

[77]  F. Matysik,et al.  Fast capillary electrophoresis–time-of-flight mass spectrometry using capillaries with inner diameters ranging from 75 to 5 μm , 2011, Analytical and bioanalytical chemistry.

[78]  R. Kostiainen,et al.  Microchip capillary electrophoresis-electrospray ionization-mass spectrometry of intact proteins using uncoated Ormocomp microchips. , 2012, Analytica chimica acta.

[79]  J. Kałużna-Czaplińska.  Current medical research with the application of coupled techniques with mass spectrometry , 2011, Medical science monitor : international medical journal of experimental and clinical research.

[80]  D. Harvey.  Derivatization of carbohydrates for analysis by chromatography; electrophoresis and mass spectrometry. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[81]  Feng Xiang,et al.  Advancing matrix-assisted laser desorption/ionization-mass spectrometric imaging for capillary electrophoresis analysis of peptides. , 2011, Analytical chemistry.

[82]  S. Müller,et al.  High resolution microbial single cell analytics , 2011 .

[83]  P. Boček,et al.  Recent advances in CE‐MS: Synergy of wet chemistry and instrumentation innovations , 2011, Electrophoresis.

[84]  S. Fanali,et al.  Advances in the enantioseparation of β‐blocker drugs by capillary electromigration techniques , 2011, Electrophoresis.

[85]  I. Messana,et al.  Analysis of arginine and methylated metabolites in human plasma by field amplified sample injection capillary electrophoresis tandem mass spectrometry , 2010, Electrophoresis.

[86]  K. Hayakawa,et al.  Analysis of Phosphorus-containing Amino Acid-type Herbicides by Sheathless Capillary Electrophoresis/Electrospray Ionization-Mass Spectrometry Using a High Sensitivity Porous Sprayer , 2011, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[87]  S. Ongay,et al.  Evaluation of the effect of the immunopurification‐based procedures on the CZE‐UV and CZE‐ESI‐TOF‐MS determination of isoforms of intact α‐1‐acid glycoprotein from human serum , 2010, Electrophoresis.

[88]  Christy L Haynes,et al.  Bioanalytical tools for single-cell study of exocytosis , 2010, Analytical and bioanalytical chemistry.

[89]  C. Neusüss,et al.  Statistical evaluation of CZE‐UV and CZE‐ESI‐MS data of intact α‐1‐acid glycoprotein isoforms for their use as potential biomarkers in bladder cancer , 2010, Electrophoresis.

[90]  Masaru Tomita,et al.  Prediction of metabolite identity from accurate mass, migration time prediction and isotopic pattern information in CE‐TOFMS data , 2010, Electrophoresis.

[91]  Guonan Chen,et al.  Analysis of ultratrace triorganotin compounds in aquatic organisms by using capillary electrophoresis-inductively coupled plasma mass spectrometry. , 2010, Talanta.

[92]  C. Huck,et al.  CE coupled to MALDI with novel covalently coated capillaries , 2010, Electrophoresis.

[93]  R. Kok,et al.  Characterization of drug-lysozyme conjugates by sheathless capillary electrophoresis-time-of-flight mass spectrometry. , 2011, Analytica chimica acta.

[94]  Feng Xiang,et al.  Combining capillary electrophoresis matrix-assisted laser desorption/ionization mass spectrometry and stable isotopic labeling techniques for comparative crustacean peptidomics. , 2010, Journal of chromatography. A.

[95]  Vojtech Adam,et al.  Vertebrate metallothioneins as target molecules for analytical techniques , 2010 .

[96]  Amjad Khan,et al.  Ionization techniques in capillary electrophoresis-mass spectrometry: principles, design, and application. , 2011, Mass spectrometry reviews.

[97]  F. Iavarone,et al.  Capillary electrophoresis-mass spectrometry for the analysis of amino acids. , 2010, Journal of separation science.

[98]  Shuai Sherry Zhao,et al.  Atmospheric pressure ion lens extends the stable operational region of an electrospray ion source for capillary electrophoresis‐mass spectrometry , 2012, Electrophoresis.

[99]  Y. Mechref.  Analysis of glycans derived from glycoconjugates by capillary electrophoresis‐mass spectrometry , 2011, Electrophoresis.

[100]  H. Mischak,et al.  CE‐MS in biomarker discovery, validation, and clinical application , 2011, Proteomics. Clinical applications.

[101]  Shiuh-Jen Jiang,et al.  Speciation analysis of arsenic and selenium compounds by CE‐dynamic reaction cell‐ICP‐MS , 2010, Electrophoresis.

[102]  J. Sweedler,et al.  Metabolic differentiation of neuronal phenotypes by single-cell capillary electrophoresis-electrospray ionization-mass spectrometry. , 2011, Analytical chemistry.

[103]  K. Otsuka,et al.  Recent progress in microchip electrophoresis-mass spectrometry. , 2011, Journal of pharmaceutical and biomedical analysis.

[104]  Jonathan V Sweedler,et al.  Label-free quantitation of peptide release from neurons in a microfluidic device with mass spectrometry imaging. , 2012, Lab on a chip.

[105]  J. Barbosa,et al.  Capillary electrophoresis time-of-flight mass spectrometry for a confident elucidation of a glycopeptide map of recombinant human erythropoietin. , 2011, Rapid communications in mass spectrometry : RCM.

[106]  Yong Luo,et al.  Towards single-cell analysis for pharmacokinetics. , 2012, Bioanalysis.

[107]  W. Thormann,et al.  Confirmation analysis of ethyl glucuronide and ethyl sulfate in human serum and urine by CZE‐ESI‐MSn after intake of alcoholic beverages , 2011, Electrophoresis.

[108]  Xuefei Sun,et al.  Membrane-based emitter for coupling microfluidics with ultrasensitive nanoelectrospray ionization-mass spectrometry. , 2011, Analytical chemistry.

[109]  A. Eckhardt,et al.  Non-enzymatic posttranslational modifications of bovine serum albumin by oxo-compounds investigated by high-performance liquid chromatography-mass spectrometry and capillary zone electrophoresis-mass spectrometry. , 2010, Journal of chromatography. A.

[110]  J. Rossier,et al.  Multi-Track Single- and Dual-Channel Plastic Microchips for Electrospray Mass Spectrometry , 2010, European journal of mass spectrometry.

[111]  N. Dovichi,et al.  Simplified capillary electrophoresis nanospray sheath-flow interface for high efficiency and sensitive peptide analysis. , 2010, Rapid communications in mass spectrometry : RCM.

[112]  C. García-Ruiz,et al.  Recent approaches for enhancing sensitivity in enantioseparations by CE , 2010, Electrophoresis.

[113]  V. R. Robledo,et al.  Advantages of using a modified orthogonal sampling configuration originally designed for LC-ESI-MS to couple CE and MS for the determination of antioxidant phenolic compounds found in virgin olive oil. , 2010, Talanta.

[114]  R. Kostiainen,et al.  Feasibility of SU‐8‐based capillary electrophoresis‐electrospray ionization mass spectrometry microfluidic chips for the analysis of human cell lysates , 2010, Electrophoresis.

[115]  Richard D. Smith,et al.  Mass spectrometry-based proteomics: existing capabilities and future directions. , 2012, Chemical Society reviews.

[116]  Angelina Taichrib,et al.  Multivariate statistics for the differentiation of erythropoietin preparations based on intact glycoforms determined by CE-MS , 2012, Analytical and Bioanalytical Chemistry.

[117]  R. Kostiainen,et al.  Rapid and sensitive drug metabolism studies by SU-8 microchip capillary electrophoresis-electrospray ionization mass spectrometry. , 2011, Journal of chromatography. A.

[118]  J. Barbosa,et al.  Transient isotachophoresis in on‐line solid phase extraction capillary electrophoresis time‐of‐flight‐mass spectrometry for peptide analysis in human plasma , 2011, Electrophoresis.

[119]  L. Suntornsuk.  Recent advances of capillary electrophoresis in pharmaceutical analysis , 2010, Analytical and bioanalytical chemistry.

[120]  S. Fanali,et al.  Simultaneous analysis of cocaine and its metabolites in urine by capillary electrophoresis–electrospray mass spectrometry using a pressurized liquid junction nanoflow interface , 2012, Electrophoresis.

[121]  L. R. Ruhaak,et al.  Glycan labeling strategies and their use in identification and quantification , 2010, Analytical and bioanalytical chemistry.

[122]  S. Ongay,et al.  Isoform differentiation of intact AGP from human serum by capillary electrophoresis–mass spectrometry , 2010, Analytical and bioanalytical chemistry.

[123]  K. Inagaki,et al.  Quantification of phosphorus in DNA using capillary electrophoresis hyphenated with inductively coupled plasma mass spectrometry. , 2010, Journal of chromatography. A.

[124]  P. Haddad,et al.  Complexation of metals by phytosiderophores revealed by CE‐ESI‐MS and CE‐ICP‐MS , 2010, Electrophoresis.

[125]  A. Timperman,et al.  A Study of Electrospray Ionization Emitters with Differing Geometries with Respect to Flow Rate and Electrospray Voltage , 2011, Journal of the American Society for Mass Spectrometry.

[126]  R. Zenobi,et al.  Analytical techniques for single-cell metabolomics: state of the art and trends , 2010, Analytical and bioanalytical chemistry.

[127]  A. Timperman,et al.  Analyte transport past a nanofluidic intermediate electrode junction in a microfluidic device , 2010, Electrophoresis.

[128]  E. Ban,et al.  Growing trend of CE at the omics level: The frontier of systems biology – An update , 2012, Electrophoresis.

[129]  A. Capriotti,et al.  Intact protein separation by chromatographic and/or electrophoretic techniques for top-down proteomics. , 2011, Journal of chromatography. A.

[130]  E. Ban,et al.  Sensitivity enhancement of CE and CE-MS for the analysis of peptides by a dynamic pH junction. , 2010, Journal of separation science.

[131]  R. Ramautar,et al.  Relevance and use of capillary coatings in capillary electrophoresis–mass spectrometry , 2010, Analytical and bioanalytical chemistry.

[132]  A. Cifuentes,et al.  CE‐TOF MS analysis of complex protein hydrolyzates from genetically modified soybeans – A tool for foodomics , 2010, Electrophoresis.

[133]  Yan Li,et al.  Label-free DNA hybridization detection and single base-mismatch discrimination using CE-ICP-MS assay. , 2011, The Analyst.

[134]  Yongning Wu,et al.  Speciation analysis of mercury in natural water and fish samples by using capillary electrophoresis-inductively coupled plasma mass spectrometry. , 2012, Talanta.

[135]  G. Jiang,et al.  Speciation of organotin compounds in environmental samples with semi-permanent coated capillaries by capillary electrophoresis coupled with inductively coupled plasma mass spectrometry , 2010 .

[136]  Massimo Castagnola,et al.  Capillary electrophoresis--mass spectrometry: recent trends in clinical proteomics. , 2010, Journal of pharmaceutical and biomedical analysis.

[137]  Matthias Heinemann,et al.  Single cell metabolomics. , 2011, Current opinion in biotechnology.

[138]  P. Britz‐McKibbin,et al.  Metabolomic studies of radiation‐induced apoptosis of human leukocytes by capillary electrophoresis‐mass spectrometry and flow cytometry: Adaptive cellular responses to ionizing radiation , 2010, Electrophoresis.

[139]  Sanjeewa Gamagedara,et al.  Biomarker analysis for prostate cancer diagnosis using LC-MS and CE-MS. , 2011, Bioanalysis.

[140]  D. Chiu.  Interfacing droplet microfluidics with chemical separation for cellular analysis , 2010, Analytical and bioanalytical chemistry.

[141]  E. Maxwell,et al.  Flow-through microvial facilitating interface of capillary isoelectric focusing and electrospray ionization mass spectrometry. , 2011, Analytical chemistry.

[142]  Liangjun Xu,et al.  Simultaneous and ultra-sensitive quantification of multiple peptides by using europium chelate labeling and capillary electrophoresis-inductively coupled plasma mass spectrometry , 2012 .

[143]  G. J. Jong,et al.  In-line solid-phase extraction–capillary electrophoresis coupled with mass spectrometry for determination of drugs of abuse in human urine , 2012, Analytical and Bioanalytical Chemistry.

[144]  G. D. de Jong,et al.  Sensitivity enhancement in capillary electrophoresis‐mass spectrometry of anionic metabolites using a triethylamine‐containing background electrolyte and sheath liquid , 2011, Electrophoresis.

[145]  J. Bergquist,et al.  A method for quantitative analysis of an anticancer drug in human plasma with CE‐ESI‐TOF‐MS , 2011, Electrophoresis.

[146]  Xiu‐Ping Yan,et al.  Gold nanoparticles amplified ultrasensitive quantification of human urinary protein by capillary electrophoresis with on-line inductively coupled plasma mass spectroscopic detection. , 2010, Journal of proteome research.

[147]  H. Gruppen,et al.  CE‐LIF‐MSn profiling of oligosaccharides in human milk and feces of breast‐fed babies , 2010, Electrophoresis.

[148]  Shigeki Kajihara,et al.  Anal Bioanal Chem (2011) 400:1895–1904 DOI 10.1007/s00216-011-4895-5 ORIGINAL PAPER , 2022 .

[149]  H. Girault,et al.  High‐sensitive protein analysis by FESI‐CE‐MALDI‐MS , 2011, Electrophoresis.

[150]  A. M. García-Campaña,et al.  Capillary electrophoresis for the analysis of drugs of abuse in biological specimens of forensic interest , 2012 .

[151]  J. Veuthey,et al.  Analysis of hemoglobin‐based oxygen carriers by CE‐UV/Vis and CE‐ESI‐TOF/MS , 2010, Electrophoresis.

[152]  B. Sarg,et al.  Optimization and evaluation of a sheathless capillary electrophoresis-electrospray ionization mass spectrometry platform for peptide analysis: comparison to liquid chromatography-electrospray ionization mass spectrometry. , 2011, Analytical chemistry.

[153]  T. Rejtar,et al.  Improved sample preparation method for glycan analysis of glycoproteins by CE‐LIF and CE‐MS , 2010, Electrophoresis.

[154]  I. Lazar,et al.  Recent advances in the MS analysis of glycoproteins: Capillary and microfluidic workflows , 2011, Electrophoresis.

[155]  Xuefei Sun,et al.  Ultrasensitive nanoelectrospray ionization-mass spectrometry using poly(dimethylsiloxane) microchips with monolithically integrated emitters. , 2010, The Analyst.

[156]  E. Maxwell,et al.  Asymmetrical emitter geometries for increased range of stable electrospray flow rates. , 2010, Analytical chemistry.

[157]  A. Oikawa,et al.  Metabolite analyses of single cells. , 2012, The Plant journal : for cell and molecular biology.

[158]  G. D. de Jong,et al.  Capillary electrophoresis–mass spectrometry for the analysis of intact proteins 2007–2010 , 2011, Electrophoresis.

[159]  F. Matysik,et al.  Fast separations by capillary electrophoresis hyphenated to electrospray ionization time-of-flight mass spectrometry as a tool for arsenic speciation analysis. , 2012, The Analyst.

[160]  A. Wagner,et al.  Capillary electrophoresis-inductively coupled plasma-mass spectrometry hyphenation for the determination at the nanogram scale of metal affinities and binding constants of phosphorylated ligands. , 2012, Journal of chromatography. A.

[161]  E. Maxwell,et al.  Mass transport in a micro flow-through vial of a junction-at-the-tip capillary electrophoresis-mass spectrometry interface. , 2011, Analytical chemistry.

[162]  M. Potin-Gautier,et al.  Investigation of uranium-colloid interactions in soil by dual field-flow fractionation/capillary electrophoresis hyphenated with inductively coupled plasma-mass spectrometry. , 2011, Talanta.

[163]  R. Zare,et al.  Microfluidic platforms for single-cell analysis. , 2010, Annual review of biomedical engineering.

[164]  A. Cifuentes,et al.  Is metabolomics reachable? Different purification strategies of human colon cancer cells provide different CE‐MS metabolite profiles , 2011, Electrophoresis.

[165]  J. Preisler,et al.  Off-line coupling of microcolumn separations to desorption mass spectrometry. , 2010, Journal of chromatography. A.

[166]  A. Timerbaev.  Inorganic species analysis by CE – An overview for 2007–2008 , 2010, Electrophoresis.

[167]  M. MacCoss,et al.  Capillary electrophoresis with Orbitrap-Velos mass spectrometry detection. , 2012, Talanta.

[168]  Shaorong Liu,et al.  Coupling sodium dodecyl sulfate-capillary polyacrylamide gel electrophoresis with matrix-assisted laser desorption ionization time-of-flight mass spectrometry via a poly(tetrafluoroethylene) membrane. , 2011, Analytical chemistry.

[169]  Xiuzhong Wang,et al.  A simple and demountable capillary microflow nebulizer with a tapered tip for inductively coupled plasma mass spectrometry. , 2011, Talanta.

[170]  M. Wink,et al.  Determination of quinolizidine alkaloids in different Lupinus species by NACE using UV and MS detection. , 2010, Journal of pharmaceutical and biomedical analysis.

[171]  V. Adam,et al.  Analysis of metallothionein by capillary electrophoresis. , 2012, Journal of chromatography. A.

[172]  E. Carrilho,et al.  CE‐MS and related techniques as a valuable tool in tumor biomarkers research , 2010, Electrophoresis.

[173]  C. Klampfl,et al.  Investigations on the Influence of Interface-Geometry in CE-ESI-TOF-MS , 2010 .