Attention modulates responses in the human lateral geniculate nucleus

Attentional mechanisms are important for selecting relevant information and filtering out irrelevant information from cluttered visual scenes. Selective attention has previously been shown to affect neural activity in both extrastriate and striate visual cortex. Here, evidence from functional brain imaging shows that attentional response modulation is not confined to cortical processing, but can occur as early as the thalamic level. We found that attention modulated neural activity in the human lateral geniculate nucleus (LGN) in several ways: it enhanced neural responses to attended stimuli, attenuated responses to ignored stimuli and increased baseline activity in the absence of visual stimulation. The LGN, traditionally viewed as the gateway to visual cortex, may also serve as a 'gatekeeper' in controlling attentional response gain.

[1]  G Mann,et al.  ON THE THALAMUS * , 1905, British medical journal.

[2]  F. Crick.  Function of the thalamic reticular complex: the searchlight hypothesis. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[3]  S Ullman,et al.  Shifts in selective visual attention: towards the underlying neural circuitry. , 1985, Human neurobiology.

[4]  R. Desimone,et al.  Selective attention gates visual processing in the extrastriate cortex. , 1985, Science.

[5]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[6]  M Corbetta,et al.  Attentional modulation of neural processing of shape, color, and velocity in humans. , 1990, Science.

[7]  F C Hoppensteadt,et al.  The searchlight hypothesis , 1991, Journal of mathematical biology.

[8]  Richard S. J. Frackowiak,et al.  Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. , 1993, Cerebral cortex.

[9]  B. C. Motter.  Focal attention produces spatially selective processing in visual cortical areas V1, V2, and V4 in the presence of competing stimuli. , 1993, Journal of neurophysiology.

[10]  J. Mazziotta,et al.  MRI‐PET Registration with Automated Algorithm , 1993, Journal of computer assisted tomography.

[11]  Y. Tsal,et al.  Perceptual load as a major determinant of the locus of selection in visual attention , 1994, Perception & psychophysics.

[12]  Karl J. Friston,et al.  Analysis of fMRI Time-Series Revisited , 1995, NeuroImage.

[13]  J W Belliveau,et al.  Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. , 1995, Science.

[14]  R. Desimone,et al.  Neural mechanisms of selective visual attention. , 1995, Annual review of neuroscience.

[15]  J H Maunsell,et al.  The Brain's Visual World: Representation of Visual Targets in Cerebral Cortex , 1995, Science.

[16]  M. Goldberg,et al.  Visual, presaccadic, and cognitive activation of single neurons in monkey lateral intraparietal area. , 1996, Journal of neurophysiology.

[17]  R. Desimone,et al.  Neural mechanisms of spatial selective attention in areas V1, V2, and V4 of macaque visual cortex. , 1997, Journal of neurophysiology.

[18]  C D Frith,et al.  Modulating irrelevant motion perception by varying attentional load in an unrelated task. , 1997, Science.

[19]  Leslie G. Ungerleider,et al.  Mechanisms of directed attention in the human extrastriate cortex as revealed by functional MRI. , 1998, Science.

[20]  R. Guillery,et al.  Paying attention to the thalamic reticular nucleus , 1998, Trends in Neurosciences.

[21]  Alexander M. Harner,et al.  Task-dependent influences of attention on the activation of human primary visual cortex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[22]  P. Cavanagh,et al.  Retinotopy and color sensitivity in human visual cortical area V8 , 1998, Nature Neuroscience.

[23]  Seiji Ogawa,et al.  Mapping of lateral geniculate nucleus activation during visual stimulation in human brain using fMRI , 1998, Magnetic resonance in medicine.

[24]  Leslie G. Ungerleider,et al.  Increased Activity in Human Visual Cortex during Directed Attention in the Absence of Visual Stimulation , 1999, Neuron.

[25]  K. Uğurbil,et al.  Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C. Gilbert,et al.  Attention and primary visual cortex. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[27]  C. Gilbert,et al.  Attention Modulates Contextual Influences in the Primary Visual Cortex of Alert Monkeys , 1999, Neuron.

[28]  S. Hillyard,et al.  Involvement of striate and extrastriate visual cortical areas in spatial attention , 1999, Nature Neuroscience.

[29]  D. Somers,et al.  Functional MRI reveals spatially specific attentional modulation in human primary visual cortex. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[30]  D. Heeger,et al.  Spatial attention affects brain activity in human primary visual cortex. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[31]  N. Kanwisher,et al.  Visual attention: Insights from brain imaging , 2000, Nature Reviews Neuroscience.

[32]  G A Orban,et al.  Attention-dependent suppression of metabolic activity in the early stages of the macaque visual system. , 2000, Cerebral cortex.

[33]  D. Heeger,et al.  Activity in primary visual cortex predicts performance in a visual detection task , 2000, Nature Neuroscience.

[34]  R. Guillery,et al.  Exploring the Thalamus , 2000 .

[35]  C. Schroeder,et al.  Intermodal selective attention in monkeys. I: distribution and timing of effects across visual areas. , 2000, Cerebral cortex.

[36]  Leslie G. Ungerleider,et al.  Mechanisms of visual attention in the human cortex. , 2000, Annual review of neuroscience.

[37]  C. Schroeder,et al.  Intermodal selective attention in monkeys. II: physiological mechanisms of modulation. , 2000, Cerebral cortex.

[38]  D. B. Bender,et al.  Effect of attentive fixation in macaque thalamus and cortex. , 2001, Journal of neurophysiology.

[39]  Leslie G. Ungerleider,et al.  Modulation of sensory suppression: implications for receptive field sizes in the human visual cortex. , 2001, Journal of neurophysiology.

[40]  N. Logothetis,et al.  Neurophysiological investigation of the basis of the fMRI signal , 2001, Nature.

[41]  S. Sherman.  Tonic and burst firing: dual modes of thalamocortical relay , 2001, Trends in Neurosciences.

[42]  R. Guillery,et al.  Thalamic Relay Functions and Their Role in Corticocortical Communication Generalizations from the Visual System , 2002, Neuron.

[43]  R. Reid,et al.  Saccadic Eye Movements Modulate Visual Responses in the Lateral Geniculate Nucleus , 2002, Neuron.