Effects of oral administration of rotenone on gastrointestinal functions in mice

Background  The systemic rotenone model of Parkinson’s disease (PD) accurately replicates many aspects of the pathology of human PD, especially neurodegeneration of the substantia nigra and lesions in the enteric nervous system (ENS). Nevertheless, the precise effects of oral rotenone on the ENS have not been addressed yet. This study was therefore designed to assess the effects of a chronic oral treatment by rotenone on enteric neurochemical phenotype, gastrointestinal (GI) motility, and intestinal epithelial barrier permeability.

[1]  O. Suchowersky,et al.  Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg? , 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[2]  P. Derkinderen,et al.  Parkinson Disease: The Enteric Nervous System Spills its Guts , 2012, Neurology.

[3]  S. B. des Varannes,et al.  Diet‐induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line‐derived neurotrophic factor , 2012, The Journal of physiology.

[4]  Jeffrey H. Kordower,et al.  Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease , 2011, PloS one.

[5]  K. Krogh.  Gastrointestinal Dysfunction in Parkinson’s Disease , 2011 .

[6]  M. Rolli-Derkinderen,et al.  n–3 polyunsaturated fatty acids in the maternal diet modify the postnatal development of nervous regulation of intestinal permeability in piglets , 2011, The Journal of physiology.

[7]  C. Tanner,et al.  Rotenone, Paraquat, and Parkinson’s Disease , 2011, Environmental health perspectives.

[8]  J. Söderholm,et al.  Importance of disrupted intestinal barrier in inflammatory bowel diseases , 2011, Inflammatory bowel diseases.

[9]  F. Fornai,et al.  MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut , 2010, Brain Research.

[10]  Franz Hefti,et al.  Paraquat and Parkinson's disease , 1986, Neurology.

[11]  H. Shill,et al.  Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders , 2010, Acta Neuropathologica.

[12]  H. Reichmann,et al.  Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice , 2010, PloS one.

[13]  G. Nappi,et al.  Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease , 2009, Neuroscience Letters.

[14]  L. Montero,et al.  Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology , 2009, Neurobiology of Disease.

[15]  C. Duyckaerts,et al.  The second brain and Parkinson’s disease , 2009, The European journal of neuroscience.

[16]  S. Srinivasan,et al.  Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease , 2009, Experimental Neurology.

[17]  E. Bézard,et al.  Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[18]  E. Hirsch,et al.  Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. , 2008, The Journal of clinical investigation.

[19]  T. Savidge,et al.  Neuro‐glial crosstalk in inflammatory bowel disease , 2008, Journal of internal medicine.

[20]  Ding-zhen Luo,et al.  Alteration of dopaminergic markers in gastrointestinal tract of different rodent models of Parkinson's disease , 2008, Neuroscience.

[21]  H. Braak,et al.  Parkinson's disease: a dual‐hit hypothesis , 2007, Neuropathology and applied neurobiology.

[22]  S. Srinivasan,et al.  Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease , 2007, Experimental Neurology.

[23]  M. Sofroniew,et al.  Starring roles for astroglia in barrier pathologies of gut and brain , 2007, Laboratory Investigation.

[24]  Kazuyuki Takata,et al.  Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4‐phenylbutyrate, a chemical chaperone , 2007, Journal of neurochemistry.

[25]  Gary W Miller,et al.  Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease , 2007, Journal of neurochemistry.

[26]  P. Trend,et al.  Excess burden of constipation in Parkinson's disease: A pilot study , 2006, Movement disorders : official journal of the Movement Disorder Society.

[27]  H. Braak,et al.  Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology , 2006, Neuroscience Letters.

[28]  J. Galmiche,et al.  Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption , 2005, Gut.

[29]  M. Neunlist,et al.  The human enteric nervous system , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[30]  Todd B. Sherer,et al.  Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.

[31]  Heidi Phillips,et al.  Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.

[32]  K. Miyata,et al.  Compounds possessing 5-HT3 receptor antagonistic activity inhibit intestinal propulsion in mice. , 1996, European journal of pharmacology.

[33]  E. Quigley.  Gastrointestinal Dysfunction in Parkinson's Disease , 1996, Seminars in neurology.

[34]  E. Hirsch,et al.  The rotenone model of parkinsonism--the five years inspection. , 2006, Journal of neural transmission. Supplementum.

[35]  D. Sulzer,et al.  Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. , 2000, Neuron.

[36]  E. Gaumnitz,et al.  Peripheral and central actions of orphanin FQ (nociceptin) on murine colon. , 1999, American journal of physiology. Gastrointestinal and liver physiology.