Most cited articles in the Archives of Toxicology: the debate about possibilities and limitations of in vitro toxicity tests and replacement of in vivo studies
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[1] J. G. Hengstler,et al. Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH) , 2008, Archives of Toxicology.
[2] J. Hengstler,et al. Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers , 2007, Hepatology.
[3] Pilju Youn,et al. Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake , 2007, Archives of Toxicology.
[4] Sarita Gupta,et al. Effect of co-exposure to lead and cadmium on antioxidant status in rat ovarian granulose cells , 2007, Archives of Toxicology.
[5] S. Chakrabarti,et al. Role of oxidative stress and intracellular calcium in nickel carbonate hydroxide-induced sister-chromatid exchange, and alterations in replication index and mitotic index in cultured human peripheral blood lymphocytes , 2007, Archives of Toxicology.
[6] Hayley S. Brown,et al. Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies , 2007, Drug metabolism reviews.
[7] J. Tanus-Santos,et al. A polymorphism in the delta-aminolevulinic acid dehydratase gene modifies plasma/whole blood lead ratio , 2006, Archives of Toxicology.
[8] Hui-Hsuan Lin,et al. Immunohistochemical Detection of Apoptotic Proteins, p53/Bax and JNK/FasL Cascade, in the Lung of Rats Exposed to Cigarette Smoke , 2006, Archives of Toxicology.
[9] J. Tanus-Santos,et al. Clinical evidence for lead-induced inhibition of nitric oxide formation , 2006, Archives of Toxicology.
[10] J. Fink-Gremmels,et al. Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells , 2006, Archives of Toxicology.
[11] F. Fonnum,et al. Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro , 2006, Archives of Toxicology.
[12] J. Tanus-Santos,et al. Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects , 2006, Archives of Toxicology.
[13] Zhihong Liu,et al. Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro , 2006, Archives of Toxicology.
[14] P. Bernardi,et al. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening , 2006, Archives of Toxicology.
[15] K. Mitsumori,et al. Possible involvement of oxidative stress in dicyclanil-induced hepatocarcinogenesis in mice , 2006, Archives of Toxicology.
[16] P. Aas,et al. Anticonvulsant effects of GABAA modulators microinfused into area tempestas or substantia nigra in rats exposed to soman , 2006, Archives of Toxicology.
[17] C. Chou,et al. Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release , 2006, Archives of Toxicology.
[18] Zi-rong Xu,et al. Evaluation of caspase-dependent apoptosis during fluoride-induced liver lesion in pigs , 2006, Archives of Toxicology.
[19] J. Angerer,et al. Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide , 2006, Archives of Toxicology.
[20] J. Y. Liu,et al. Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells , 2006, Archives of Toxicology.
[21] Helmut Greim,et al. Toxicological comments to the discussion about REACH , 2006, Archives of Toxicology.
[22] F. Oesch,et al. Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. , 2005, Toxicology.
[23] F. Oesch,et al. New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures , 2003, Drug metabolism reviews.
[24] F. Oesch,et al. CRYOPRESERVED PRIMARY HEPATOCYTES AS A CONSTANTLY AVAILABLE IN VITRO MODEL FOR THE EVALUATION OF HUMAN AND ANIMAL DRUG METABOLISM AND ENZYME INDUCTION* , 2000, Drug metabolism reviews.
[25] T. Brüning,et al. Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study , 2006, Archives of Toxicology.
[26] C. Spiliopoulou,et al. Zinc: a multipurpose trace element , 2005, Archives of Toxicology.