Most cited articles in the Archives of Toxicology: the debate about possibilities and limitations of in vitro toxicity tests and replacement of in vivo studies

[1]  J. G. Hengstler,et al.  Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH) , 2008, Archives of Toxicology.

[2]  J. Hengstler,et al.  Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers , 2007, Hepatology.

[3]  Pilju Youn,et al.  Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake , 2007, Archives of Toxicology.

[4]  Sarita Gupta,et al.  Effect of co-exposure to lead and cadmium on antioxidant status in rat ovarian granulose cells , 2007, Archives of Toxicology.

[5]  S. Chakrabarti,et al.  Role of oxidative stress and intracellular calcium in nickel carbonate hydroxide-induced sister-chromatid exchange, and alterations in replication index and mitotic index in cultured human peripheral blood lymphocytes , 2007, Archives of Toxicology.

[6]  Hayley S. Brown,et al.  Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies , 2007, Drug metabolism reviews.

[7]  J. Tanus-Santos,et al.  A polymorphism in the delta-aminolevulinic acid dehydratase gene modifies plasma/whole blood lead ratio , 2006, Archives of Toxicology.

[8]  Hui-Hsuan Lin,et al.  Immunohistochemical Detection of Apoptotic Proteins, p53/Bax and JNK/FasL Cascade, in the Lung of Rats Exposed to Cigarette Smoke , 2006, Archives of Toxicology.

[9]  J. Tanus-Santos,et al.  Clinical evidence for lead-induced inhibition of nitric oxide formation , 2006, Archives of Toxicology.

[10]  J. Fink-Gremmels,et al.  Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells , 2006, Archives of Toxicology.

[11]  F. Fonnum,et al.  Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro , 2006, Archives of Toxicology.

[12]  J. Tanus-Santos,et al.  Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects , 2006, Archives of Toxicology.

[13]  Zhihong Liu,et al.  Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro , 2006, Archives of Toxicology.

[14]  P. Bernardi,et al.  High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening , 2006, Archives of Toxicology.

[15]  K. Mitsumori,et al.  Possible involvement of oxidative stress in dicyclanil-induced hepatocarcinogenesis in mice , 2006, Archives of Toxicology.

[16]  P. Aas,et al.  Anticonvulsant effects of GABAA modulators microinfused into area tempestas or substantia nigra in rats exposed to soman , 2006, Archives of Toxicology.

[17]  C. Chou,et al.  Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release , 2006, Archives of Toxicology.

[18]  Zi-rong Xu,et al.  Evaluation of caspase-dependent apoptosis during fluoride-induced liver lesion in pigs , 2006, Archives of Toxicology.

[19]  J. Angerer,et al.  Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide , 2006, Archives of Toxicology.

[20]  J. Y. Liu,et al.  Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells , 2006, Archives of Toxicology.

[21]  Helmut Greim,et al.  Toxicological comments to the discussion about REACH , 2006, Archives of Toxicology.

[22]  F. Oesch,et al.  Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. , 2005, Toxicology.

[23]  F. Oesch,et al.  New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures , 2003, Drug metabolism reviews.

[24]  F. Oesch,et al.  CRYOPRESERVED PRIMARY HEPATOCYTES AS A CONSTANTLY AVAILABLE IN VITRO MODEL FOR THE EVALUATION OF HUMAN AND ANIMAL DRUG METABOLISM AND ENZYME INDUCTION* , 2000, Drug metabolism reviews.

[25]  T. Brüning,et al.  Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study , 2006, Archives of Toxicology.

[26]  C. Spiliopoulou,et al.  Zinc: a multipurpose trace element , 2005, Archives of Toxicology.