Regulation of neutrophil extracellular traps in cancer

Neutrophil extracellular trap (NET) is one of the defense functions of neutrophils, which has a rapid ability to kill infections and is also crucial in a variety of immune-associated diseases including infections, tumors and autoimmune diseases. Recent studies have shown that NETs are closely related to the development of tumors. The regulatory role of NETs in tumors has been of interest to researchers. In addition to awakening latent tumor cells, NETs can also promote the proliferation and development of tumor cells and their metastasis to other sites. At the same time, NETs also have the effect of inhibiting tumors. At present, there are some new advances in the impact of NETs on tumor development, which will provide a more theoretical basis for developing NET-targeted drugs. Therefore, this review just summarized the formation process of NETs, the regulation of tumor development and the treatment methods based on NETs.

[1]  X. Zou,et al.  Neutrophil extracellular traps promote angiogenesis in gastric cancer , 2023, Cell Communication and Signaling.

[2]  Wei Zhou,et al.  Neutrophil extracellular traps mediate TLR9/Merlin axis to resist ferroptosis and promote triple negative breast cancer progression , 2023, Apoptosis.

[3]  C. Weishaupt,et al.  Neutrophil Extracellular Traps Correlate with Tumor Necrosis and Size in Human Malignant Melanoma Metastases , 2023, Biology.

[4]  Jiajing Zhao,et al.  Prediction of prognosis and immunotherapy response in breast cancer based on neutrophil extracellular traps-related classification , 2023, Frontiers in Molecular Biosciences.

[5]  Binbin Wang,et al.  GSK484, an inhibitor of peptidyl arginine deiminase 4, increases the radiosensitivity of colorectal cancer and inhibits neutrophil extracellular traps , 2023, The journal of gene medicine.

[6]  Hong Li,et al.  Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer. , 2023, International immunopharmacology.

[7]  Songlin Hou,et al.  [Neutrophil extracellular traps activates focal adhesion kinase by upregulating MMP9 expression to promote proliferation and migration of mouse colorectal cancer cells]. , 2023, Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.

[8]  Fan Yang,et al.  Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth , 2023, Cell Communication and Signaling.

[9]  X. Zou,et al.  Effect of NETs/COX-2 pathway on immune microenvironment and metastasis in gastric cancer , 2023, Frontiers in Immunology.

[10]  D. Spector,et al.  Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation. , 2023, Cancer cell.

[11]  Y. Miao,et al.  Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice. , 2023, Cancer letters.

[12]  Swneke D. Bailey,et al.  Tumour extracellular vesicles induce neutrophil extracellular traps to promote lymph node metastasis , 2023, bioRxiv.

[13]  Xuefeng Wu,et al.  Neutrophil extracellular traps as a unique target in the treatment of chemotherapy-induced peripheral neuropathy , 2023, EBioMedicine.

[14]  Wenxia Song,et al.  An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis , 2023, Drug delivery.

[15]  Yongming Chen,et al.  Nanoparticulate Cationic Poly(amino acid)s Block Cancer Metastases by Destructing Neutrophil Extracellular Traps. , 2023, ACS nano.

[16]  K. Obama,et al.  Neutrophil Extracellular Traps Promote Metastases of Colorectal Cancers through Activation of ERK Signaling by Releasing Neutrophil Elastase , 2023, International journal of molecular sciences.

[17]  M. Herrmann,et al.  No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment , 2022, Frontiers in Immunology.

[18]  Yong Huang,et al.  Elevated neutrophil extracellular traps by HBV‐mediated S100A9‐TLR4/RAGE‐ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma , 2022, Cancer communications.

[19]  Lisha Zhang,et al.  Immunoregulation and clinical significance of neutrophils/NETs-ANGPT2 in tumor microenvironment of gastric cancer , 2022, Frontiers in Immunology.

[20]  A. Bazhin,et al.  Neutrophil extracellular traps facilitate cancer metastasis: cellular mechanisms and therapeutic strategies , 2022, Journal of Cancer Research and Clinical Oncology.

[21]  Shih-Feng Yang,et al.  Neutrophil extracellular traps participate in the development of cancer-associated thrombosis in patients with gastric cancer , 2022, World journal of gastroenterology.

[22]  N. Sata,et al.  Neutrophil extracellular traps (NETs) reduce the diffusion of doxorubicin which may attenuate its ability to induce apoptosis of ovarian cancer cells , 2022, Heliyon.

[23]  E. Orenes-Piñero,et al.  Dual Effect of Immune Cells within Tumour Microenvironment: Pro- and Anti-Tumour Effects and Their Triggers , 2022, Cancers.

[24]  J. Spicer,et al.  Neutrophil Extracellular Traps in Cancer Therapy Resistance , 2022, Cancers.

[25]  D. Geller,et al.  Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment , 2021, Frontiers in Immunology.

[26]  G. Tetz,et al.  Neutrophil Extracellular Traps (NETs): Opportunities for Targeted Therapy , 2021, Acta naturae.

[27]  C. Shao,et al.  Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3 , 2021, Nature Communications.

[28]  J. I. Castañeda-Sánchez,et al.  Bacillus licheniformis and Bacillus subtilis, Probiotics That Induce the Formation of Macrophage Extracellular Traps , 2021, Microorganisms.

[29]  C. Garrido,et al.  Tumor-Derived Exosomes: Hidden Players in PD-1/PD-L1 Resistance , 2021, Cancers.

[30]  A. Tsung,et al.  Regulatory T cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis. , 2021, Journal of hepatology.

[31]  T. Billiar,et al.  Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress , 2021, Cancer Research.

[32]  James O. Jones,et al.  Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth , 2021, Nature Communications.

[33]  Q. Yang,et al.  Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. , 2020, Cancer cell.

[34]  P. Libby,et al.  Eosinophils improve cardiac function after myocardial infarction , 2020, Nature Communications.

[35]  M. Minopoli,et al.  The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis , 2020, Frontiers in Immunology.

[36]  V. Novakovic,et al.  Endothelial damage and a thin intercellular fibrin network promote haemorrhage in acute promyelocytic leukaemia , 2020, EBioMedicine.

[37]  A. Maitra,et al.  Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer , 2020, The Journal of experimental medicine.

[38]  D. Wagner,et al.  Cellular Mechanisms of NETosis. , 2020, Annual review of cell and developmental biology.

[39]  E. Song,et al.  DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25 , 2020, Nature.

[40]  Ping Wang,et al.  Extracellular CIRP and TREM‐1 axis promotes ICAM‐1‐Rho‐mediated NETosis in sepsis , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[41]  M. Carleton,et al.  CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity. , 2020, Immunity.

[42]  Dong Li,et al.  Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression , 2020, Cell Communication and Signaling.

[43]  A. Tsung,et al.  Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis , 2020, Molecular Cancer Research.

[44]  N. Beauchemin,et al.  Neutrophil Extracellular Trap–Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma , 2020, The Journal of Immunology.

[45]  G. Del Favero,et al.  Neutrophil Extracellular Trap Formation Correlates with Favorable Overall Survival in High Grade Ovarian Cancer , 2020, Cancers.

[46]  G. Marone,et al.  Anaplastic Thyroid Cancer Cells Induce the Release of Mitochondrial Extracellular DNA Traps by Viable Neutrophils , 2020, The Journal of Immunology.

[47]  T. Luger,et al.  Evidence and impact of neutrophil extracellular traps in malignant melanoma , 2020, Pigment cell & melanoma research.

[48]  J. Nelson,et al.  A Neutrophil Activation Biomarker Panel in Prognosis and Monitoring of Patients With Rheumatoid Arthritis , 2020, Arthritis & rheumatology.

[49]  A. Bengtsson,et al.  Role of Neutrophil Extracellular Traps Regarding Patients at Risk of Increased Disease Activity and Cardiovascular Comorbidity in Systemic Lupus Erythematosus , 2019, The Journal of Rheumatology.

[50]  A. Manda-Handzlik,et al.  The Brain Entangled: The Contribution of Neutrophil Extracellular Traps to the Diseases of the Central Nervous System , 2019, Cells.

[51]  D. Bartlett,et al.  Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth. , 2019, Cancer research.

[52]  M. Lotze,et al.  DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth , 2019, Oncoimmunology.

[53]  D. Wagner,et al.  NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture , 2019, Proceedings of the National Academy of Sciences.

[54]  Yan Li,et al.  Extracellular RNAs from lung cancer cells activate epithelial cells and induce neutrophil extracellular traps , 2019, International journal of oncology.

[55]  Yan Li,et al.  Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps , 2019, Oncology letters.

[56]  Limin Li,et al.  BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment. , 2019, Clinical immunology.

[57]  Dara R. Pabittei,et al.  Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time‐dependent manner during atherothrombosis , 2019, The Journal of pathology.

[58]  E. Lengyel,et al.  Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum , 2019, The Journal of experimental medicine.

[59]  P. Sun,et al.  Neutrophil Extracellular Traps Induced by IL8 Promote Diffuse Large B-cell Lymphoma Progression via the TLR9 Signaling , 2018, Clinical Cancer Research.

[60]  Michael S. Goldberg,et al.  Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice , 2018, Science.

[61]  David A. Williams,et al.  The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils , 2018, Science Signaling.

[62]  A. Tsung,et al.  Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis , 2018, Hepatology.

[63]  Yi He,et al.  Neutrophil Extracellular Traps in Autoimmune Diseases , 2018, Chinese medical journal.

[64]  Ping Wang,et al.  CIRP increases ICAM‐1+ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis , 2018, Journal of leukocyte biology.

[65]  A. Hamidi,et al.  Platelets, NETs and cancer. , 2018, Thrombosis research.

[66]  S. Marshall,et al.  Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease , 2018, The Journal of allergy and clinical immunology.

[67]  N. C. Rochael,et al.  Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis , 2017, Scientific Reports.

[68]  P. Metharom,et al.  Pancreatic Cancer-Induced Neutrophil Extracellular Traps: A Potential Contributor to Cancer-Associated Thrombosis , 2017, International Journal of Molecular Sciences.

[69]  Z. Lu,et al.  RNA Biomarkers: Frontier of Precision Medicine for Cancer , 2017, Non-coding RNA.

[70]  Michael S. Goldberg,et al.  Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps , 2016, Science Translational Medicine.

[71]  Matthieu Texier,et al.  Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination , 2016, Nature Reviews Clinical Oncology.

[72]  N. Borregaard,et al.  Neutrophil extracellular traps - the dark side of neutrophils. , 2016, The Journal of clinical investigation.

[73]  A. Tsung,et al.  Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress. , 2016, Cancer research.

[74]  D. Wagner,et al.  Priming of neutrophils toward NETosis promotes tumor growth , 2016, Oncoimmunology.

[75]  S. Nishio,et al.  The responses of macrophages in interaction with neutrophils that undergo NETosis. , 2016, Journal of autoimmunity.

[76]  H. Simon,et al.  Basophils exhibit antibacterial activity through extracellular trap formation , 2015, Allergy.

[77]  C. Bonorino,et al.  Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils , 2015, PloS one.

[78]  N. Palaniyar,et al.  SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx , 2015, Proceedings of the National Academy of Sciences.

[79]  M. E. El May,et al.  Autophagy mediates neutrophil responses to bacterial infection , 2014, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[80]  A. Zychlinsky,et al.  A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis , 2014, Cell reports.

[81]  H. Simon,et al.  NADPH Oxidase–Independent Formation of Extracellular DNA Traps by Basophils , 2014, The Journal of Immunology.

[82]  N. Palaniyar,et al.  Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis. , 2014, Blood.

[83]  P. Kubes,et al.  NETosis: how vital is it? , 2013, Blood.

[84]  Paul Kubes,et al.  Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. , 2013, The Journal of clinical investigation.

[85]  D. Wagner,et al.  Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice , 2013, Proceedings of the National Academy of Sciences.

[86]  A. Dvorak,et al.  PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans , 2013 .

[87]  J. Ben-Ezra,et al.  A proposed role for neutrophil extracellular traps in cancer immunoediting , 2013, Front. Immunol..

[88]  K. Tracey,et al.  HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[89]  S. Satchell,et al.  Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction. , 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[90]  M. Asaduzzaman,et al.  Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo , 2012, Nature Medicine.

[91]  A. Walch,et al.  Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo , 2012, The Journal of experimental medicine.

[92]  K. Preissner,et al.  Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones , 2012, PloS one.

[93]  H. Waldmann,et al.  Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. , 2011, Nature chemical biology.

[94]  M. Surette,et al.  A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus , 2010, The Journal of Immunology.

[95]  V. Nizet,et al.  Statins enhance formation of phagocyte extracellular traps. , 2010, Cell host & microbe.

[96]  Abdul Hakkim,et al.  Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps , 2010, The Journal of cell biology.

[97]  H. Simon,et al.  Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps , 2009, Cell Death and Differentiation.

[98]  G. Cheng,et al.  Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. , 2009, Cancer cell.

[99]  C. Allis,et al.  Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation , 2009, The Journal of cell biology.

[100]  M. Rohde,et al.  Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. , 2008, Blood.

[101]  Stephen R. Clark,et al.  Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood , 2007, Nature Medicine.

[102]  V. Wahn,et al.  Novel cell death program leads to neutrophil extracellular traps , 2007, The Journal of Cell Biology.

[103]  Steven Clarke,et al.  Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination , 2004, Science.

[104]  A. Zychlinsky,et al.  Neutrophil Extracellular Traps Kill Bacteria , 2004, Science.

[105]  S. Grinstein,et al.  The Tangled Webs That Neutrophils Weave , 2004, Science.

[106]  J. Dipersio,et al.  Human granulocyte colony-stimulating factor: biologic activities and receptor characterization on hematopoietic cells and small cell lung cancer cell lines. , 1990, Blood.

[107]  R. Clark,et al.  Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system , 1975, The Journal of experimental medicine.

[108]  E. León-Rodríguez,et al.  COULD NEUTROPHIL EXTRACELLULAR TRAPS BE THE NEW PROGNOSTIC MARKERS OF CANCER? , 2019, Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion.