KRONİK TOLUEN ENTOKSİKASYONUNA BAĞLI KORPUS KALLOZUM NEKROZU: PSİKİYATRİK BELİRTİLERLE SEYREDEN BİR OLGU SUNUMU Corpus Callosum Necrosis with Psychiatric Symptoms Resulting From Chronic Toluene Intoxication/Exposure: A Case Presentation

Norotoksik bir madde olan toluenin kotuye kullanimi norolojik ve psikiyatrik komplikasyonlara neden olmaktadir. Ancak, bazi is kollarinda calisan ve uzun sure toluen etkisinde kalan kisilerde de benzer etkiler olusabilmektedir. Goruntuleme calismalarinda, kronik toluen entoksikasyonu sonucu beyin hacminde kuculme ve yaygin madde degisiklikleri meydana geldigi bulunmustur. Beyinde olusan yapisal degisikliklere bagli olarak ilerleyici norolojik ve psikiyatrik belirtilerin ortaya ciktigi gosterilmistir. Bu yazida, isyerinde sekiz yil sureyle toluen etkisinde kalan, korpus kallozum nekrozu gelisen ve ilerleyici psikiyatrik belirtilerle seyreden bir olgu sunulmustur. Anahtar kelimeler: toluen entoksikasyonu, korpus kallozum, psikiyatrik belirtiler Abuse of toluene, which is a neurotoxic substance, causes neurological and psychiatric complications. Similar complications may also be seen in people who are exposed to toluene long term in some industries. Decrease of brain volume and generalised substance changes in brain have been found in imaging studies. Progressive neurological and psychiatric changes have been shown to be due to these changes. In this article, a subject was presented who was exposed to toluene at the workshop for 8 years and has suffered corpus callosum necrosis with progressive psychiatric symptoms.

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