The role of ubiquitylation in signaling by growth factors: implications to cancer.

[1]  Hai Rao,et al.  Recognition of Specific Ubiquitin Conjugates Is Important for the Proteolytic Functions of the Ubiquitin-associated Domain Proteins Dsk2 and Rad23* , 2002, The Journal of Biological Chemistry.

[2]  K. Wilhelmsen,et al.  C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus , 2002, Oncogene.

[3]  Y. Yarden,et al.  A mutant EGF‐receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling , 2002, The EMBO journal.

[4]  Bing Zhang,et al.  A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. , 2002, Genes & development.

[5]  H. Bellen,et al.  Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila , 2002, Cell.

[6]  Hanno Steen,et al.  Tyrosine Phosphorylation Mapping of the Epidermal Growth Factor Receptor Signaling Pathway* , 2002, The Journal of Biological Chemistry.

[7]  N. Moschonas,et al.  neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. , 2001, Developmental cell.

[8]  G M Rubin,et al.  Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. , 2001, Developmental cell.

[9]  H. Band,et al.  Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. , 2001, Molecular cell.

[10]  G. Schmalzing,et al.  Ubiquitination Precedes Internalization and Proteolytic Cleavage of Plasma Membrane-bound Glycine Receptors* , 2001, The Journal of Biological Chemistry.

[11]  F. Brodsky,et al.  Biological basket weaving: formation and function of clathrin-coated vesicles. , 2001, Annual review of cell and developmental biology.

[12]  T. Kohout,et al.  Regulation of Receptor Fate by Ubiquitination of Activated β2-Adrenergic Receptor and β-Arrestin , 2001, Science.

[13]  Colin Gordon,et al.  Proteins containing the UBA domain are able to bind to multi-ubiquitin chains , 2001, Nature Cell Biology.

[14]  A. Tsygankov,et al.  Beyond the RING: CBL proteins as multivalent adapters , 2001, Oncogene.

[15]  Li Chen,et al.  Ubiquitin‐associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi‐ubiquitin chain assembly , 2001, EMBO reports.

[16]  Fulvio Reggiori,et al.  Sorting of proteins into multivesicular bodies: ubiquitin‐dependent and ‐independent targeting , 2001, The EMBO journal.

[17]  H. Stenmark,et al.  Hrs recruits clathrin to early endosomes , 2001, The EMBO journal.

[18]  C. Pickart,et al.  Distinct Functional Surface Regions on Ubiquitin* , 2001, The Journal of Biological Chemistry.

[19]  S. Emr,et al.  Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I , 2001, Cell.

[20]  L. Hicke,et al.  Multiple Roles for Rsp5p-dependent Ubiquitination at the Internalization Step of Endocytosis* , 2001, The Journal of Biological Chemistry.

[21]  P. P. Di Fiore,et al.  Nucleocytoplasmic Shuttling of Endocytic Proteins , 2001, The Journal of cell biology.

[22]  H. Wiley,et al.  Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. , 2001, Molecular biology of the cell.

[23]  H. Jansen,et al.  c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. , 2001, Journal of cell science.

[24]  L. Falquet,et al.  A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. , 2001, Trends in biochemical sciences.

[25]  D. J. Clarke,et al.  UBA domains of DNA damage-inducible proteins interact with ubiquitin , 2001, Nature Structural Biology.

[26]  A. Dautry‐Varsat,et al.  Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments. , 2001, Molecular biology of the cell.

[27]  W. Langdon,et al.  Cbl: many adaptations to regulate protein tyrosine kinases , 2001, Nature Reviews Molecular Cell Biology.

[28]  M. Komada,et al.  Hrs and hbp: possible regulators of endocytosis and exocytosis. , 2001, Biochemical and biophysical research communications.

[29]  Xiaolong Wei,et al.  Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor* , 2001, The Journal of Biological Chemistry.

[30]  Linda Hicke,et al.  Ubiquitin and proteasomes: Protein regulation by monoubiquitin , 2001, Nature Reviews Molecular Cell Biology.

[31]  G. Guy,et al.  Evidence for Direct Interaction between Sprouty and Cbl* , 2001, The Journal of Biological Chemistry.

[32]  F. Walker,et al.  RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. , 2001, Molecular cell.

[33]  Y. Yarden,et al.  Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.

[34]  D. Bowtell,et al.  Cbl Associates with Pyk2 and Src to Regulate Src Kinase Activity, αvβ3 Integrin-Mediated Signaling, Cell Adhesion, and Osteoclast Motility , 2001, The Journal of cell biology.

[35]  K. Miyazawa,et al.  A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP* , 2000, The Journal of Biological Chemistry.

[36]  Y. Yarden,et al.  c-Cbl Is a Suppressor of the Neu Oncogene* , 2000, The Journal of Biological Chemistry.

[37]  Linyi Chen,et al.  Recycling of the Yeast a-Factor Receptor , 2000, The Journal of cell biology.

[38]  M. Crescenzi,et al.  Inhibition of ErbB-2 Mitogenic and Transforming Activity by RALT, a Mitogen-Induced Signal Transducer Which Binds to the ErbB-2 Kinase Domain , 2000, Molecular and Cellular Biology.

[39]  N. Kitamura,et al.  Endosomal Localization and Receptor Dynamics Determine Tyrosine Phosphorylation of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate , 2000, Molecular and Cellular Biology.

[40]  A. Ciechanover,et al.  The ubiquitin system , 2000, Nature Medicine.

[41]  T. Schüpbach,et al.  D-cbl, a Negative Regulator of the Egfr Pathway, Is Required for Dorsoventral Patterning in Drosophila Oogenesis , 2000, Cell.

[42]  N. Kitamura,et al.  Early Endosomal Localization of Hrs Requires a Sequence within the Proline- and Glutamine-rich Region but Not the FYVE Finger* , 2000, The Journal of Biological Chemistry.

[43]  S. Yamasaki,et al.  A Di-leucine Signal in the Ubiquitin Moiety , 2000, The Journal of Biological Chemistry.

[44]  C. Tacchetti,et al.  Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis , 2000, The Journal of cell biology.

[45]  P. Sternberg,et al.  ARK-1 inhibits EGFR signaling in C. elegans. , 2000, Molecular cell.

[46]  Y. Yarden,et al.  Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. , 2000, Cancer research.

[47]  S. Davanger,et al.  Hrs-2 Regulates Receptor-mediated Endocytosis via Interactions with Eps15* , 2000, The Journal of Biological Chemistry.

[48]  L. E. Johannessen,et al.  Polyubiquitination of the Epidermal Growth Factor Receptor Occurs at the Plasma Membrane upon Ligand-induced Activation* , 2000, The Journal of Biological Chemistry.

[49]  A L Cadavid,et al.  The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. , 2000, Development.

[50]  A. Parks,et al.  Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. , 2000, Development.

[51]  A. Roth,et al.  Ubiquitination of the PEST-like Endocytosis Signal of the Yeast a-Factor Receptor* , 2000, The Journal of Biological Chemistry.

[52]  H. Okano,et al.  The Interaction between the DrosophilaSecreted Protein Argos and the Epidermal Growth Factor Receptor Inhibits Dimerization of the Receptor and Binding of Secreted Spitz to the Receptor , 2000, Molecular and Cellular Biology.

[53]  S. Emr,et al.  Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal Trafficking , 2000, Traffic.

[54]  L. Hicke,et al.  Monoubiquitin carries a novel internalization signal that is appended to activated receptors , 2000, The EMBO journal.

[55]  N. Kitamura,et al.  A Hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors , 2000, Genes to cells : devoted to molecular & cellular mechanisms.

[56]  H. Stenmark,et al.  FYVE-finger proteins--effectors of an inositol lipid. , 1999, Journal of cell science.

[57]  A Ciechanover,et al.  Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. , 1999, Molecular cell.

[58]  G. Payne,et al.  Adaptor complex-independent clathrin function in yeast. , 1999, Molecular biology of the cell.

[59]  R. Baron,et al.  Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7* , 1999, The Journal of Biological Chemistry.

[60]  R. Baron,et al.  Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl , 1999, The Journal of Biological Chemistry.

[61]  T. Hunter,et al.  The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. , 1999, Science.

[62]  R. Scheller,et al.  The cellular and developmental expression of hrs‐2 in rat , 1999, The European journal of neuroscience.

[63]  Y. Yarden,et al.  The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.

[64]  D. Bowtell,et al.  The Cbl protooncoprotein stimulates CSF‐1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation , 1999, The EMBO journal.

[65]  R. Heilker,et al.  Recognition of sorting signals by clathrin adaptors , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[66]  H. Band,et al.  Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation , 1999, The Journal of Biological Chemistry.

[67]  M. Komada,et al.  Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. , 1999, Genes & development.

[68]  A. Sorkin,et al.  Inhibition of the receptor‐binding function of clathrin adaptor protein AP‐2 by dominant‐negative mutant μ2 subunit and its effects on endocytosis , 1999, The EMBO journal.

[69]  B. André,et al.  The yeast Npi1/Rsp5 ubiquitin ligase lacking its N-terminal C2 domain is competent for ubiquitination but not for subsequent endocytosis of the gap1 permease. , 1999, Biochemical and biophysical research communications.

[70]  N. Perrimon,et al.  The Transmembrane Molecule Kekkon 1 Acts in a Feedback Loop to Negatively Regulate the Activity of the Drosophila EGF Receptor during Oogenesis , 1999, Cell.

[71]  F. Brodsky,et al.  EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake , 1999, Cell.

[72]  Matthew Freeman,et al.  Sprouty, an Intracellular Inhibitor of Ras Signaling , 1999, Cell.

[73]  P. Pelicci,et al.  Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization. , 1999, Molecular biology of the cell.

[74]  B. J. Mayer,et al.  Endocytosis: EH domains lend a hand , 1999, Current Biology.

[75]  A. Schwartz,et al.  Identification of a novel ubiquitin conjugation motif, required for ligand‐induced internalization of the growth hormone receptor , 1999, The EMBO journal.

[76]  Z. Kam,et al.  c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. , 1998, Genes & development.

[77]  Gianni Cesareni,et al.  Recognition specificity of individual EH domains of mammals and yeast , 1998, The EMBO journal.

[78]  A. Roth,et al.  A Large PEST-like Sequence Directs the Ubiquitination, Endocytosis, and Vacuolar Degradation of the Yeast a-Factor Receptor , 1998, The Journal of cell biology.

[79]  S. Kellokumpu,et al.  EAST, an Epidermal Growth Factor Receptor- and Eps15-associated Protein with Src Homology 3 and Tyrosine-based Activation Motif Domains* , 1998, The Journal of Biological Chemistry.

[80]  A. Lenferink,et al.  Differential endocytic routing of homo‐ and hetero‐dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers , 1998, The EMBO journal.

[81]  B. Geiger,et al.  Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency* , 1998, The Journal of Biological Chemistry.

[82]  H. Riezman,et al.  Cytoplasmic Tail Phosphorylation of the α-Factor Receptor Is Required for Its Ubiquitination and Internalization , 1998, The Journal of cell biology.

[83]  Scott D. Emr,et al.  Pan1p, Yeast eps15, Functions as a Multivalent Adaptor That Coordinates Protein–Protein Interactions Essential for Endocytosis , 1998, The Journal of cell biology.

[84]  W. Langdon,et al.  Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells* , 1998, The Journal of Biological Chemistry.

[85]  S. Schmid,et al.  AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis , 1998, The Journal of cell biology.

[86]  M. Glickman,et al.  Multiubiquitin Chain Binding and Protein Degradation Are Mediated by Distinct Domains within the 26 S Proteasome Subunit Mcb1* , 1998, The Journal of Biological Chemistry.

[87]  N. Tanaka,et al.  Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule , 1997, The Journal of Biological Chemistry.

[88]  P. Pelicci,et al.  eps15 and eps15R are essential components of the endocytic pathway. , 1997, Cancer research.

[89]  O. Staub,et al.  Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination , 1997, The EMBO journal.

[90]  S. K. Kim,et al.  Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. , 1997, Genes & development.

[91]  G Cesareni,et al.  Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. , 1997, Genes & development.

[92]  A. Sorkin,et al.  Eps15 Is Constitutively Oligomerized Due to Homophilic Interaction of Its Coiled-coil Region* , 1997, The Journal of Biological Chemistry.

[93]  A. Verkleij,et al.  Epidermal Growth Factor Induces Ubiquitination of Eps15* , 1997, The Journal of Biological Chemistry.

[94]  W. Langdon,et al.  EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene , 1997, Oncogene.

[95]  N. Perrimon,et al.  There Must Be 50 Ways to Rule the Signal: The Case of the Drosophila EGF Receptor , 1997, Cell.

[96]  N. Hynes,et al.  ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling , 1997, The EMBO journal.

[97]  U. Banerjee,et al.  Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development , 1997, Molecular and cellular biology.

[98]  R. A. Warren,et al.  Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor* , 1997, The Journal of Biological Chemistry.

[99]  G. Payne,et al.  The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae , 1996, The Journal of cell biology.

[100]  Sakae Tanaka,et al.  c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption , 1996, Nature.

[101]  Y. Yarden,et al.  A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor , 1996, Molecular and cellular biology.

[102]  A. Dautry‐Varsat,et al.  The Ear of -Adaptin Interacts with the COOH-terminal Domain of the Eps15 Protein (*) , 1996, The Journal of Biological Chemistry.

[103]  P. Bucher,et al.  The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. , 1996, Trends in biochemical sciences.

[104]  Howard Riezman,et al.  Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis , 1996, Cell.

[105]  W. Langdon,et al.  c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages (*) , 1996, The Journal of Biological Chemistry.

[106]  M. Komada,et al.  Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain , 1995, Molecular and cellular biology.

[107]  T. Stevens,et al.  VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae , 1995, The Journal of cell biology.

[108]  H. Wiley,et al.  Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[109]  P. Sternberg,et al.  Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl , 1995, Science.

[110]  P. Sternberg,et al.  sli-1, a negative regulator of let-23-mediated signaling in C. elegans. , 1995, Genetics.

[111]  S. Schmid,et al.  Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase , 1995, The Journal of cell biology.

[112]  C. Marshall,et al.  Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.

[113]  L. Cantley,et al.  Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[114]  Q. Deveraux,et al.  A 26 S protease subunit that binds ubiquitin conjugates. , 1994, The Journal of biological chemistry.

[115]  J. Rohrer,et al.  Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast. , 1993, Molecular biology of the cell.

[116]  L. Minichiello,et al.  Identification and biochemical characterization of novel putative substrates for the epidermal growth factor receptor kinase. , 1992, The Journal of biological chemistry.

[117]  J. Welsh,et al.  Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. , 1990, Science.

[118]  A. Basu,et al.  Inhibition of tyrosine kinase activity of the epidermal growth factor (EGF) receptor by a truncated receptor form that binds to EGF: role for interreceptor interaction in kinase regulation. , 1989, Molecular and cellular biology.

[119]  S. Klinken,et al.  v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[120]  Y. Yarden,et al.  Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. , 1987, Biochemistry.

[121]  Joseph L. Goldstein,et al.  Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain , 1985, Cell.

[122]  A. Ullrich,et al.  Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences , 1984, Nature.

[123]  E. Stanley,et al.  CSF‐1 stimulated multiubiquitination of the CSF‐1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins , 1999, Journal of cellular biochemistry.