Comprehensive profiling of mercapturic acid metabolites from dietary acrylamide as short-term exposure biomarkers for evaluation of toxicokinetics in rats and daily internal exposure in humans using isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry.

[1]  Seok Won Jeong,et al.  Determination of acrylamide and glycidamide in various biological matrices by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study. , 2015, Talanta.

[2]  Y. Liu,et al.  Risk assessment, formation, and mitigation of dietary acrylamide: current status and future prospects. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[3]  Fa-Ju Chen,et al.  Simultaneous analysis of acrylamide and its key precursors, intermediates, and products in model systems by liquid chromatography-triple quadrupole mass spectrometry. , 2013, Analytical chemistry.

[4]  M. Warholm,et al.  Hemoglobin adducts as a measure of variations in exposure to acrylamide in food and comparison to questionnaire data. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  D. Lineback,et al.  Acrylamide in foods: a review of the science and future considerations. , 2012, Annual review of food science and technology.

[6]  J. Angerer,et al.  Determination of 2,3-dihydroxypropionamide, an oxidative metabolite of acrylamide, in human urine by gas chromatography coupled with mass spectrometry , 2012, Analytical and Bioanalytical Chemistry.

[7]  Yiping Ren,et al.  Ultra high-performance liquid chromatography-tandem mass spectrometry for the simultaneous analysis of asparagine, sugars, and acrylamide in Maillard reactions. , 2011, Analytical chemistry.

[8]  J. Angerer,et al.  Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide , 2011, Archives of Toxicology.

[9]  Ian A Blair,et al.  Stable-isotope dilution LC–MS for quantitative biomarker analysis. , 2010, Bioanalysis.

[10]  A. Kord,et al.  Theoretical and experimental comparison of mobile phase consumption between ultra-high-performance liquid chromatography and high performance liquid chromatography. , 2009, Journal of chromatography. A.

[11]  B. Blount,et al.  Simultaneous determination of six mercapturic acid metabolites of volatile organic compounds in human urine. , 2009, Chemical research in toxicology.

[12]  W. Dekant,et al.  Toxicokinetics of acrylamide in rats and humans following single oral administration of low doses. , 2009, Toxicology and applied pharmacology.

[13]  U. Fuhr,et al.  In vivo Role of Cytochrome P450 2E1 and Glutathione-S-Transferase Activity for Acrylamide Toxicokinetics in Humans , 2009, Cancer Epidemiology Biomarkers & Prevention.

[14]  J. Angerer,et al.  N-Acetyl-S-(1-carbamoyl-2-hydroxy-ethyl)-l-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: comparison with the simultaneously excreted other mercaptuic acids , 2009, Archives of Toxicology.

[15]  W. Dekant,et al.  Rapid and sensitive HILIC-ESI-MS/MS quantitation of polar metabolites of acrylamide in human urine using column switching with an online trap column. , 2008, Journal of agricultural and food chemistry.

[16]  T. Schettgen,et al.  Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acrolein (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography/tandem mass spectrometry. , 2008, Rapid communications in mass spectrometry : RCM.

[17]  U. Neue,et al.  Selectivity in reversed-phase separations: general influence of solvent type and mobile phase pH. , 2007, Journal of separation science.

[18]  J. Exon.  A Review of the Toxicology of Acrylamide , 2006, Journal of toxicology and environmental health. Part B, Critical reviews.

[19]  S. Wagner,et al.  Quantitation of mercapturic acids from acrylamide and glycidamide in human urine using a column switching tool with two trap columns and electrospray tandem mass spectrometry. , 2006, Journal of chromatography. A.

[20]  T. Fennell,et al.  Kinetics of elimination of urinary metabolites of acrylamide in humans. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[21]  U. Fuhr,et al.  Toxicokinetics of Acrylamide in Humans after Ingestion of a Defined Dose in a Test Meal to Improve Risk Assessment for Acrylamide Carcinogenicity , 2006, Cancer Epidemiology Biomarkers & Prevention.

[22]  G. Scherer,et al.  Urinary Mercapturic Acids and a Hemoglobin Adduct for the Dosimetry of Acrylamide Exposure in Smokers and Nonsmokers , 2006, Inhalation toxicology.

[23]  J. Angerer,et al.  Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide , 2006, Archives of Toxicology.

[24]  John F. Young,et al.  Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats. , 2005, Toxicology and applied pharmacology.

[25]  T. Fennell,et al.  Metabolism and hemoglobin adduct formation of acrylamide in humans. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[26]  J. Angerer,et al.  Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population. , 2005, Mutation research.

[27]  John F. Young,et al.  Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice. , 2005, Toxicology and applied pharmacology.

[28]  Marc De Loose,et al.  Trends in quality in the analytical laboratory. II. Analytical method validation and quality assurance , 2004 .

[29]  M. Churchwell,et al.  DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice. , 2003, Chemical research in toxicology.

[30]  B. Wedzicha,et al.  Food chemistry: Acrylamide is formed in the Maillard reaction , 2002, Nature.

[31]  Imre Blank,et al.  Food chemistry: Acrylamide from Maillard reaction products , 2002, Nature.

[32]  L. Perbellini,et al.  Analysis of urinary N-acetyl-S-(N-methylcarbamoyl)cysteine, the mercapturic acid derived from N,N-dimethylformamide. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[33]  W. Dekant,et al.  Gas chromatography-negative ion chemical ionization mass spectrometry as a powerful tool for the detection of mercapturic acids and DNA and protein adducts as biomarkers of exposure to halogenated olefins. , 1999, Journal of chromatography. A.

[34]  P. Jandera.  Simultaneous optimisation of gradient time, gradient shape and initial composition of the mobile phase in the high-performance liquid chromatography of homologous and oligomeric series , 1999 .

[35]  M. Imbriani,et al.  Determination of urinary mercapturic acids of styrene in man by high-performance liquid chromatography with fluorescence detection. , 1996, Journal of chromatography. B, Biomedical applications.

[36]  D. Brusick,et al.  Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. , 1995, Mutation research.

[37]  N. Loprieno.  International Agency for Research on Cancer (IARC) monographs on the evaluation of carcinogenic risk of chemicals to man: “Relevance of data on mutagenicity” , 1975 .