Sex differences in DNA damage produced by the carcinogen 2-acetylaminofluorene in cultured human hepatocytes compared to rat liver and cultured rat hepatocytes

[1]  M. Iatropoulos,et al.  A no observed adverse effect level for DNA adduct formation in rat liver with prolonged dosing of the hepatocarcinogen 2-acetylaminofluorene , 2015 .

[2]  Gary M Williams,et al.  LACK OF DNA BINDING IN THE RAT NASAL MUCOSA AND OTHER TISSUES OF THE NASAL TOXICANTS ROFLUMILAST, A PHOSPHODIESTERASE 4 INHIBITOR, AND A METABOLITE, 4-AMINO-3,5-DICHLOROPYRIDINE, IN CONTRAST TO THE NASAL CARCINOGEN 2,6-DIMETHYLANILINE* , 2002, Drug and chemical toxicology.

[3]  R. Gebhardt,et al.  Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver. , 1998, Toxicological sciences : an official journal of the Society of Toxicology.

[4]  G. Williams,et al.  Effect of rodent hepatocarcinogenic peroxisome proliferators on fatty acyl-CoA oxidase, DNA synthesis, and apoptosis in cultured human and rat hepatocytes. , 1998, Toxicology and applied pharmacology.

[5]  R. Gebhardt,et al.  Inhibition by gonadectomy of effects of 2-acetylaminofluorene in livers of male, but not female rats. , 1993, Carcinogenesis.

[6]  S. J. Culp,et al.  Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene. , 1993, Environmental health perspectives.

[7]  R. Gupta,et al.  Carcinogen-DNA adducts in cultures of rat and human hepatocytes. , 1992, Cancer letters.

[8]  G. Williams,et al.  Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals. , 1989, Mutation research.

[9]  Ramesh C. Gupta.  32P-adduct assay: Short- and long-term persistence of 2-acetylaminofluorene-DNA adducts and other applications of the assay , 1988, Cell Biology and Toxicology.

[10]  G. Williams,et al.  Genotoxicity of carcinogens in human hepatocytes: application in hazard assessment. , 1988, Toxicology and applied pharmacology.

[11]  Gary M Williams,et al.  Sex differences in the biotransformation of 2-acetylaminofluorene in cultured rat hepatocytes , 1986, Cell Biology and Toxicology.

[12]  B. Trump,et al.  Isolation and culture of hepatocytes from human liver of immediate autopsy , 1985, In Vitro Cellular & Developmental Biology.

[13]  G. Williams,et al.  Early stages of N-2-fluorenylacetamide-induced hepatocarcinogenesis in male and female rats and effect of gonadectomy on liver neoplastic conversion and neoplastic development. , 1984, Journal of the National Cancer Institute.

[14]  G. Michalopoulos,et al.  Genotoxic effects of 2-acetylaminofluorene on rat and human hepatocytes. , 1983, Environmental health perspectives.

[15]  F. Beland,et al.  Persistence of DNA adducts in rat liver and kidney after multiple doses of the carcinogen N-hydroxy-2-acetylaminofluorene. , 1982, Cancer research.

[16]  J A Miller,et al.  DNA repair in primary cultures of rat hepatocytes. , 1978, Cancer research.

[17]  G. Williams,et al.  Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures. , 1977, Cancer research.

[18]  C. King.  Mechanism of reaction, tissue distribution, and inhibition of arylhydroxamic acid acyltransferase. , 1974, Cancer research.

[19]  J. Miller,et al.  Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver. , 1972, Biochimica et biophysica acta.

[20]  J. Miller,et al.  N-hydroxy-2-acetylaminofluorene sulfotransferase: its probable role in carcinogenesis and in protein-(methion-S-yl) binding in rat liver. , 1970, Cancer research.

[21]  G. Williams.  Chemicals with Carcinogenic Activity in Rodent Liver , 2010 .

[22]  G. Williams,et al.  2-Acetylaminofluorene mechanistic data and risk assessment: DNA reactivity, enhanced cell proliferation and tumor initiation. , 1996, Pharmacology & therapeutics.