Longitudinal association of serum carotenoids and tocopherols with hostility: the CARDIA Study.

Hostility is a personality trait associated with increased risk of coronary heart disease. No study has reported the association between hostility and antioxidants, which may be mediators for atherosclerosis. CARDIA (Coronary Artery Risk Development in Young Adults) Study participants were 3,579 men and women 18-30 years of age in 1985-1986. Serum carotenoids and tocopherols were measured at years 0 and 7, and hostility was measured at years 0 and 5. Analysis of covariance was used to test for covariate-adjusted differences in serum carotenoids and tocopherols across quartiles of hostility. After adjustment for age, gender, race, serum lipids, and baseline of the dependent variable, the mean carotenoid values at year 7 of the lowest and highest quartiles of hostility score at year 0 were 3.9 and 3.3 microg/liter for alpha-carotene (p < 0.001), 9.1 and 8.0 microg/liter for beta-cryptoxanthin (p < 0.001), and 50.6 and 46.8 microg/liter for the sum of four carotenoids (p < 0.001). Hostility scores at year 0 were unrelated to year 7 lycopene and tocopherols. In contrast, neither year 0 carotenoids nor tocopherols predicted the hostility score at year 5. High hostility predicted future low levels of some serum carotenoids, which may help to explain the association of hostility and cardiovascular risk observed in other epidemiologic studies.

[1]  J. Dwyer,et al.  Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[2]  J L Witztum,et al.  Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. , 1989, The New England journal of medicine.

[3]  D. Jacobs,et al.  Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: interaction with smoking: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. , 2006, American journal of epidemiology.

[4]  F. Kobayashi,et al.  Possible connections among job stress, depressive symptoms, lipid modulation and antioxidants. , 2006, Journal of affective disorders.

[5]  S. Knox,et al.  Hostility and physiological risk in the National Heart, Lung, and Blood Institute Family Heart Study. , 2004, Archives of internal medicine.

[6]  D. Jacobs,et al.  Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. , 2007, Clinical chemistry.

[7]  S. Schanberg,et al.  Neuroendocrine, Cardiovascular, and Emotional Responses of Hostile Men: The Role of Interpersonal Challenge , 1998, Psychosomatic medicine.

[8]  M. Chesney,et al.  Cook‐Medley Hostility scale and subsets: relationship to demographic and psychosocial characteristics in young adults in the CARDIA study. , 1991, Psychosomatic medicine.

[9]  S B Hulley,et al.  CARDIA: study design, recruitment, and some characteristics of the examined subjects. , 1988, Journal of clinical epidemiology.

[10]  A. Folsom,et al.  Hemostatic factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[11]  E. Rimm,et al.  Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. , 2004, The American journal of clinical nutrition.

[12]  Kiang Liu,et al.  Psychosocial factors and risk of hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. , 2004, JAMA.

[13]  S. Watanabe,et al.  Relationship of serum cholesterols and vitamin E to depressive status in the elderly. , 1999, Journal of epidemiology.

[14]  J. Salonen,et al.  Hostility and increased risk of mortality and acute myocardial infarction: the mediating role of behavioral risk factors. , 1997, American journal of epidemiology.

[15]  L. Appel,et al.  Relationship between systemic markers of inflammation and serum beta-carotene levels. , 2001, Archives of internal medicine.

[16]  J. C. Smith,et al.  Effects of storage and handling conditions on concentrations of individual carotenoids, retinol, and tocopherol in plasma. , 1988, Clinical chemistry.

[17]  J. Manson,et al.  Dietary carotenoids and risk of coronary artery disease in women. , 2003, The American journal of clinical nutrition.

[18]  D. Jacobs,et al.  Lipid standardization of serum fat-soluble antioxidant concentrations: the YALTA study. , 2003, The American journal of clinical nutrition.

[19]  W. Willett,et al.  Prospective Study of Plasma Carotenoids and Tocopherols in Relation to Risk of Ischemic Stroke , 2004, Stroke.

[20]  D. Jacobs,et al.  Validity and Reliability of Short Physical Activity History: Cardia and the Minnesota Heart Health Program. , 1989, Journal of cardiopulmonary rehabilitation.

[21]  C. Lewis,et al.  Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. , 2003, Clinical chemistry.

[22]  D. Jacobs,et al.  Dietary intake of n-3, n-6 fatty acids and fish: Relationship with hostility in young adults—the CARDIA study , 2004, European Journal of Clinical Nutrition.

[23]  R. Niaura,et al.  Hostility and the Metabolic Syndrome in Older Males: The Normative Aging Study , 2000, Psychosomatic medicine.

[24]  Pamela J Schreiner,et al.  Longitudinal associations between body mass index and serum carotenoids: the CARDIA study , 2006, British Journal of Nutrition.

[25]  D. Jacobs,et al.  Association between serum gamma-glutamyltransferase and C-reactive protein. , 2005, Atherosclerosis.

[26]  T. W. Smith,et al.  What's so unhealthy about hostility? Construct validity and psychosocial correlates of the Cook and Medley Ho scale. , 1985, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[27]  Walter W. Cook,et al.  Proposed hostility and Pharisaic-virtue scales for the MMPI. , 1954 .

[28]  P. Ridker,et al.  Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. , 2006, JAMA.

[29]  D. Jacobs,et al.  Stability of carotenoids and alpha-tocopherol during blood collection and processing procedures. , 1995, Clinical chemistry.

[30]  E. Coccaro Association of C-reactive protein elevation with trait aggression and hostility in personality disordered subjects: a pilot study. , 2006, Journal of psychiatric research.

[31]  G Cutter,et al.  A study of the reliability and comparative validity of the cardia dietary history. , 1994, Ethnicity & disease.

[32]  C. Lewis,et al.  γ-Glutamyltransferase Is a Predictor of Incident Diabetes and Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study , 2003 .

[33]  F. Treiber,et al.  Hostility: relationship to lifestyle behaviors and physical risk factors. , 1992, Behavioral medicine.

[34]  T. Manolio,et al.  Hostility and health behaviors in young adults: the CARDIA Study. Coronary Artery Risk Development in Young Adults Study. , 1992, American journal of epidemiology.

[35]  K. Matthews,et al.  Effects of Hostility on Platelet Reactivity to Psychological Stress in Coronary Heart Disease Patients and in Healthy Controls , 1996, Psychosomatic medicine.

[36]  H. Kasai,et al.  Relationships between perceived workload, stress and oxidative DNA damage , 2001, International archives of occupational and environmental health.

[37]  C. Gluud,et al.  Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis , 2004, The Lancet.

[38]  J. C. Smith,et al.  Determination of Individual Carotenoids in Human Plasma by High Performance Liquid Chromatography , 1985 .

[39]  A. Folsom,et al.  Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis. A case-control study. The ARIC Study Investigators. Atherosclerosis Risk in Communities. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[40]  M. Pahor,et al.  Serum carotenoids and markers of inflammation in nonsmokers. , 2000, American journal of epidemiology.