Structure-function analysis of TRPV channels

In recent years many new members of the family of TRP ion channels have been identified. These channels are classified into several subgroups and participate in many sensory and physiological functions. TRPV channels are important for the perception of pain, temperature sensing, osmotic regulation, and maintenance of calcium homeostasis, and much recent research concerns the identification of protein domains involved in mediating specific channel functions. Recent literature on TRPV channel subunit composition, protein domains required for subunit assembly, trafficking, and regulation will be reviewed and discussed.

[1]  P. McNaughton,et al.  Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor , 2003, The Journal of physiology.

[2]  V. Flockerzi,et al.  Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives* , 2002, The Journal of Biological Chemistry.

[3]  H. Schaller,et al.  The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC. , 2001, Journal of cell science.

[4]  S. Smerdon,et al.  The ankyrin repeat: a diversity of interactions on a common structural framework. , 1999, Trends in biochemical sciences.

[5]  K. Groschner,et al.  Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells. , 1999, Cardiovascular research.

[6]  T. Kumazawa,et al.  Evidence that protein kinase C activation is involved in the excitatory and facilitatory effects of bradykinin on canine visceral nociceptors in vitro , 1997, Neuroscience Letters.

[7]  S. V. D. van de Graaf,et al.  Molecular Determinants in TRPV5 Channel Assembly* , 2004, Journal of Biological Chemistry.

[8]  D. J. Brasier,et al.  cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation , 2002, Neuron.

[9]  Zhefeng Gong,et al.  Two Interdependent TRPV Channel Subunits, Inactive and Nanchung, Mediate Hearing in Drosophila , 2004, The Journal of Neuroscience.

[10]  W. Willis,et al.  The effect of phorbol esters on spinal cord amino acid concentrations and responsiveness of rats to mechanical and thermal stimuli , 1999, Pain.

[11]  O. Platt,et al.  A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin. , 1993, The Journal of biological chemistry.

[12]  S. Simon,et al.  TRPV1b, a Functional Human Vanilloid Receptor Splice Variant , 2005, Molecular Pharmacology.

[13]  B. Nilius,et al.  Invertebrate TRP proteins as functional models for mammalian channels , 2004, Pflügers Archiv.

[14]  John D. Scott,et al.  AKAP signalling complexes: focal points in space and time , 2004, Nature Reviews Molecular Cell Biology.

[15]  D. Clapham,et al.  TRPC5 is a regulator of hippocampal neurite length and growth cone morphology , 2003, Nature Neuroscience.

[16]  A. Gordon-Shaag,et al.  Ca 2 / Calmodulin Modulates TRPV 1 Activation by Capsaicin , 2003 .

[17]  G. Salido,et al.  A role for SNAP‐25 but not VAMPs in store‐mediated Ca2+ entry in human platelets , 2004, The Journal of physiology.

[18]  A. Moriondo,et al.  Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide , 2001, The Journal of physiology.

[19]  M. Chao,et al.  Annexin II light chain regulates sensory neuron-specific sodium channel expression , 2002, Nature.

[20]  S. Grinstein,et al.  Activation of Store-operated Calcium Channels , 2003, Journal of Biological Chemistry.

[21]  S. Ambudkar,et al.  VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx. , 2004, Molecular cell.

[22]  T. Gudermann,et al.  Subunit composition of mammalian transient receptor potential channels in living cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[23]  G. Rubin,et al.  Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction , 1989, Neuron.

[24]  G. Schultz,et al.  Ca2+-dependent Potentiation of the Nonselective Cation Channel TRPV4 Is Mediated by a C-terminal Calmodulin Binding Site* , 2003, Journal of Biological Chemistry.

[25]  T. Gudermann,et al.  Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels , 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

[26]  Yun Wang,et al.  Interaction between protein kinase Cmu and the vanilloid receptor type 1. , 2004, The Journal of biological chemistry.

[27]  Peter M. Blumberg,et al.  Analysis of the Native Quaternary Structure of Vanilloid Receptor 1* 210 , 2001, The Journal of Biological Chemistry.

[28]  Yufang Tang,et al.  Association of Mammalian Trp4 and Phospholipase C Isozymes with a PDZ Domain-containing Protein, NHERF* , 2000, The Journal of Biological Chemistry.

[29]  P. Budde,et al.  Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1β , 2002, FEBS letters.

[30]  K. Krause,et al.  The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. , 2002, Journal of cell science.

[31]  G. Fernández-Ballester,et al.  Identification of a Tetramerization Domain in the C Terminus of the Vanilloid Receptor , 2004, The Journal of Neuroscience.

[32]  L. Kelly,et al.  Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene , 1992, Neuron.

[33]  U. Wissenbach,et al.  Molecular Determinants of Permeation through the Cation Channel TRPV4* , 2002, The Journal of Biological Chemistry.

[34]  R. Tsien,et al.  Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger , 1999, Cell.

[35]  W. Schilling,et al.  Selective Association of TRPC Channel Subunits in Rat Brain Synaptosomes* 210 , 2002, The Journal of Biological Chemistry.

[36]  T. Sugimoto,et al.  Ca2+/calmodulin-dependent protein kinase II in the rat cranial sensory ganglia , 2004, Brain Research.

[37]  S. Hwang,et al.  Phosphorylation of Vanilloid Receptor 1 by Ca2+/Calmodulin-dependent Kinase II Regulates Its Vanilloid Binding* , 2004, Journal of Biological Chemistry.

[38]  R. Hardie,et al.  The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors , 1992, Neuron.

[39]  Emiko Suzuki,et al.  A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade , 1997, Nature.

[40]  Y. Kuryshev,et al.  KChAP as a chaperone for specific K(+) channels. , 2000, American journal of physiology. Cell physiology.

[41]  L. Salkoff,et al.  TRPγ, a Drosophila TRP–Related Subunit, Forms a Regulated Cation Channel with TRPL , 2000, Neuron.

[42]  B. Schwappach,et al.  14-3-3 Dimers Probe the Assembly Status of Multimeric Membrane Proteins , 2003, Current Biology.

[43]  M. Zhu,et al.  An Alternative Splicing Product of the Murine trpv1 Gene Dominant Negatively Modulates the Activity of TRPV1 Channels* , 2004, Journal of Biological Chemistry.

[44]  E. Aandahl,et al.  Localized effects of cAMP mediated by distinct routes of protein kinase A. , 2004, Physiological reviews.

[45]  D. Clapham,et al.  Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Brain* , 2003, Journal of Biological Chemistry.

[46]  Alexander J Stokes,et al.  A TRPV2–PKA Signaling Module for Transduction of Physical Stimuli in Mast Cells , 2004, The Journal of experimental medicine.

[47]  Z. Peng,et al.  Consensus-derived structural determinants of the ankyrin repeat motif , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[48]  T. Bisogno,et al.  The vanilloid receptor (VR1)‐mediated effects of anandamide are potently enhanced by the cAMP‐dependent protein kinase , 2001, Journal of neurochemistry.

[49]  Heidi L. Rehm,et al.  TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells , 2004, Nature.

[50]  G. Schultz,et al.  FRET-based analysis of TRPC subunit stoichiometry. , 2003, Cell calcium.

[51]  M. Lazdunski,et al.  p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK‐1 , 2002, The EMBO journal.

[52]  B. Kaang,et al.  The cAMP-dependent kinase pathway does not sensitize the cloned vanilloid receptor type 1 expressed in Xenopus oocytes or Aplysia neurons , 2000, Neuroscience Letters.

[53]  M. Tominaga,et al.  Direct Phosphorylation of Capsaicin Receptor VR1 by Protein Kinase Cε and Identification of Two Target Serine Residues* , 2002, The Journal of Biological Chemistry.

[54]  L. Bourguignon,et al.  The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells. , 1993, The Journal of biological chemistry.

[55]  B. Nilius,et al.  Mg2+-dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6 , 2003, The Journal of general physiology.

[56]  V. Bennett,et al.  The ANK Repeats of Erythrocyte Ankyrin Form Two Distinct but Cooperative Binding Sites for the Erythrocyte Anion Exchanger (*) , 1995, The Journal of Biological Chemistry.

[57]  M. Tsai,et al.  Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship. , 2004, Biochemistry.

[58]  Shobha Ghosh,et al.  The mammalian amiloride‐insensitive non‐specific salt taste receptor is a vanilloid receptor‐1 variant , 2004, The Journal of physiology.

[59]  B. Nilius,et al.  Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10–annexin 2 complex , 2003, The EMBO journal.

[60]  H. Kahr,et al.  CaT1 knock‐down strategies fail to affect CRAC channels in mucosal‐type mast cells , 2004, The Journal of physiology.

[61]  V. Flockerzi,et al.  Ca2+-selective Transient Receptor Potential V Channel Architecture and Function Require a Specific Ankyrin Repeat* , 2004, Journal of Biological Chemistry.

[62]  H. Watanabe,et al.  Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[63]  L. Breeden,et al.  Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila , 1987, Nature.

[64]  V. Flockerzi,et al.  Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[65]  M. Schaefer,et al.  Receptor-operated cation channels formed by TRPC4 and TRPC5 , 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

[66]  D. Clapham,et al.  TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain , 2001, Neuron.

[67]  M. Tominaga,et al.  Regulation mechanisms of vanilloid receptors. , 2004, Novartis Foundation symposium.

[68]  F. Hucho,et al.  Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line. , 2001, European journal of biochemistry.

[69]  C. Zuker,et al.  The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL , 1996, Cell.

[70]  D. J. Brasier,et al.  Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[71]  C. Montell.  Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels , 2001, Science's STKE.

[72]  Samuel E. Lux,et al.  Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins , 1990, Nature.

[73]  R. Kass,et al.  KChAP: a novel chaperone for specific K(+) channels key to repolarization of the cardiac action potential. Focus on "KChAP as a chaperone for specific K(+) channels". , 2000, American journal of physiology. Cell physiology.

[74]  R. O'neil,et al.  Temperature-modulated Diversity of TRPV4 Channel Gating , 2003, Journal of Biological Chemistry.

[75]  M. Kazanietz,et al.  Divergence and complexities in DAG signaling: looking beyond PKC. , 2003, Trends in pharmacological sciences.

[76]  M. Kanzaki,et al.  Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I , 1999, Nature Cell Biology.

[77]  A. Gordon-Shaag,et al.  Ca2+/Calmodulin Modulates TRPV1 Activation by Capsaicin , 2004, The Journal of general physiology.

[78]  R. Vennekens,et al.  The Single Pore Residue Asp542 Determines Ca2+ Permeation and Mg2+ Block of the Epithelial Ca2+ Channel* , 2001, The Journal of Biological Chemistry.

[79]  M. Schumacher,et al.  The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. , 2001, Genomics.

[80]  Jonathon Howard,et al.  Hypothesis: A helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors , 2004, Current Biology.

[81]  Cori Bargmann,et al.  Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons , 2002, Neuron.

[82]  A. Basbaum,et al.  Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition , 2001, Nature.

[83]  L. Kelly,et al.  Identification and characterization of two distinct calmodulin-binding sites in the Trpl ion-channel protein of Drosophila melanogaster. , 1996, The Biochemical journal.

[84]  B. Shieh,et al.  Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors , 1996, Neuron.

[85]  Vassilios J. Bezzerides,et al.  Rapid vesicular translocation and insertion of TRP channels , 2004, Nature Cell Biology.

[86]  C. Montell,et al.  Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance , 1997, Cell.

[87]  A. Ferrer-Montiel,et al.  Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties* , 2000, The Journal of Biological Chemistry.

[88]  Kiyotsugu Yoshida,et al.  Regulation of a Transient Receptor Potential (TRP) Channel by Tyrosine Phosphorylation , 2003, The Journal of Biological Chemistry.

[89]  A. Weidema,et al.  Regulation of the Mouse Epithelial Ca2+ Channel TRPV6 by the Ca2+-sensor Calmodulin* , 2004, Journal of Biological Chemistry.

[90]  N. Hoffman,et al.  Functional Analysis of the Protein-interacting Domains of Chloroplast SRP43* , 2001, The Journal of Biological Chemistry.

[91]  Daniel C. Desrosiers,et al.  The ankyrin repeat as molecular architecture for protein recognition , 2004, Protein science : a publication of the Protein Society.

[92]  Alexander J Stokes,et al.  RGA protein associates with a TRPV ion channel during biosynthesis and trafficking , 2004, Journal of cellular biochemistry.

[93]  A. Ferrer-Montiel,et al.  Regulated Exocytosis Contributes to Protein Kinase C Potentiation of Vanilloid Receptor Activity* , 2004, Journal of Biological Chemistry.

[94]  David E. Clapham,et al.  TRP channels as cellular sensors , 2003, Nature.

[95]  V. Flockerzi,et al.  Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster , 1997, FEBS letters.

[96]  V. Flockerzi,et al.  Expression of CaT-like, a Novel Calcium-selective Channel, Correlates with the Malignancy of Prostate Cancer* , 2001, The Journal of Biological Chemistry.

[97]  A. Nicke,et al.  Monomeric and dimeric byproducts are the principal functional elements of higher order P2X1 concatamers. , 2003, Molecular pharmacology.

[98]  M. Schumacher,et al.  Molecular Cloning of an N-terminal Splice Variant of the Capsaicin Receptor , 2000, The Journal of Biological Chemistry.

[99]  B. Nilius,et al.  Homo‐ and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6 , 2003, The EMBO journal.

[100]  C. Montell.  New light on TRP and TRPL. , 1997, Molecular pharmacology.

[101]  S. Weremowicz,et al.  Human calcium transport protein CaT1. , 2000, Biochemical and biophysical research communications.

[102]  L. Birnbaumer,et al.  The Membrane Topology of Human Transient Receptor Potential 3 as Inferred from Glycosylation-scanning Mutagenesis and Epitope Immunocytochemistry* , 1998, The Journal of Biological Chemistry.

[103]  Raphael Kopan,et al.  Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. , 2004, Molecular cell.

[104]  K. Groschner,et al.  TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals , 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

[105]  L. Premkumar,et al.  Induction of vanilloid receptor channel activity by protein kinase C , 2000, Nature.

[106]  C. Zuker,et al.  Calmodulin Regulation of Drosophila Light-Activated Channels and Receptor Function Mediates Termination of the Light Response In Vivo , 1997, Cell.

[107]  F. Zufall.  The TRPC2 ion channel and pheromone sensing in the accessory olfactory system , 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

[108]  M. Tominaga,et al.  Structural determinant of TRPV1 desensitization interacts with calmodulin , 2003, Proceedings of the National Academy of Sciences of the United States of America.