Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood

An optical approach allowing the extraction and the separation of remote vibration sources has recently been proposed. The approach has also been applied for medical related applications as blood pressure and heart beats monitoring. In this paper we demonstrate its capability to monitor glucose concentration in blood stream. The technique is based on the tracking of temporal changes of reflected secondary speckle produced in human skin (wrist) when being illuminated by a laser beam. A temporal change in skin’s vibration profile generated due to blood pulsation is analyzed for estimating the glucose concentration. Experimental tests that were carried out in order to verify the proposed approach showed good match with the change of the glucose level at the positive slope stage as it was obtained from conventional reference measurement.

[1]  Inga Cicenaite,et al.  Effect on blood glucose monitoring of skin pressure exerted by an optical coherence tomography probe. , 2008, Journal of biomedical optics.

[2]  Susana de Marcos,et al.  Direct determination of glucose in serum by fluorimetry using a labeled enzyme , 2000 .

[3]  J D Kruse-Jarres,et al.  Multivariate determination of glucose in whole blood by attenuated total reflection infrared spectroscopy. , 1989, Analytical chemistry.

[4]  G. B. Christison,et al.  Laser photoacoustic determination of physiological glucose concentrations in human whole blood , 1993, Medical and Biological Engineering and Computing.

[5]  Risto Myllylä,et al.  Detecting glucose-induced changes in in vitro and in vivo experiments with optical coherence tomography. , 2008, Journal of biomedical optics.

[6]  H. Heise,et al.  Noninvasive Blood Glucose Assay by Near-Infrared Diffuse Reflectance Spectroscopy of the Human Inner Lip , 1993 .

[7]  C. E. Hasty,et al.  Analysis of metabolites in aqueous solutions by using laser Raman spectroscopy. , 1993, Applied optics.

[8]  G. B. Christison,et al.  Glucose determination by a pulsed photoacoustic technique: an experimental study using a gelatin-based tissue phantom. , 1993, Physics in medicine and biology.

[9]  Klaus Danzer,et al.  Application of Near-Infrared Spectroscopy for Non-Invasive Determination of Blood/Tissue Glucose Using Neural Networks , 1995 .

[10]  B. Frieden,et al.  Laser speckle and related phenomena , 1984, IEEE Journal of Quantum Electronics.

[11]  Zeev Zalevsky,et al.  Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern. , 2010, Journal of biomedical optics.

[12]  Sohrab Mansouri,et al.  A Miniature Optical Glucose Sensor Based on Affinity Binding , 1984, Bio/Technology.

[13]  S. G. Laychock.  Glucose metabolism, second messengers and insulin secretion. , 1990, Life sciences.

[14]  I. Gussak,et al.  Naming of the waves in the ECG, with a brief account of their genesis. , 1998, Circulation.

[15]  M Motamedi,et al.  Noninvasive monitoring of glucose concentration with optical coherence tomography. , 2001, Optics letters.

[16]  Zeev Zalevsky,et al.  Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern. , 2009, Optics express.

[17]  Optical Glucose Monitoring Based on Femtosecond Two-Color Pulse Interferometry , 2006 .

[18]  F. Martin,et al.  DIABETES MELLITUS: DIAGNOSIS AND TREATMENT , 1968, The Medical journal of Australia.

[19]  Michael S. Patterson,et al.  Detection of Changes in Blood Glucose Concentrationin vivo with Spatially Resolved Diffuse Reflectance , 1996 .

[20]  R J McNichols,et al.  Optical glucose sensing in biological fluids: an overview. , 2000, Journal of biomedical optics.

[21]  Multiple-Scattering-Free Optical Glucose Monitoring Based on Femtosecond Pulse Interferometry , 2005 .

[22]  P. Drouin,et al.  Study of blood viscosity and erythrocyte parameters in diabetic patients using an artificial pancreas , 1981 .

[23]  C. Toumazou,et al.  Glucose sensors: a review of current and emerging technology , 2009, Diabetic medicine : a journal of the British Diabetic Association.

[24]  G L Coté,et al.  A fluorescence-based glucose biosensor using concanavalin A and dextran encapsulated in a poly(ethylene glycol) hydrogel. , 1999, Analytical chemistry.

[25]  Alan D. Cherrington,et al.  The Endocrine pancreas and regulation of metabolism , 2001 .

[26]  L. Heinemann,et al.  Sensors for glucose monitoring: technical and clinical aspects , 2001, Diabetes/metabolism research and reviews.

[27]  Hurst Jw.  Naming of the Waves in the ECG, With a Brief Account of Their Genesis , 1998 .

[28]  L. Jovanovic,et al.  Noninvasive glucose monitoring: comprehensive clinical results. Cygnus Research Team. , 1999, JAMA.

[29]  Kirill V. Larin,et al.  Quantification of glucose diffusion in arterial tissues by using optical coherence tomography , 2007 .