Pathogenesis of steatorrhea in primary biliary cirrhosis

To investigate the pathophysiology of steatorrhea in primary biliary cirrhosis, the severity of steatorrhea, small bowel histology and function, cholestasis, exocrine pancreatic secretion and liver histology were studied. Twenty‐four primary biliary cirrhotic patients had a quantitative stool fat collection, serum bilirubin and alkaline phosphatase and liver biopsies. From this group, ten had further studies: a small bowel biopsy (n = 7); a D‐xylose test (n = 9); measurement of pancreatiobiliary concentrations and outputs after intravenous cholecystokinin (n = 10); essential amino acid perfusion of the duodenum (n = 9), and eating a test meal (n = 7).

[1]  J D Emerson,et al.  Analyzing data from ordered categories. , 1984, The New England journal of medicine.

[2]  J. Rodés,et al.  Fat Digestion and Exocrine Pancreatic Function in Primary Biliary Cirrhosis , 1984 .

[3]  R. Chapman,et al.  The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis. , 1982, Gastroenterology.

[4]  I. Kagevi,et al.  On the concurrence of primary biliary cirrhosis and intestinal villous atrophy. , 1982, Scandinavian journal of gastroenterology.

[5]  R. Glickman,et al.  Fat malabsorption--advances in our understanding. , 1979, The American journal of medicine.

[6]  D. Owen,et al.  An association between primary biliary cirrhosis and jejunal villous atrophy resembling celiac disease , 1979, Digestive diseases and sciences.

[7]  E. Dimagno,et al.  Reduced intraluminal bile acid concentrations and fat maldigestion in pancreatic insufficiency: Correction by treatment , 1979 .

[8]  A. Ferguson,et al.  PRIMARY BILIARY CIRRHOSIS AND CŒLIAC DISEASE An Association? , 1978, The Lancet.

[9]  E. Dimagno,et al.  Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. , 1977, The New England journal of medicine.

[10]  E. Dimagno,et al.  Prospective evaluation of the pancreatic secretion of immunoreactive carcinoembryonic antigen, enzyme, and bicarbonate in patients suspected of having pancreatic cancer. , 1977, Gastroenterology.

[11]  E. Dimagno,et al.  Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules. , 1977, The New England journal of medicine.

[12]  E. Dimagno,et al.  Effects of Bile Acids, Lecithin, and Monoolein on Amino Acid Absorption from the Human Duodenum 1 , 1977, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[13]  J. Malagelada,et al.  Measurement of gastric functions during digestion of ordinary solid meals in man. , 1976, Gastroenterology.

[14]  E. Dimagno,et al.  Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. , 1973, The New England journal of medicine.

[15]  P. Jatlow,et al.  Nephelometric determination of pancreatic enzymes. II. Lipase. , 1973, Clinica chimica acta; international journal of clinical chemistry.

[16]  E. Dimagno,et al.  Impaired cholecystokinin-pancreozymin secretion, intraluminal dilution, and maldigestion of fat in sprue. , 1972, Gastroenterology.

[17]  C. Williams,et al.  Steatorrhea in patients with liver disease. , 1971, Canadian Medical Association journal.

[18]  A. Hofmann,et al.  Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products. , 1970, Journal of Clinical Investigation.

[19]  S. Sherlock,et al.  Diminished micellar phase lipid in patients with chronic nonalcoholic liver disease and steatorrhea. , 1970, Gastroenterology.

[20]  V. Go,et al.  Disturbances in fat digestion induced by acidic jejunal pH due to gastric hypersecretion in man. , 1970, Gastroenterology.

[21]  W. Summerskill,et al.  Malabsorption syndrome associated with anicteric liver disease. , 1962, Gastroenterology.

[22]  M. Grossman,et al.  Distribution and fate of pancreatic enzymes in small intestine of the rat. , 1962, The American journal of physiology.

[23]  B. Nordin,et al.  Malabsorption and bone disease in prolonged obstructive jaundice. , 1956, The Quarterly journal of medicine.

[24]  J. Gross,et al.  Total solids, fat and nitrogen in the feces: V. A study of patients with primary parenchymatous hepatic disease. , 1950, Gastroenterology.

[25]  A. Sobel,et al.  A CONVENIENT METHOD OF DETERMINING SMALL AMOUNTS OF AMMONIA AND OTHER BASES BY THE USE OF BORIC ACID , 1937 .

[26]  E. Dimagno,et al.  Triolein breath test: a sensitive and specific test for fat malabsorption. , 1979, Gastroenterology.

[27]  E. Dickson,et al.  Primary biliary cirrhosis. , 1979, Progress in liver diseases.

[28]  P. Jatlow,et al.  Nephelometric determination of pancreatic enzymes , 1973 .

[29]  P. Talalay.  Enzymic analysis of steroid hormones. , 1960, Methods of biochemical analysis.

[30]  D. Turner,et al.  Total Fatty acids in Stool , 1958 .

[31]  S. Hyden.  A turbidimetric method for the determination of higher polyethylene glycols in biological materials. , 1956 .